Factor viii sentence example

factor viii
  • Von Willebrand's disease is caused by a defect in the von Willebrand clotting factor, often accompanied by a deficiency of factor VIII as well.
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  • Gene carriers for both forms of hemophilia can be detected through DNA studies in conjunction with results from factor VIII assays.
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  • Hemophilia A is the most common type of coagulation disorder and involves decreased activity of factor VIII.
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  • There are three levels of factor VIII deficiency: severe, moderate, and mild.
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  • Individuals with less than 1 percent of normal factor VIII activity level have severe hemophilia.
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  • Individuals with 1-5 percent of normal factor VIII activity level have moderate hemophilia and are at risk for heavy bleeding after seemingly minor traumatic injuries.
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  • Individuals with 5-40 percent of normal factor VIII activity level have mild hemophilia and must prepare carefully for any surgery or dental procedures.
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  • About 20 percent of all individuals with hemophilia A begin to produce antibodies in their blood against the specific factor protein; the presence of antibodies may then rapidly destroy infused factor VIII.
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  • Those individuals who require dental work or any type of surgery may need to be pre-treated with an infusion of factor VIII to avoid hemorrhage.
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  • A deficiency or abnormality in vWF can interfere with the formation of the temporary platelet plug and affect the normal survival of factor VIII.
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  • They also have a decreased amount of vWF and decreased vWF activity and usually have slightly decreased factor VIII levels and activity.
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  • Children with type 2 VWD have a prolonged bleeding time and decreased activity of vWF; they may also have decreased amounts of vWF and factor VIII and decreased factor VIII activity.
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  • Type 3 children have undetectable amounts of vWF, negligible vWF activity, factor VIII levels of less than 5 to 10 percent, and significantly reduced factor VIII activity.
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  • Patients who are unable to tolerate or are unresponsive to drug-based treatments are treated with concentrated factor VIII obtained from blood products.
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  • Not all factor VIII concentrates can be used, since some do not contain enough vWF.
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  • If the factor VIII concentrates are unable to manage a severe bleeding episode, then blood products called cryoprecipitates, which contain concentrated amounts of vWF, or platelet concentrates should be considered.
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