This service is to be extended further with an adolescent clinic at UCLH where 4-6 patients including osteogenesis imperfecta will be seen.
Specific diseases causing an increased risk for fractures include Paget's disease, rickets, osteogenesis imperfecta, osteoporosis, bone cancer and tumors, and prolonged disuse of a nonfunctional body part such as after a stroke.
Osteogenesis imperfecta-An inherited disorder of the connective tissues that involves multiple symptoms, including weakened bones that break easily.
Osteogenesis imperfecta (OI) is a group of genetic diseases in which the bones are formed improperly, making them fragile and prone to breaking.
In osteogenesis imperfecta, the collagen produced is abnormal and disorganized, which results in a number of abnormalities throughout the body, the most notable being fragile, easily broken bones.
Unfortunately, because of the unusual nature of the fractures occurring in a baby who is not yet mobile, some parents have been accused of child abuse before the actual diagnosis of osteogenesis imperfecta was reached.
Niyibizi, C., et al. "Potential of gene therapy for treating osteogenesis imperfecta."
"Severe osteogenesis imperfecta: new therapeutic options?"
Osteogenesis Imperfecta Foundation. 804 W.
Children born with co-existing craniofacial conditions, such as Apert syndrome, which affects the growth of the jaw, may benefit from a technique called mandibular bone lengthening or distraction osteogenesis.
However, the process of osteogenesis (development of bone) has not progressed to the point where the bones are "bony."
Osteogenesis imperfecta: Also called brittle bone disease, this condition is characterized by fragile bones that are prone to fracturing.
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