Thiourea and many of its unsymmetrical derivatives have marked physiological action; thiourea causes a slowing of the pulse and respiration, cardiac failure, and death in convulsions; phenyl-, ethyland acetyl-thiourea are actively toxic. The most important derivative pharmacologically is allyl-thiourea, also known as thiosinamine or rhodallin, NH2 CS NH CH2 CH:CH2.
Thiosinamine is given internally in doses of to i gr.
Fibrolysin is a modified form of thiosinamine made by mixing it with sodium salicylate Fibrolysin is freely soluble and may be given in hypodermic or intra-muscular injection.
Like thiosinamine it has a specific action on scar tissue and has been used in urethral strictures.