Disease Sentence Examples

Now the disease is eradicated.

Given all this, do you really believe this disease still has a chance?

Whatever her disease, it had eluded the doctors for months.

A world without hunger, disease, ignorance, poverty, and war is not a perfect world.

Until you can prove you've got some damn disease, you're on leave without pay.

The most recent statistics show the disease to be diminishing.

Disease is a problem of technology; thus, its solution will be technological.

New, disease resistant trees are bringing back the splendor of what has been called one of the prettiest towns in New England.

The expedition, which originally numbered 2500 men, was reduced by deaths at the hands of the Indians, by disease and privation, within a year to less than Soo men.

A future without disease as we understand the term's meaning today.

Cancer of the Stomach is a common disease.

What evil and error are there in it, if people were dying of disease without help while material assistance could so easily be rendered, and I supplied them with a doctor, a hospital, and an asylum for the aged?

The yellowing and subsequent casting of leaves, for instance, is a very general symptom of disease in plants, and may be induced by drought, extremes of temperature, insufficient or excessive illumination, excess of water at the roots, the action of parasitic Fungi, insects, worms, &c., or of poisonous gases, and so forth; and extreme caution is necessary in.

I'm sure she caught that dreadful disease from one of them and it killed her.

Even though, in his all too brief pontificate, he failed to attain any definite results, he at least fulfilled the first condition of any cure by laying bare the seat of disease, gave an important impetus to the cause of the reform of the Church, and laid down the principles on which this was afterwards carried through.

I am also a historian with a full understanding of how poverty, disease, ignorance, famine, and war have dominated life on this planet.

All health and success does me good, however far off and withdrawn it may appear; all disease and failure helps to make me sad and does me evil, however much sympathy it may have with me or I with it.

There and in Lombardy the disease known as pellagra is most widely diffused.

It must not be overlooked that the living cells of the plant react upon the parasite as well as to all external agencies, and the nature of disease becomes intelligible only if we bear in mind that it consists in such altered metabolismdeflected physiologyas is here implied.

The seriousness of the damage done is illustrated by the ravages of the larch disease, apple canker, &c.

This disease is more accidental than contagious and rarely takes very dangerous proportions.

The object of the hybridizer is to obtain varieties exhibiting improvements in hardihood, vigour, size, shape, colour, fruitfulness, resistance to disease or other attributes.

Claire gave a hint of a nod, remaining under the archway to the parlor, as if entering might subject her to some vile disease from these common folk.

The terrible losses sustained by whole communities of farmers, planters, foresters, &c., from plant diseases have naturally stimulated the search for remedies, but even now the search is too often conducted in the spirit of the believer in quack medicines, although the agricultural world is awakening to the fact that before any measures likely to be successful can be attempted, the whole chain of causation of the disease must be investigated.

We may often distinguish between primary symptoms and secondary or subordinate symptoms, but for the purposes of classification in an article of this scope we shall only attempt to group the various cases under the more obvious signs of disease exhibited.

Spotted Leaves, &c.Discoloured spots or patches on leaves and other herbaceous parts are common symptoms of disease, and often furnish clues to identification of causes, though it must be remembered that no sharp line divides this class of symptoms from the preceding.

Dilophia, Rhytisma, &c. Moreover, variegations deceptively like these disease spots are known, e.g.

The French Academy charged de Quatrefages, Decaisne and Peligot with the study of the disease, and they issued two elaborate reports - Etudes sur les maladies actuelles des vers soie (18J9) and Nouvelles Recherches sur les maladies actuelles des vers a soie (1860); but the suggestions they were able to offer had not the effect of stopping the march of the disease.

In this connexion he established the very important practical conclusion that worms which contract the disease during their own life-cycle retain sufficient vitality to feed, develop and spin their cocoon, although the next generation is invariably infected and shows the disease in its most virulent and fatal form.

The disease is characterized by the decomposition of the blood; in fact it is really a form of dropsy.

If the attack comes on a short time before maturity, the worms are able to spin a cocoon of a feeble character, but worms with this disease never change into chrysalides, but always die in the cocoon before transformation can take place.

Another cause of serious loss to the rearers is occasioned by Flacherie, a disease well known from the earliest times.

Pasteur showed that the origin of the disease proceeded from microscopic organisms called ferments and vitrios.

Flacherie is an intestinal disease of the cholera species and therefore contagious.

The export became important just at the time when disease in Europe had lessened the production on the continent.

