How to use Factor viii in a sentence
Von Willebrand's disease is caused by a defect in the von Willebrand clotting factor, often accompanied by a deficiency of factor VIII as well.
Gene carriers for both forms of hemophilia can be detected through DNA studies in conjunction with results from factor VIII assays.
Hemophilia A is the most common type of coagulation disorder and involves decreased activity of factor VIII.
Individuals with less than 1 percent of normal factor VIII activity level have severe hemophilia.
Individuals with 1-5 percent of normal factor VIII activity level have moderate hemophilia and are at risk for heavy bleeding after seemingly minor traumatic injuries.Advertisement
Individuals with 5-40 percent of normal factor VIII activity level have mild hemophilia and must prepare carefully for any surgery or dental procedures.
About 20 percent of all individuals with hemophilia A begin to produce antibodies in their blood against the specific factor protein; the presence of antibodies may then rapidly destroy infused factor VIII.
Those individuals who require dental work or any type of surgery may need to be pre-treated with an infusion of factor VIII to avoid hemorrhage.
A deficiency or abnormality in vWF can interfere with the formation of the temporary platelet plug and affect the normal survival of factor VIII.
They also have a decreased amount of vWF and decreased vWF activity and usually have slightly decreased factor VIII levels and activity.Advertisement
Children with type 2 VWD have a prolonged bleeding time and decreased activity of vWF; they may also have decreased amounts of vWF and factor VIII and decreased factor VIII activity.
Type 3 children have undetectable amounts of vWF, negligible vWF activity, factor VIII levels of less than 5 to 10 percent, and significantly reduced factor VIII activity.
Patients who are unable to tolerate or are unresponsive to drug-based treatments are treated with concentrated factor VIII obtained from blood products.
Not all factor VIII concentrates can be used, since some do not contain enough vWF.
If the factor VIII concentrates are unable to manage a severe bleeding episode, then blood products called cryoprecipitates, which contain concentrated amounts of vWF, or platelet concentrates should be considered.Advertisement