Malonic sentence example
- Dibromcotinine on hydrolysis yields oxalic acid, methylamine and 0-methyl pyridyl ketone: C10H10Br2N20+3H20+0= H2C204-ECH 3 NH 2 +C 5 H 4 N 000H 3 +2HBr; whilst dibromticonine yields methylamine, malonic acid and nicotinic acid: C10H8Br2N202+ 4H20=CH 3 NH 2 +CH 2 (CO 2 H) 2 +C 5 H 4 N CO 2 H+2HBr, or if heated with zinc and caustic potash, methylamine and pyridyl-ay-dioxybutyric acid.
- Malonic acid, as well as its esters, is characterized by the large number of condensation products it can form.
- Many esters of malonic acid have been prepared, the most important being the diethyl ester (malonic ester), CH 2 (000C 2 H 5) 2, which is obtained by dissolving monochloracetic acid in water, neutralizing the solution with potassium carbonate, and then adding potassium cyanide and warming the mixture until the reaction begins.
- It is a most important synthetic reagent; with sodium or sodium ethylate it forms sodio-malonic ester, which reacts readily with alkyl halides, forming alkyl malonic esters, which are again capable of forming sodium derivatives, that by further treatment with alkyl halides yield the di-alkyl malonic esters.
- The half nitrile of malonic acid is cyanacetic acid, CN CH 2 COOH, which, in the form of its ester, may be obtained by the action of a solution of potassium cyanide on monochloracetic acid.Advertisement
- The true nitrile of malonic acid is methylene cyanide, CH 2 (CN) 2, which is obtained by distilling a mixture of cyanacetamide and phosphorus pentoxide.
- Potassium bichromate oxidizes it to malonic acid; nitric acid oxidizes it to oxalic acid; and hydriodic acid reduces it to succinic acid.
- Dibasic acids of the paraffin series of hydrocarbons have the general formula C n H 2 (000H) 2 "; malonic and succinic acids are important members.
- Of foremost importance are the reactions termed the malonic acid and the aceto-acetic ester syntheses; these are discussed under their own headings.
- It liquefies at 7° C. It is an exceedingly reactive compound, combining with water to form malonic acid, with hydrogen chloride to form malonyl chloride, and with ammonia to form malonamide.Advertisement
- It can be prepared by the reduction of phenyl propiolic acid with zinc and acetic acid, by heating benzal malonic acid, by the condensation of ethyl acetate with benzaldehyde in the presence of sodium ethylate or by the so-called "Perkin reaction"; the latter being the method commonly employed.
- Riiber (Ber., 1902, 35, p. 2411; 1904, 37, P. 22 74), by oxidizing diphenyl-2.4-cyclo-butane-bismethylene malonic acid (fron cinnamic aldehyde and malonic acid in the presence of quinoline) with potassium permanganate.
- The 1.4 compound also boils at 81-82° C. and on oxidation gives succinic and malonic acids.
- The oxyderivatives of the tetrahydroand hexahydro-pyrimidines are the uracils and the ureides of malonic acid (see PuRIN).
- From the nitroacetic acid obtained above, malonic acid was prepared, and from this a monochlormalonic acid was obtained; we assume the chlorine atom to replace the c hydrogen atom.Advertisement
- Herrmann, Ann., 1882, 211, p. 306; also see below, Configuration of the Benzene Complex); the condensation of acetone dicarboxylic ester with malonic ester to form triketohexamethylene dicarboxylic ester (E.
- It liquefies at 7Ã‚° C. It is an exceedingly reactive compound, combining with water to form malonic acid, with hydrogen chloride to form malonyl chloride, and with ammonia to form malonamide.
- The 1.4 compound also boils at 81-82Ã‚° C. and on oxidation gives succinic and malonic acids.