How to use Osteopetrosis in a sentence

osteopetrosis
  • Osteopetrosis (plural osteopetroses) is a rare inherited disorder that makes bones increase in both size (mass) and fragility.

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  • Osteopetrosis is also called chalk bones, ivory bones, or marble bones.

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  • Osteopetrosis occurs when there is a failure in bone resorption.

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  • Other forms of osteopetrosis progress at a more rapid pace and destroy bone structure, which can involve bones throughout the body, although the lower jaw is never affected.

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  • Severe malignant infantile osteopetrosis (early-onset osteopetrosis) is the most severe form of osteopetrosis.

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  • Early-onset osteopetrosis can be a fatal condition, with death occurring before the age of two.

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  • Although this form of osteopetrosis is called "malignant," it is not a type of cancer.

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  • Intermediate osteopetrosis generally appears in children under age ten.

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  • This condition is usually less severe than early-onset or malignant infantile osteopetrosis and is not normally life-threatening.

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  • Adult (delayed-onset) osteopetrosis may not become evident until after age 20.

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  • Many people with adult osteopetrosis are diagnosed only when abnormalities are discovered on x rays taken for other purposes.

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  • There are two distinct types of adult osteopetrosis (types I and II).

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  • The incidence of osteopetroses is not known, although it is estimated that adult osteopetrosis occurs in about one of every 1,250 individuals.

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  • Worldwide malignant infantile osteopetrosis occurs in about one in 100,000 to 500,000 births, making it exceedingly rare.

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  • Osteopetrosis is the result of a genetic defect that causes the body to add new bone more rapidly than existing bone disintegrates.

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  • Osteopetrosis is usually diagnosed when x rays reveal abnormalities or increases in bone density.

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  • Interferon gamma-1b (Actimmune) is the only drug approved by the United States Food and Drug Administration (FDA) to treat osteopetrosis.

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  • Injections delay the progress of severe osteopetrosis in both children and adults.

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  • Bone marrow transplantation (BMT) is the only therapy that can completely cure severe malignant infantile osteopetrosis.

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  • The survival rate for children with osteopetrosis who undergo BMT is 40 to 70 percent.

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  • The severity of anemia seems to determine the course of an individual's osteopetrosis.

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  • About two-thirds of children who have severe malignant infantile osteopetrosis die before age ten unless they have a successful bone marrow transplant.

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  • Osteopetrosis is an inherited disease that cannot be prevented.

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  • The more severe form of congenital osteopetrosis is usually fatal within the first ten years of life unless successfully treated with a bone marrow transplant.

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