In medicine, the term is applied to a school of physicians who, in the time of Celsus and Galen, advocated accurate observation of the phenomena of health and disease in the belief that only by the collection of a vast mass of instances would a true science of medicine be attained.

The drug has been highly and widely recommended in general paralysis, but there remains grave doubt as to its utility in this disease.

The people kiss the cross and bow down to it; and ever after Christ's spirit is enshrined in it; it cures disease, drives off demons, and wards off wind and hail.

On the 19th of April 1791 he died, worn out with suffering and disease.

The disease was inherent in the body politic. Each pope, confronted by the spectre of Ne p otism.

In pneumonia and other acute disease, where the patient is liable to sudden collapse, a hypodermic injection of strychnine will often save the patient's life.

For physiognomy of disease, besides the usual medical handbooks, see Cabuchet, Essai sur l'expression de la face dans les maladies (Paris, 1801); Mantegazza, Physiology of Pain (1893), and Polli, Saggio di fisiognomonia e potognomonia (1837).

The ill-success of the old king in this war aggravated the disease from which he was suffering; and his heart was broken by the discovery that John, for whose sake he had alienated Richard, was in secret league with the victorious allies.

Even to-day the ignorant peasantry of many European countries, Russia, Galicia and elsewhere, believe that all disease is the work of demons, and that medicinal herbs owe their curative properties to their being the materialized forms of benevolent spirits.

It was a land of perpetual sunshine and great fertility; its inhabitants were free from disease and war.

Disease was generally attributed to the anger of the gods.

The factors that enable us to solve for and eliminate disease are getting better all the time, like wind at our back, pushing us forward.

Louis Pasteur came along around this same time and proffered the germ theory of disease and a vaccine for rabies.

Four of the problems I address in this book—ignorance, disease, famine, and poverty—are purely technical problems.

But a world without want and without disease, a world with opportunity for all, is a world where getting along—even when we don't see eye to eye—is going to be a good bit easier.

Doctors came to see her singly and in consultation, talked much in French, German, and Latin, blamed one another, and prescribed a great variety of medicines for all the diseases known to them, but the simple idea never occurred to any of them that they could not know the disease Natasha was suffering from, as no disease suffered by a live man can be known, for every living person has his own peculiarities and always has his own peculiar, personal, novel, complicated disease, unknown to medicine--not a disease of the lungs, liver, skin, heart, nerves, and so on mentioned in medical books, but a disease consisting of one of the innumerable combinations of the maladies of those organs.

Occasional outbreaks of cholera occur from time to time, and in the independent states these cause terrible loss of life, as the natives fly from the disease and spread the infection in every direction.

The decrease of the disease is a direct result of the efforts made to combat it, in the form of special hospitals or pellagrosarf, economic kitchens, rural bakeries and maize-drying establishments.

In a large number of cases, however, the disease is purely local, and does not itself extend far into the organ or tissue affected.

The disease was first noticed in England in 1845; in 1848 it appeared at Versailles; by 1851 it had spread through all the wine-producing countries of Europe, being specially virulent in the lands bordering on the Mediterranean; and in the following year it made its appearance in Madeira.

Heraclius died of his disease in 642.

In its tertiary stages - and also earlier - this disease yields in the most rapid and unmistakable fashion to iodides; so much so that the administration of these salts is at present the best means of determining whether, for instance, a cranial tumour be syphilitic or not.

And cause all who communicate to receive a drug of life for healing of every disease and empowering of all moral advance and virtue."

The Indians have a habit of consuming a yellowish edible earth containing sulphur; on pilgrimages they obtain images moulded of this earth at the shrines they visit, and eat the images as a prophylactic against disease.

Prince Charles Gunther succeeded on the 17th of July 1880, his father having on account of eye disease renounced the throne in favour of his son.

The superintendent of the Ninth Census, 1870, presented a computation 01 the effects of this causefirst, through direct losses, by wounds or disease, either in actual service of the army or navy, or in a brief term following discharge; secondly, through the retardation of the rate of increase in the colored element, due to the privations, exposures and excesses attendant upon emancipation; thirdly, through the check given to immigration by the existence of war, the fear of conscription, and the apprehension abroad of results prejudicial to the national welfare.

Canada is entirely free from rinderpest, pleuropneumonia and foot-and-mouth disease.

His successor, Sir John Thompson, after a successful leadership of about two years, died suddenly of heart disease at Windsor Castle, immediately after being sworn of the imperial privy council.

