How to use Protoporphyrins in a sentence
Owing to a defect in one of the enzymes of the heme biosynthesis pathway, protoporphyrins or porphyrins (heme precursors) are prevented from proceeding further along the pathway.
If the porphyria becomes symptomatic, the common factor between all types is an abnormal accumulation of protoporphyrins or porphyrin.
Deposits of protoporphyrins can sometimes lead to red staining of the teeth and bones.
A common initial test measures protoporphyrins in the urine.
If these tests reveal abnormal levels of protoporphyrins, further tests are done to measure heme precursor levels in red blood cells and the stool.Advertisement
The presence and estimated quantity of porphyrin and protoporphyrins in biological samples are easily detected using spectrofluorometric testing.
The porphyrins and protoporphyrins in the sample absorb the light energy and fluoresce, or glow.
The spectrofluorometer detects and measures fluorescence, which indicates the amount of porphyrins and protoporphyrins in the sample.