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orexins

orexins Sentence Examples

  • The nerve cells, or neurons, in this part of the hypothalamus secrete substances known as hypocretins or orexins, which regulate the sleep/wake cycle in humans.

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  • As of the early 2000s, narcolepsy is thought to be an orexin deficiency syndrome; that is, it develops when a person's hypothalamus does not secrete enough orexins to keep the person from falling asleep at inappropriate times.

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  • Samples of cerebrospinal fluid taken from patients with narcolepsy contain little or no orexins.

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  • MRI scans of these patients indicate that there is some loss of brain tissue in the hypothalamus itself, suggesting that the neurons responsible for secreting orexins have died.

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  • Yanagisawa. "Orexins: From Neuropeptides to Energy Homeostasis and Sleep/Wake Regulation."

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