How to use Protoporphyrins in a sentence

protoporphyrins
  • Owing to a defect in one of the enzymes of the heme biosynthesis pathway, protoporphyrins or porphyrins (heme precursors) are prevented from proceeding further along the pathway.

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  • If the porphyria becomes symptomatic, the common factor between all types is an abnormal accumulation of protoporphyrins or porphyrin.

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  • Deposits of protoporphyrins can sometimes lead to red staining of the teeth and bones.

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  • A common initial test measures protoporphyrins in the urine.

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  • If these tests reveal abnormal levels of protoporphyrins, further tests are done to measure heme precursor levels in red blood cells and the stool.

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  • The presence and estimated quantity of porphyrin and protoporphyrins in biological samples are easily detected using spectrofluorometric testing.

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  • The porphyrins and protoporphyrins in the sample absorb the light energy and fluoresce, or glow.

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  • The spectrofluorometer detects and measures fluorescence, which indicates the amount of porphyrins and protoporphyrins in the sample.

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