How to use Scid in a sentence

scid
  • Severe combined immunodeficiency (SCID) is the most serious primary or congenital human immunodeficiency disorder.

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  • Children with SCID are vulnerable to recurrent severe infections, retarded growth, and early death.

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  • In children with SCID, the immune system does not function properly because T, B, and NK cells are either absent or defective.

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  • Several different immune system disorders are grouped under SCID.

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  • Children with X-linked SCID have low T-cell and natural killer (NK) cell levels but elevated B-cell levels.

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  • In this form of SCID the lymphocyte or white blood evaluation is identical to X-linked SCID but is autosomal recessive and, therefore, occurs in girls and boys.

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  • The rate of SCID is not perfectly documented.

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  • In all forms of SCID, B and T cells are non-functioning.

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  • They may or may not be present in various forms of SCID, but they are always non-functioning.

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  • In some forms of SCID, NK cells are also absent or non-funtioning.

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  • For the first few months after birth, an infant with SCID is often protected by antibodies acquired before birth from the mother's blood.

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  • As early as three months of age, however, the SCID child begins to suffer from mouth infections (thrush), chronic diarrhea, otitis media, and pulmonary infections, including pneumocystis pneumonia.

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  • The first screening test for SCID is a white blood cell count with a count of the lymphocytes (differential) because in most forms of SCID the lymphocyte count will be very low.

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  • If the numbers of all of these cell types are normal and SCID is still suspected, more specialized tests can be done to test the lymphocyte cell functions.

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  • Rarely there are children with SCID who have normal lymphocyte numbers and nonfunctioning cells.

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  • Bone marrow transplants are as of 2004 regarded as one of the few effective standard treatments for most types of SCID.

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  • As an example of gene therapy for SCID children with ADA deficiency, the child receives periodic infusions of his or her own T cells corrected with a gene for ADA that has been implanted in an activated virus.

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  • Other types of SCID have been treated with gene therapy, but these procedures have been put on hold due to serious complications (malignancies).

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  • Researchers are as of 2004 also investigating treating SCID in the yet unborn fetus, which has been done successfully a few times.

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  • Genetic counseling is recommended for parents of a child with SCID who are considering having more children and for potential parents who have a family history of the disease and believe they may be carriers.

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  • Without prompt treatment SCID is nearly always fatal.

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  • Research is continuing into in utero treatment options, and some in utero treatments have been successfully carried out, so fetal screening may be helpful if there is a possibility that the child has SCID.

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  • Adenosine deaminase (ADA)-An enzyme that is lacking in a specific type of severe combined immunodeficiency disease (SCID).

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  • For example, severe combined immunodeficiency disease (SCID) is caused by the defective development or function of these two types of lymphocytes.

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  • If the deficiency is not treated (usually by bone marrow transplant), a person with SCID usually dies from infection before the age of two years.

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  • The most common form of SCID is X-linked, i.e. the defect is on the X chromosome and, therefore, occurs only in boys.

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  • In the early 2000s new genetic defects leading to SCID are being identified each year.

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  • For most patients with SCID, bone marrow transplantation is necessary.

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