In the thirteenth, after the death of Alexander (June 323) in the archonship of Cephisodorus (323-322), having departed to Chalcis, he died of disease (322), after a life of three-and-sixty years.

But he was then a busy teacher, was growing old, and suffered from a disease in the stomach for a considerable time before it proved fatal at the age of sixty-three.

Pettenkofer gave vigorous expression to his views on hygiene and disease in numerous books and papers; he was an editor of the Zeitschrift far Biologie from 1865 to 1882, and of the Archiv far Hygiene from 1883 to 1894.

Another disease which is sometimes confused with that caused by the Peziza is " heart-rot "; it occasionally attacks larches only ten years old or less, but is more common when the trees have acquired a considerable size, sometimes spreading in a short time through a whole plantation.

The trees for a considerable period show little sign of unhealthiness, but eventually the stem begins to swell somewhat near the root, and the whole tree gradually goes off as the disease advances; when cut down, the trunk is found to be decayed at the centre, the " rot " usually commencing near the ground.

In Lower Egypt practically all the mummies have perished; but in Upper Egypt, as they were put out of reach of the inundation, the cemeteries, in spite of rifling and burning, yield immense numbers of preserved bodies and skeletons; attention has from time to time been directed to the scientific examination of these in order to ascertain race, cause of death, traces of accident or disease, and the surgical or medical processes which they had undergone during life, &c. This department of research has been greatly developed by Dr Elliott Smith in Cairo.

Amontons, who through disease was rendered almost completely deaf in early youth, died at Paris on the II th of October 1705.

This disease, which at a later period became known as " pebrine " - a name given to it by de Quatrefages, one of its many investigators - had first been noticed in France at Cavaillon in the valley of the Durance near Avignon.

In the case of Italy, where the disease showed itself later but even more disastrously, affecting a much more extended industry, the loss in io years de Quatrefages stated at two milliards.

Roland's experience demonstrated that not cold but heat is the agent which saps the constitution of the silkworm and makes it a ready prey to disease.

Grasserie is another form of disease incidental to the silkworm.

In some parts of North America it is found that the white peaches are much less liable to the attack of a disease known as the "yellows" than are the yellow-fleshed ones.

A widespread disease known as pocket-plums or bladderplums is due to an ascomycetous fungus, Exoascus pruni, the mycelium of which lives parasitically in the tissues of the host plant, passes into the ovary of the flower and causes the characteristic malformation of the fruit which becomes a deformed, sometimes curved or flattened, wrinkled dry structure, with a hollow occupying the place of the stone; the bladder plums are yellow at first, subsequently dingy red.

The reproductive spores are borne in sacs (asci) which form a dense layer on the surface, appearing like a bloom in July; they are scattered by the wind and propagate the disease.

The spots are not often so numerous as to do much harm to the leaves, but where the disease is serious diseased leaves should be collected and burned.

But he had to be constantly guarded, his acquaintances were hampered from seeing him, and he was the victim of a painful disease, of which he died on the 1st of April 1894.

Peronosporaceae are a group of endophytic parasites - about ioo species - of great importance as comprising the agents of "damping off" disease (Pythium), vine-mildew (Plasmopara), potato disease (Phytophthora), onion-mildew (Peronospora).

Famine and disease soon began to tell their tale.

Nine British officers were killed in action, forty-three were wounded, and six died of disease.

The employment of barbarians as foederati, which became a common practice with the emperors in the 4th century, was both a symptom of disease in the body politic of the empire and a hastener of its impending ruin.

The drug is contra-indicated in all cases where the heart is already beating too slowly; in aortic incompetence - where the prolongation of diastole increases the amount of the blood that regurgitates through the incompetent valve; in chronic Bright's disease and in fatty degeneration of the heart - since nothing can cause fat to become contractile.

This post he retained till his death suddenly from heart disease on the 23rd of December 1834.

Nor could it ever have been doubted that war, disease, poverty the last two often the consequences of vice - are causes which keep population down.

The comte de Beaujolais was ill of the same disease and in 1808 the duke took him to Malta, where he died on the 29th of May.

No permanent success was attained till about 1876, when the disastrous effects of the coffee-leaf disease forced planters to give serious attention to tea.

