The American Academy of Child and Adolescent Psychiatry (AACAP) does not recommend TCAs as a first-line treatment for youths requiring medicine for depressive disorders.
Medications usually are not prescribed for children as a first-line treatment for hypertension.
First-line treatment of high cholesterol for all ages includes diet, exercise, and weight loss.
If first-line treatments fail, isotretinoin (brand name Accutane) is an option.
The quality of the army, thus composed of picked men (a point which is often forgotten), approximated to that of a professional force; but this policy had the result that, as there was no adequate second-line army, parts of the first-line had to be reserved, instead of being employed at the front.