Some children may also have frequent digestive disturbances and diarrhea that can lead to improper absorption of nutrients and malnourishment, occurring most commonly in IgA deficiency.
A characteristic finding in children diagnosed with HSP is higher levels of immunoglobulin A (IgA) in the blood and deposits of IgA on the walls of the child's blood vessels.
Patients with other conditions in which celiac disease may be more commonly found include those with juvenile chronic arthritis, some thyroid diseases, and IgA deficiency.
Immunoglobulin deficiencies refer to missing or reduced levels of immunoglobulin (IgG, IgA, IgM) associated with an inability to make adequate specific antibody.
In these disorders, specific diseasefighting antibodies (immunoglobulins such as IgG, IgA, and IgM) are either missing or are present in reduced levels.
Researchers have found that giving artificial CD40 ligand to specially bred immunodeficient mice improves their ability to make IgA and IgG antibodies.
This condition results in the loss of several antibody classes and subclasses, including most IgG antibodies and all IgA and IgE antibodies.
A child with hyper-IgM syndrome will be found to have abnormally low levels of IgA and IgG antibodies and a normal or elevated level of IgM.
As a result, boys with XHIM have abnormally low levels of IgG and IgA in their blood, with normal or higher than normal levels of IgM.
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