At that date this disease was stamped out by energetic measures on the part of the government, but it has reappeared again in recent years, introduced apparently from India or Persia by pilgrims. There are four great centres of pilgrimage for Shiite Moslems in the vilayet, Samarra, Kazemain, a suburb of Bagdad, Kerbela and Nejef.

Unpleasant, but not dangerous, is another disease, the so-called "Bagdad date-mark," known elsewhere as the "Aleppo button," &c. This disease extends along the rivers Tigris and Euphrates, and the country adjacent from Aleppo and Diarbekr to the Persian Gulf, although there are individual towns and regions in this territory which seem to be exempt.

What may be called his last illness began as early as 1658, and as the disease progressed it was attended with more and more pain, chiefly in the head.

Under the influence of his disease, his senses became morbidly torpid, and his imagination morbidly active.

He was staying at a Moscow hotel, on his way from Minsk to his estate close by, when he died suddenly of heart disease on the 7th of July 1882.

The first campaign, however, which he conducted in person was a dismal failure; the Turks followed the Austrian army, disorganized by disease, across the Danube, and though the transference of the command to the veteran marshal Loudon somewhat retrieved the initial disasters, his successes were more than counterbalanced by the alliance, concluded on the 3 1st of January 1790, between Prussia and Turkey.

The bad harvest and the potato disease drove him to the repeal of the Corn Laws, and at a meeting in Manchester on 2nd July 1846 Cobden moved and Bright seconded a motion dissolving the league.

The prescriptions are for a great variety of ailments and afflictionsdiseases of the eye and the stomach, sores and broken bones, to make the hair grow, to keep away snakes, fleas, &c. Purgatives and diuretics are particularly numerous, and the medicines take the form of pillules, draughts, liniments, fumigations, &c. The prescriptions are often fanciful and may thus bear some absurd relation to the disease to be cured, but generally they would be to some extent effective.

On the 22nd of November the sultan died of disease at Manpira, but his death was carefully concealed by the amirs Ljin and Aktai, acting in concert with the Queen Shajar al-durr, till the arrival from Syria of the heir to the throne, Transhk, who was proclaimed some four months later.

Famine and disease broke out in Khatem Musas camp in 1895, and a retreat was made towards Kordofan.

They similarly possess power to repair and to regenerate their cell branches where these are injured or destroyed by trauma or disease.

A reeling gait, oscillations of the body which impart a zigzag direction to the walk, difficulty in standing, owing to unsteadiness of limb, are common in cerebellar disease.

A remarkable case is well authenticated, where, owing to disease, a young man had lost the use of all the senses save of one eye and of one ear.

The swarms of flies and insects, which next appear, are the natural outcome of the decaying masses of frogs, and these, in turn, would form a natural medium for the spread of cattle disease.

Disease and depopulation resulted from this policy and at the end of the 18th century the Legislative Assembly decided to reduce the area of the pools which then covered twice their present extent.

Information and statements including those regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

Birth is attended with pain, decay is painful, disease is painful, death is painful.

No sooner has an individual become separate, become an individual, than disease and decay begin to act upon it.

The Five Hindrances are (1) Hankering after worldly advantages, (2) The corruption arising out of the wish to injure, (3) Torpor of mind, (4) Fretfulness and worry, (5) Wavering of mind.'" When these five hindrances have been cut away from within him, he looks upon himself as freed from debt, rid of disease, out of jail, a free man and secure.

Disease and death were often connected with the violation of taboo, the offended gods thus punishing the offenders.

Pasteur prosecuted his investigations into the silkworm disease at Alais, and the town has dedicated a bust to his memory.

Inhalations of the gas are of service in pneumonia, bronchitis, heart disease, asthma, angina and other conditions accompanied by cyanosis and dyspnoea.

In this way the disease is spread rapidly, continually eating into the timber, which is first rendered brittle, and then reduced to powder.

Its geographical distribution is of the widest, and its rapidity of breeding, in manure and dooryard filth, so great that, as a carrier of germs of disease, especially cholera and typhoid, the house-fly is now recognized as a potent source of danger; and various sanitary regulations have been made, or precautions suggested, for getting rid of it.

On this account malarial subjects living in the Persian Gulf should take especial care to have an effective course of treatment in order to eradicate the disease as far as possible.

Beri-beri is a dietetic deficiency disease which manifests itself by cardiac weakness with shortness of breath, swelling of the legs and peripheral neuritis with numbness of the limbs and weakness.

The climatic conditions of the Persian Gulf particularly seem to predispose to this disease, for it very frequently attacks white persons resident there, especially if they are exposed to dietetic hardships.

