Hemophilia Sentence Examples
About 20 percent of all individuals with hemophilia A begin to produce antibodies in their blood against the specific factor protein; the presence of antibodies may then rapidly destroy infused factor VIII.
Hemophilia A is diagnosed with laboratory tests that can detect the presence of clotting factor VIII, factor IX, and others, as well as the presence or absence of clotting factor inhibitors.
Gene carriers for both forms of hemophilia can be detected through DNA studies in conjunction with results from factor VIII assays.
Comprehensive care addresses children's needs by providing various types of counseling to help deal with the psychosocial aspects of diseases such as von Willebrand's and hemophilia.
With mild bleeding episodes in persons afflicted with hemophilia A, infusions of a drug called desmopressin (DDAVP) may be administered.Advertisement
Christmas disease is treated similarly to hemophilia A, with a mix of synthetic products and human blood products to provide coagulation factors as needed.
Factor XI (hemophilia C) deficiency is most often treated with plasma, since there are no commercially available concentrates of factor XI in the United States.
People who have hemophilia A or B and other bleeding disorders are advised to avoid activities and contact sports that can cause severe injury.
Berntorp, Erik, et al. Textbook on Hemophilia.
By 1997, approximately 800 different diagnostic tests were available, most of them for hereditary genetic disorders such as Tay-Sachs disease, sickle cell anemia, hemophilia, muscular dystrophy, and cystic fibrosis.Advertisement
Examples of genetic conditions include Down syndrome, Tay-Sach's disease, sickle cell disease, and hemophilia.
Hemophilia is a coagulation disorder arising from a genetic defect of the X chromosome; the defect can either be inherited or result from spontaneous gene mutation.
In each type of hemophilia (hemophilias A, B, and C), a critical coagulation protein is missing, causing individuals to bleed for long periods of time before clotting occurs.
In hemophilia, certain clotting factors are either decreased in quantity, absent altogether, or improperly formed, preventing the formation of a clot and resulting in uncontrolled bleeding.
Hemophilia A is the most common type of coagulation disorder and involves decreased activity of factor VIII.Advertisement
Individuals with less than 1 percent of normal factor VIII activity level have severe hemophilia.
Individuals with 1-5 percent of normal factor VIII activity level have moderate hemophilia and are at risk for heavy bleeding after seemingly minor traumatic injuries.
Individuals with 5-40 percent of normal factor VIII activity level have mild hemophilia and must prepare carefully for any surgery or dental procedures.
Hemophilia A affects between one in 5,000 to one in 10,000 males in most populations.
Hemophilia B occurs in one in 40,000 to 50,000.Advertisement
The prevalence of hemophilia is estimated to be 13.4 cases per 100,000 U.S. males (10.5 hemophilia A and 2.9 hemophilia B).
Hemophilia C occurs primarily among individuals of Jewish descent.
Hemophilia A and B are both caused by a genetic defect present on the X chromosome.
About 70 percent of all people with hemophilia A or B inherited the disease.
Both factors VIII and IX are produced by a genetic defect of the X chromosome, so hemophilia A and B are both sex-linked diseases passed on from a female to male offspring.Advertisement
Therefore, even if she receives one flawed X chromosome, she will still be capable of producing a sufficient quantity of factors VIII and IX to avoid the symptoms of hemophilia.
Hemophilia is an inherited bleeding disorder characterized by prolonged or spontaneous bleeding, especially into the muscles, joints, or internal organs.
There are also a number of related bleeding disorders where there are other factor deficiencies that are much rarer than hemophilia.
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She carries the flaw that causes hemophilia and can pass it on to her offspring.
If, however, she has a son who receives her flawed X chromosome, he will be unable to produce the right quantity of factors VIII or IX, and he will suffer some degree of hemophilia.
However, the vast majority of people with either hemophilia A or B are male.
About 30 percent of all people with hemophilia A or B are the first member of their family to ever have the disease.
In the case of severe hemophilia, the first bleeding event usually occurs prior to 18 months of age.
In some babies, hemophilia is suspected immediately when a routine circumcision (removal of the foreskin of the penis) results in unusually heavy bleeding.
Hemophilia B symptoms are similar to those of hemophilia A, including numerous large and deep bruises and prolonged bleeding.
