Fetal hemoglobin sentence example

fetal hemoglobin
  • Drug research is focused on identifying drugs, such as hydroxyurea, that can increase the level of fetal hemoglobin in the blood.
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  • It has been observed that some children with sickle cell anemia continue to produce large amounts of fetal hemoglobin after birth, and studies have shown that these children have less severe cases of the disease.
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  • Fetal hemoglobin seems to prevent "sickling" of red cells, and cells containing fetal hemoglobin tend to survive longer in the bloodstream.
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  • Butyrate, a substance widely used as a food additive, was also being investigated as of 2004 as an agent that may increase fetal hemoglobin production.
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  • H. "Therapies to increase fetal hemoglobin in sickle cell disease."
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  • In thalassemia minor, fetal hemoglobin (HbF), the hemoglobin form that circulates in the fetus, does not decrease normally after birth and may remain high in later life.
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  • Alpha globin is also a component of fetal hemoglobin.
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  • Hydroxyurea-A drug that has been shown to induce production of fetal hemoglobin.
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  • Higher-than-normal levels of fetal hemoglobin can ameliorate some of the symptoms of thalassemia.
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  • A fetal hemoglobin test (Hgb electrophoresis) measures the level of fetal hemoglobin (Hemoglobin F or HbF) in the blood of infants and children.
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  • The determination of fetal hemoglobin in the blood of infants and children identifies normal and abnormal levels, defining what percentage of total hemoglobin is made up of fetal hemoglobin.
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  • Knowing this level may help doctors evaluate low concentrations of normal hemoglobin in red blood cells (anemia), as well as higher-than-normal levels of fetal hemoglobin or its hereditary persistence.
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  • Among the six types of hemoglobin, HbA is the normal adult hemoglobin, and HbF is the major fetal hemoglobin.
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  • During fetal development, fetal hemoglobin composes about 90 percent of total hemoglobin.
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  • At birth, the newborn's blood is composed of about 70 percent fetal hemoglobin.
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  • As the infant's bone marrow begins to produce new red cells, fetal hemoglobin begins to decrease rapidly.
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  • Normally, only 2 percent or less of total hemoglobin is found as fetal hemoglobin after six months and throughout childhood; in adulthood, only traces (0.5% or less) are found in total hemoglobin.
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  • In some diseases associated with abnormal hemoglobin production (hemoglobinopathy), fetal hemoglobin may persist in larger amounts.
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  • When this occurs, the increased amounts of fetal hemoglobin raise questions of possible underlying dysfunction or disease.
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  • Testing for levels of fetal hemoglobin and other types of hemoglobin may be a first, important step in the investigation of possible hemoglobinopathies.
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  • Testing for fetal hemoglobin requires that a blood sample be drawn from the child.
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  • No preparation is needed before performing fetal hemoglobin tests, and fasting (nothing to eat or drink for a period of hours before the test) is not required.
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  • The rapid destruction of red blood cells and subsequent release of fetal hemoglobin into the bloodstream results in the production of bilirubin.
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  • This situation results in jaundice in over 60 percent of newborns, usually due to the presence of fetal hemoglobin released into the blood during the normal destruction of fetal red blood cells.
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