Quinoline Sentence Examples
This compound condenses in alkaline solution with compounds containing the grouping - CH 2 - CO - to form quinoline or its derivatives; thus, with acetaldehyde it forms quinoline, and with acetone, a-methyl quinoline.
Marckwald (Ann., 93, 74, 331; 1894, 79, 14) has supported this formula from considerations based on the syntheses of the quinoline ring.
Similarly a CH group may be replaced by a nitrogen atom with the production of compounds of similar stability; thus benzene gives pyridine, naphthalene gives quinoline and isoquinoline; anthracene gives acridine and a and 3 anthrapyridines.
Naphthyridines and naphthinolines result from the condensation of two pryridine and two quinoline nuclei respectively; and quino-quinolines are unsymmetrical naphthyridine nuclei condensed with a benzene nucleus.
It combines with alkaline chlorides - potassium, rubidium and caesium - to form crystalline plumbichlorides; it also forms a crystalline compound with quinoline.Advertisement
Instances of its application are found in the separation of orthoand para-nitrophenol, the o-compound distilling and the p- remaining behind; in the separation of aniline from the mixture obtained by reducing nitrobenzene; of the naphthols from the melts produced by fusing the naphthalene monosulphonic acids with potash; and of quinoline from the reaction between aniline, nitrobenzene, glycerin, and sulphuric acid (the product being first steam distilled to remove any aniline, nitrobenzene, or glycerin, then treated with alkali, and again steam distilled when quinoline comes over).
Konigs, expressed the opinion that the alkaloids were derivatives of pyridine or quinoline.
This view has been fairly well supported by later discoveries; but, in addition to pyridine and quinoline nuclei, alkaloids derived from isoquinoline are known.
It occasionally acts as an oxidizing agent, as in the preparation of quinoline and fuchsine.
Distilled with zinc dust morphine yields phenanthrene, pyridine and quinoline; dehydration gives, under certain conditions, apomorphine, C17H17N02, a white amorphous substance, readily soluble in alcohol, either and chloroform.Advertisement
Quinoline is a colourless liquid with a smell resembling that of pyridine.
The reaction is a perfectly general one, for the aniline may be replaced by other aromatic amines and the aldehyde by other aldehydes, and so a large number of quinoline homologues may be prepared in this way.
It may be separated from the quinoline which accompanies it by means of the difference in the solubility of the sulphates of the two compounds, isoquinoline sulphate being much less soluble than quinoline sulphate.
Baeyer by removing the elements of hydriodic acid from iodocyclo-hexane on boiling it with quinoline.
His perception of the analogy between it and ammonia led to his famous work on the amines and ammonium bases and the allied organic phosphorus compounds, while his researches on rosaniline, which he first prepared in 1858, formed the first of a series of investigations on colouring matters which only ended with quinoline red in 1887.Advertisement
Bamberger's observations on reduced quinoline derivatives point to the same conclusion, that condensed nuclei are not benzenoid, but possess an individual character, which breaks down, however, when the molecule is reduced.
Riiber (Ber., 1902, 35, p. 2411; 1904, 37, P. 22 74), by oxidizing diphenyl-2.4-cyclo-butane-bismethylene malonic acid (fron cinnamic aldehyde and malonic acid in the presence of quinoline) with potassium permanganate.