Diagnosis usually requires a number of laboratory tests that measure concentrations of platelets and fibrinogen in the blood along with measuring prothrombin time.
Other supportive data include measuring levels of factors V and VIII, fibrinogen, hemoglobin, and platelets, any of which may be diminished or entirely depleted.
Fibrinogen occurs in the blood plasma, and is changed by a ferment into fibrin, to which the clotting of blood is due.
None of them, in man, coagulates spontaneously, although they contain fibrinogen.
Fibrinogen is insoluble in water, but soluble in salt solutions; it has three different coagulation temperatures, 56°, 6 7°, 75°.
Fibrin, produced from fibrinogen by a ferment, is a jelly-like substance, coagulable by heat, alcohol, &c. The muscle-albumins include " myosin " or paramyosinogen, a globulin, which by coagulation induces rigor mortis, and the closely related " myosinogen " or myogen; myoglobulin and myoalbumin are also found in muscles.