Pyrin Sentence Examples

The MEFV gene carries the instructions for production of a protein called pyrin, named for pyrexia, a medical term for fever.

Research has shown that pyrin has some function in controlling neutrophils, which are the white blood cells that move into an area of the body affected by stress or trauma.

In a person with a normal immune system, some inflammation may follow stress or trauma, but the pyrin protein is responsible for shutting down the response of neutrophils once they are no longer needed.

An abnormal pyrin protein associated with FMF may be partly functional but unstable.

In some instances, the abnormal pyrin itself seems to be "stressed", and loses its ability to regulate the inflammatory response to trauma.

Exactly what causes pyrin in FMF to lose its ability to control neutrophils in some situations is not fully understood as of 2004.

The MEFV gene involved in FMF produces an unstable form of pyrin that fails to adequately control the inflammatory response.