PIPERINE, C17H,9N03, an alkaloid found in the fruits of Piper nigrum and P. longum.
Piperine consequently is (2).
The synthesis of piperine follows from the interaction of piperyl chloride (formed from piperic acid and phosphorus pentachloride) and piperidine (L.
Piperine, conine, atropine, belladonine, cocaine, hyoscyamine and nicotine have been already synthesized; the constitution of several others requires confirmation, while there remain many important alkaloids - quinine, morphine, strychnine, &c. - whose constitution remains unknown.
(1) Pyridine group. Piperine; conine; trigonelline; arecaidine; guvacine; pilocarpine; cytisine; nicotine; sparteine.
Piperidine or hexa-hydropyridine, C 5 H 11 N, was first obtained in 1848 by distilling piperine with lime.
We also owe much of our knowledge of the alkaloid piperine to Fittig, who in collaboration with Ira Remsen established its constitution in 1871.