People with hemophilia are at very high risk of severe, heavy, uncontrollable bleeding (hemorrhage) from injuries such as motor vehicle accidents and also from surgery.
Some other rare clotting disorders such as von Willebrand's disease present similar symptoms but are not usually called hemophilia.
Hemophilia is usually discovered when an injury initiates bleeding and the bleeding will not stop.
In very young children, spontaneous musculoskeletal bleeding may occur around the time the child begins to walk; these episodes may be the first sign of hemophilia.
This information helps to confirm a diagnosis of hemophilia and identifies the type and severity of hemophilia present.
Families with a history of hemophilia can also have tests done during a pregnancy to determine whether the fetus will have hemophilia.
Chorionic villous sampling is a test that examines proteins for deficiencies or defects that are characteristic of hemophilia.
The treatment of hemophilia involves replacing or supplementing the deficient coagulation factors.
Appropriate treatment of hemophilia can decrease suffering and be lifesaving in the presence of hemorrhage.
Molecular biological techniques have introduced gene therapies as new treatment possibilities for hemophilia.
Variations in the type and severity of hemophilia makes it difficult to generalize a prognosis, however, for individuals with mild hemophilia, the prognosis is quite good.
Those with more severe hemophilia can also live relatively normal lives with careful management and avoidance of injury.
Because of its genetic origins, hemophilia cannot be prevented in those born with the inherited defects or factor deficiencies.
However, individuals who have a family history of hemophilia may benefit from genetic testing and counseling before deciding to have a baby.
The most important way for individuals with hemophilia to prevent complications of the disease is to avoid activities that may lead to injury.
When a child has an inherited coagulation disorder such as hemophilia, parents will be concerned about the possibility of trauma or injury that may lead to potentially dangerous bleeding episodes.
The watchfulness of parents along with effective management of hemophilia by physicians can help the child to lead a relatively normal life.
Counseling is available to help children handle the psychosocial aspects of living with hemophilia.
Children seem to stay in balance unless a bleeding disorder of some kind exists, either hereditary (hemophilia or von Willebrand's) or related to hookworm infection or another illness.
These include the coagulation disorders hemophilia A and hemophilia B, and von Willebrand's disease, a bleeding disorder caused by a deficiency in von Willebrand factor, an essential component of the coagulation system.
Certain blood disorders, such as hemophilia, can cause the nose to bleed.
Unlike hemophilia, where bleeding is caused by an ineffective clotting mechanism in the blood, bleeding in hereditary hemorrhagic telangiectasia is caused by fragile blood vessels.
However, like hemophilia, bleeding may be extensive and can occur without warning.
The most commonly known coagulation disorder is hemophilia, a condition in which a critical component of blood coagulation is missing, causing individuals to bleed for long periods of time before clotting occurs.
Hemophilia or hemophilia A (factor VIII deficiency) is an inherited coagulation disorder, affecting about 20,000 Americans.
Christmas disease or hemophilia B (factor IX deficiency) is less common than hemophilia A with similar symptoms.
Other coagulation disorders include factor XI deficiency (hemophilia C), and factor VII deficiency.
Hemophilia C afflicts one in 100,000 people and is the second most common bleeding disorder among women.
Because of its hereditary nature, hemophilia A may be suspected before symptoms occur.
Some signs of hemophilia A are numerous large, deep bruises and painful, swollen joints caused by internal bleeding.
Individuals with hemophilia do not bleed faster, just longer.
A person with mild hemophilia may first discover the disorder with prolonged bleeding following a surgical procedure or injury.
Mild and severe hemophilia A are inherited through a complex genetic system that passes a recessive gene on the female chromosome.
Women usually do not show signs of hemophilia but are carriers of the disease.
Each male child of the carrier has a 50 percent chance of having hemophilia, and each female child has a 50 percent chance of passing the gene on.
Hemophilia B symptoms are similar to those of hemophilia A, including numerous, large, and deep bruises and prolonged bleeding.
Hemophilia most often occurs in families with a known history of the disease, but occasionally, new cases occur in families with no apparent history.
Factor XI deficiency, or hemophilia C, is a bleeding disorder that occurs among certain ethnic groups.
What differentiated this bleeding disorder from classical hemophilia was that it appeared not to be associated with muscle and joint bleeding and affected women and men rather than just men.