Globin sentence example

globin
  • This circumstance substantially reduces the amount of alpha globin that the body produces.
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  • By a dilute acid haemoglobin is decomposed into globin, and " haematin," a ferri-pyrrol derivative of the probable formula C34H34N4FeOs; under certain conditions the iron-free " haematoporphyrin " is obtained.
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  • They found that zeta globin was able to replace the faulty beta globin, in the same way that gamma globin can.
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  • Thalassemias are classified according to the globin that is deficient.
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  • Individuals inherit from each parent a gene controlling alpha globin production.
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  • Two spots (called loci) on these genes control alpha globin production.
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  • It is caused by a change in the gene for the beta globin component of hemoglobin.
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  • These changes cause little or no globin to be produced.
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  • There are rare exceptions, notably with beta thalassemia, where globin gene mutations exhibit a dominant pattern of inheritance in which only one gene needs to be altered in order to see disease expression.
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  • Most individuals have four normal copies of the alpha globin gene, two copies on each chromosome 16.
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  • Alpha globin is also a component of fetal hemoglobin.
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  • Absence of one functioning alpha globin gene leads to a condition known as silent alpha thalassemia trait.
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  • Alpha thalassemia trait occurs when two alpha globin genes are missing or not functioning.
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  • This syndrome can be caused by a deletion of a significant amount of chromosome 16, affecting the alpha globin genes.
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  • Alpha thalassemia major results from the deletion of all four alpha globin genes, such that there are no functioning alpha globin genes.
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  • Most individuals have two normal copies of the beta globin gene, which is located on chromosome 11 and makes the beta globin component of normal adult hemoglobin.
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  • No beta globin is produced with a beta0 mutation, and only a small fraction of the normal amount of beta globin is produced with a beta+ mutation.
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  • When an individual has one normal beta globin gene and one with a beta thalassemia mutation, he or she is said to carry the beta thalassemia trait.
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  • Because alpha globin is a necessary component of hemoglobin, absence of all functioning alpha globin genes leads to serious medical consequences that begin even before birth.
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  • Hemoglobin consists primarily of iron-bearing proteins called heme groups and moiety globin protein, which together give hemoglobin its ability to carry oxygen.
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  • The genetic defects are subdivided into errors of heme production (porphyria) and those of globin production, known collectively as the hemoglobinopathies.
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  • This occurs in many diseases, including iron deficiency anemia, thalassemia (an inherited disease in which globin chain production is deficient), and anemias associated with chronic infection or disease.
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  • A normal hemoglobin molecule contains two alpha globin molecule contains two alpha globins and two beta globins to make up the complement of 4 globins.
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  • Human adult hemoglobin is actually a composite of four protein chains called globin is actually a composite of four protein chains called globins, knotted around each other.
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  • Since there are four genes (instead of the usual two) to consider when looking at alpha globin gene inheritance, there are several alpha globin types that are possible.
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