Residents in the towns along the Persian Gulf are exposed to the same dangers from disease as are experienced in similar places in Mesopotamia and Persia (see Mesopotamia and Persia).

Thus malaria and sand-fly fever, dysentery, typhoid and paratyphoid fever, cholera, smallpox, and occasionally typhus fever, eye diseases, oriental sores and indeed any disease conveyed by impure water, flies, contaminated dust or the contagion of sufferers from infectious diseases, are prevalent in the inhabited places along the Persian Gulf, and precautions must always be taken to guard against them.

In 1853, however, the grape disease attacked the vineyards; and thenceforward the production of cochineal, which had been introduced in 1825, took the place of viticulture so completely that, twenty years later, the exports of cochineal were worth £556,000.

In 1900-1901 Major Walter Reed (1851-1902), a surgeon in the United States army, proved by experiments on voluntary human subjects that the infection was spread by the Stegomyia mosquito,' and the prevention of the disease was then undertaken by Major William C. Gorgas - all patients being screened and mosquitoes practically exterminated.'

In the course of the 17th century the port became the great 1 Dr Carlos Finlay of Havana, arguing from the coincidence between the climatic limitation of yellow fever and the geographical limitation of the mosquito, urged (1881 sqq.) that there was some relation between the disease and the insect.

Carter (U.S. Marine Hospital Service) that although the incubation of the disease was 5 days, 15 to 20 days had to elapse before the "infection" of the house, and from Ross's demonstration of the part played in malaria by the Anopheles.

The people have by no means that immunity from disease which the bright, dry character of the climate and the fine physical aspect of a large proportion of them might lead us to expect.

Having long suffered from a terrible disease, he died in 1773, bequeathing to his son Timur a dominion which embraced not only Afghanistan to its utmost limits, but the Punjab, Kashmir and Turkestan to the Oxus, with Sind, Baluchistan and Khorasan as tributary governments.

Owing to disease among the silk-worms the industry has declined of recent years; and in 1886 an inquiry was held, which resulted in putting the silk-rearing industry of Bengal on a better basis.

The tea outlook was good, and the coffee industry was recovering from the effects of plant disease and Brazilian competition.

The war went on with varying success, until Charles of Valois, summoned by the pope to conduct the campaign, landed in Sicily and, his army being decimated by disease, made peace with Frederick at Caltabellotta (1302).

He retired to Rome, where he was imprisoned in the castle of St Angelo for six months for his disobedience to the papal orders, and died in 1817, a year or two after his release, of disease contracted in prison and of chagrin.

But he died before the suit was decided (it is said in consequence of disease caught at the camp of La Rochelle, whither he had gone to petition the king), in Paris, on the 16th of October, 1628, at the age of seventythree.

He had enough men, though a number of his units were below strength, while others were battle-worn and others again had suffered much from an intestinal disease that had been prevalent in the valleys of the Natisone and the Judrio; and he had enough guns, in spite of the withdrawal of the Allied artillery, though he would doubtless have been glad of a larger reserve.

About 50,000 men were killed in Virginia, and probably ioo,000 died of wounds and disease.

It must not be employed in cases of renal disease, owing to the risks attendant upon absorption.

They infected the animals in the town with the vamp disease.

Death dealers were immune to disease, poison, and any other thing humans could throw at them.

My beautiful bride labored to the end, administrating to the fallen and the flu stricken souls of our town until she too, fell to the scourge of this most dreaded disease.

The results of these first experiments were not encouraging, owing mainly to the poor class of animals, but the exporters persevered, and the business steadily grew in value and importance, until in 1898 the number of live cattle shipped was 359,296, which then decreased to 119,189 in 1901, because of the foot-and-mouth disease.

Pythium, which causes the damping off of seedlings, reducing them to a putrid mass in a few hours, and Phytophthora, the agent of the potato disease.

Carbolic acid is an efficient parasiticide, and is largely used in destroying the fungus of ringworm and of the skin disease known as pityriasis versicolor.

Despite the general recognition of these facts, the pharmacology of colchicum has hitherto thrown no light on the pathology of gout, and the pathology of gout has thrown no light upon the manner in which colchicum exerts its unique influence upon this disease.

When sulphur is burned in air or oxygen, sulphur dioxide is produced, which is a powerful disinfectant, used to fumigate rooms which have been occupied by persons suffering from some infectious disease.

