Various diagnostic tests are available to measure, under carefully controlled conditions, the length of time it takes to produce certain components of the final fibrin clot.
Prothrombin, under the right conditions, is converted to thrombin, which activates fibrin and begins the process of coagulation.
Fibrinogen occurs in the blood plasma, and is changed by a ferment into fibrin, to which the clotting of blood is due.
As the edges of the wound are brought into accurate apposition there is little or no blood lodged between them, so that an extremely narrow strip of fibrin glues the cut edges together.
Lying between the fibrin mass and the healthy tissues is a zone of injured and degenerated tissue elements, the result of the trauma.
Numerous fibroblasts, together with polyblasts, are visible in the fibrin mass, and the vessels at the periphery of the damaged zone are now seen to be sending out offshoots which assist in the process of absorption.
The addition of some of the liquid squeezed out from a blood-clot, of the squeezed blood-clot itself, or of a little blood-serum, is sufficient to throw down a fibrinous coagulum (Buchanan), evidently by these substances supplying the fibrin-ferment.
Fibrin, produced from fibrinogen by a ferment, is a jelly-like substance, coagulable by heat, alcohol, &c. The muscle-albumins include " myosin " or paramyosinogen, a globulin, which by coagulation induces rigor mortis, and the closely related " myosinogen " or myogen; myoglobulin and myoalbumin are also found in muscles.
It is believed also that they secrete bactericidal substances and ferments which bring about the liquefaction of the fibrin and the damaged tissues - histolysis - and thus assist the process of absorption.
In 1843, with a thesis on albumin and fibrin, he studied for a year under J.