Reducing oxygen also reduces bone formation by specialized cells called osteoblasts.
One of the markers we measure is osteocalcin, a protein produced by osteoblasts.
In healthy individuals, bones are constantly being broken down (resorption) by cells called osteoclasts, and new bone material is constantly being formed by cells called osteoblasts.
In bone remodeling, complex chemical signals prompt cells called osteoclasts to break down and remove (resorb) old bone, and others called osteoblasts to deposit new bone.
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