Russia, was reduced to a very low ebb, in consequence of the silkworm disease, and was only renewed with any vigour towards the end of the 'eighties.

In the same year he was made archbishop of Besancon, but meanwhile he had been stricken with a lingering disease; he was never enthroned, but died at Madrid on the 21st of September 1586.

Of the mortality due to malarial disease a small part only is referable to the direct attack of intermittent, and chiefly to the fever in its pernicious form.

From the time of Hippocrates onwards the malarial or periodical fevers have engaged the attention of innumerable observers, who have suggested various theories of causation, and have sometimes anticipated - vaguely, indeed, but with surprising accuracy - the results of modern research; but the true nature of the disease remained in doubt until the closing years of the 19th century.

The alleged occurrence of the disease in localities free from mosquitoes or without their agency is not well attested; its absence from other localities where they abound is accounted for by their being of an innocent species, or - as in England - free from the parasite.

He has pointed out that certain areas and certain islands are entirely free from the disease, while neighbouring areas and islands are devastated.

If this factor could be discovered it might be applied to the suppression of the disease in malarious localities.

Herod was stricken with an incurable disease.

Among hospitals are the Italian, the Homoeopathic, the National for the paralysed and epileptic, the Alexandra for children with hip disease, and the Hospital for sick children.

He was the son of Richard Bright, the physician who first diagnosed " Bright's disease " in 1827, and his mother was Eliza Follett, sister of Sir William Follett, who was solicitor-general and attorney-general in Peel's administration (1834-44).

What was the secret power which enabled him to bring under the domain of scientific laws phenomena of disease which had so far baffled human endeavour?

Dumas, a native of the Alais district, where the disease was rampant, urged Pasteur to undertake its investigation.

Up to that time he had never seen a silkworm, and hesitated to attempt so difficult a task; but at the reiterated request of his friend he consented, and in June 1865 went to the south of France for the purpose of studying the disease on the spot.

The first disease investigated by Pasteur was that of chicken cholera, an epidemic which destroyed io% of the French fowls; after the application of the preventive method the death-rate was reduced to below i %.

But while the province in many parts presents a landscape of luxuriant beauty, it is a prey to the ravages of disease, principally malarial fevers due to the extensive swamps formed by waters stagnating in the forests, and to the frequent incursions of the Goklan and Yomut Turkomans, who have their camping-grounds in the northern part of the province, and until about 1890 plundered caravans sometimes at the very gates of Astarabad city, and carried people off into slavery and bondage.

As in .` the case of the apple disease it forms large irregular blackish blotches on the fruit and leaves, the injury being often very severe especially in a cool, damp season.

The fungus mycelium grows between the cuticle and the epidermis, the former being ultimately ruptured by numerous short branches bearing spores (conidia) by means of which the disease is spread.

During the middle ages cattle and sheep were the chief farm animals, but the intermixture of stock consequent on the common-field system was a barrier to improvement in the breed and conduced to the propagation of disease.

The foot-and-mouth disease first appeared about 1840, having been introduced, as is supposed, by foreign cattle.

Several weeks elapsed before the true character of the disease was known, and in this brief space it had already been carried by animals purchased in Smithfield market to all parts of the country.

In 1883 foot-and-mouth disease was terribly rampant amongst the herds and flocks of Great Britain, and was far more prevalent than it has ever been since.

It was about this time that the value of a mixture of lime and sulphate of copper (bouillie bordelaise), sprayed in solution upon the growing plants, came to be recognized as a check upon the ravages of potato disease.

The effect was to reduce to a minimum the risk of the introduction of disease amongst the herds and flocks of the country, and at the same time to confine the trade in store stock exclusively to the breeders of Great Britain and Ireland.

In 1900 the discovery early in the year of the existence of foot-and-mouth disease amongst cattle and sheep shipped from Argentina to the United Kingdom led to the issue of an order by which all British ports were closed against live animals from the country named.

The course of foot-and-mouth disease in Great Britain between 1877 and 1905 inclusive is told in Table XX., from which the [[Table Xx]].

The disease is seen to have attained its maximum virulence in 1883.

For its size and in relation to its sheep population Wales harbours the disease to a far greater extent than the other divisions of Great Britain.

The fatal disease known as anthrax did not form the subject of official returns previous to the passing of the Anthrax Order of 1886.

