In large doses it is a dangerous poison, converting the oxyhaemoglobin of the blood into methaemoglobin.
Like alcohol and prussic acid, quinine interferes with oxidation, so that oxyhaemoglobin is relatively unable to give up its oxygen to the tissues, the metabolism of which is therefore greatly modified.
The action is not due to any influence on the thermic centres, nor to any production of diaphoresis, but to the influence of quinine upon the stability of oxyhaemoglobin.
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