A recrudescence of the disease marked the closing years of the 19th century, the outbreaks having been 748 in 1898, 853 in 1899 and 1119 in 1900.

The disease was very rife in 1895, but the extensive application of the muzzling restrictions of the Board of Agriculture was accompanied by so steady a diminution in the [[Table Xxii I]].

The trouble with this disease has been mainly in England, the outbreaks in Wales and Scotland being comparatively few.

Animals suffer from the ravages of bot flies (Oestridae) and gad flies (Tabanidae); while the tsetse disease is due to the tsetse fly (Glossina morsitans), carrying the protozoa that cause the disease from one horse to another.

Having thereby greatly offended the king, he was accused of being privy to a treasonable conspiracy and thrown into prison, where he died from torture or disease.

While engaged on this task he died, worn out with disease, on the 3rd of March 1703 in London, and was buried in St Helen's Church, Bishopsgate Street.

Thus the Mintra of the Malay Peninsula have a demon corresponding to every kind of disease known to them; the Tasmanian ascribed a gnawing pain to the presence within him of the soul of a dead man, whom he had unwittingly summoned by mentioning his name and who was `devouring his liver; the Samoan held that the violation of a food tabu would result in the animal being formed within the body of the offender and cause his death.

This theory of disease disappeared sooner than did the belief in possession; the energumens (EVEp-yoiwEvoc) of the early Christian church, who were under the care of a special clerical order of exorcists, testify to a belief in possession; but the demon theory of disease receives no recognition; the energumens find their analogues in the converts of missionaries in China, Africa and elsewhere.

Another way in which a demon is held to cause disease is by introducing itself into the patient's body and sucking his blood; the Malays believe that a woman who dies in childbirth becomes a langsuir and sucks the blood of children; victims of the lycanthrope are sometimes said to be done to death in the same way; and it is commonly believed in Africa that the wizard has the power of killing people in this way, probably with the aid of a familiar.

The resistance was well maintained in succeeding generations, and races so raisedDform a practical means of combating this serious disease.

No remedy is known for the disease, and cotton should not be planted on infected land for at least three or four years.

Thus sometimes a field of cotton is attacked by some disease, perhaps " wilt," and a comparatively few plants are but very slightly affected.

The eggs are now too much in one basket, and local disease, or bad weather, or some other misfortune, may diminish by serious percentages the supplies anticipated.

Medical science has never gauged, perhaps never enough set itself to gauge the intimate connexion between moral fault and disease.

Epidemics of smallpox and typhoid occur; and leprosy, imported from the Orange River and Cape Colonies, has taken firm hold on the Basuto, of whom about 9r per too() are sufferers from this disease.

He seems to have touched at the island of Tortugas, so named on account of the large number of turtles found there, and to have landed at several places, but many of his men succumbed to disease and he himself was wounded in an Indian attack, dying soon afterward in Cuba.

The anxiety, fatigue and cold to which he was thus exposed, affecting a constitution naturally weak, laid the foundation of the disease to which he afterwards succumbed.

A violent rebellion is mentioned in 1788, put down only after the loss, it is said, of ioo,000 men by disease and sword, and the expenditure of 2,000,000 taels of silver.

The hero is smitten with sore disease, but the fragmentary condition of this and the succeeding tablet is such as to envelop in doubt the accompanying circumstances, including the cause and nature of his disease.

This is apt to be met with in oldish persons with diseased vessels and feeble heart-action, especially if the blood is rendered less nutritious by the presence of diabetes or of kidney disease.

Froissart relates that he was burned to death through his bedclothes catching fire; Secousse says that he died in peace with many signs of contrition; another story says he died of leprosy; and a popular legend tells how he expired by a divine judgment through the burning of the clothes steeped in sulphur and spirits in which he had been wrapped as a cure for a loathsome disease caused by his debauchery.

It was in far later periods and in other countries that the appearance of the dogstar was regarded as the signal of insufferable heat or prevalent disease.

Yellow fever (which first appeared in Cuba in 1647) was long the only epidemic disease, Havana being an endemic focus.

The Cuban coast was uninterruptedly full of infection, and the danger of an outbreak in each year was never absent, until the work of the United States army in 1901-1902 conclusively proved that this disease, though ineradicable by the most extreme sanitary measures, based on the accepted theory of its origin as a filth-disease, could be eradicated entirely by removing the possibility of inoculation by the Stegomyia mosquito.

Of other agricultural crops those of fruits are of greatest importance - bananas (which are planted about once in three years), pine-apples (planted about once in five years), coco-nuts, oranges, &c. The coco-nut industry has long been largely confined to the region about Baracoa, owing to the ruin of the trees elsewhere by a disease not yet thoroughly understood, which, appearing finally near Baracoa, threatened by 1908 to destroy the industry there as well.

Here he was attacked by Wellington (March 29) and, after a further engagement at Sabugal (April 3, 1811), he fell back through Ciudad to Salamanca, having lost in Portugal nearly 30,000 men, chiefly from want and disease, and 6000 in the retreat alone.

The malady causing the greatest number of deaths is that of pulmonary consumption; but better housing accommodation has of late years reduced the mortality from this disease very considerably.

His mother had suffered from phthisis; and he himself now fell a victim to the same disease.

After this every portion of the animal is thoroughly examined, for if there is any organic disease the devout Jew cannot taste the meat.

Whilst absolutely contra-indicated in all cases of valvular disease, it is of value in cases of cardiac hypertrophy with over-action.

During the six weeks previous to the relief, 200 deaths had occurred from disease alone, and altogether as many as 8424 were reported to have passed through the hospitals.

But even at this stage the disease may be unrecognizable, though the symptoms are extremely suggestive.

But in many cases the patient prefers that the abdomen should be opened for exploration for a possible operation than that he should hopelessly give himself over to the disease.

In some early cases of pyloric cancer resection of the disease may be performed, the upper end of the intestine being afterwards joined to the middle of the stomach by a kind of short-circuiting operation.

His frame was sickly and wasted with disease, yet when clad in his red cardinal's.

Herodotus mentions the existence of this class, called Enarees, and says that they suffer from a sacred disease owing to the wrath of the goddess of Ascalon whose shrine they had plundered.

The asphodel was also supposed to be a remedy for poisonous snake-bites and a specific against sorcery; it was fatal to mice, but preserved pigs from disease.

Six species of tick, including the blue tick common throughout South Africa, are found, especially in the low veld, where they are the means of the transmission of disease to cattle.

The disease was first known in Europe among the Italian workmen employed on the St Gotthard tunnel.

The American parasite described by Stiles, and called Uncinaria americana (whence the name Uncinariasis for this disease) differs slightly from the Ankylostoma.

Influenced by the prevailing philosophy of the day, they interpreted the phenomena of disease through its lights, and endeavoured from time to time to reduce the study of pathology to philosophical order when the very elements of philosophical order were wanting.

The complexity and mystery of action inherent in living matter have probably been accountable for much of the vague philosophy of disease in the past, and have furnished one reason at least why pathology has been so long in asserting its independence as a science.

The healthy bone marrow reacts with remarkable rapidity to the demand for more blood cells which may be required by the organism; its reactions and variations in disease are very striking.

Pneumonia of the croupous type has been proved to be, as a rule, a germ disease, the nature of the germ varying according to circumstances.

It wastes in the disease known as " myxoedema," and the above product gathers in the tissues, in that disease, to such an extent as to give rise to what has been termed a " solid oedema."

When the pancreas is excised in an animal, or when it is destroyed in man by disease, grape-sugar appears in the urine.

Pathology is the science of disease in all its manifestations, whether structural or functional, progressive or regressive.

Our range must embrace a much wider area - must comprise, in fact, all living matter - if we are ever to arrive at a scientific conception of what disease really means.

Disease as an entity - as something to which all living matter is subject - is what the pathologist has to recognize and to investigate, and the practical application of the knowledge thus acquired follows as a natural consequence.

Disease we may define, accordingly, as any departure from the normal standard of structure or function of a tissue or organ.

If, for instance, we find that instead of the natural number of Malpighian bodies in the kidney there are only half that number, then we are entitled to say that this defect represents disease of structure; and if we find that the organ is excreting a new substance, such as albumen, we can affirm logically that its function is abnormal.

Once grant the above definition of disease, and even the most trivial aberrations from the normal must be regarded as diseased conditions, quite irrespective of whether, when structural, they interfere with the function of the part or not.

Thus an abortive supernumerary finger may not cause much, if any, inconvenience to the possessor, but nevertheless it must be regarded as a type of disease, which, trivial as it may appear, has a profound meaning in phylogeny and ontogeny.

The term " pathogenesis " has reference to the generation and development of disease, and that of " aetiology," in its present bearing, has to do with its causes.

Or again, in the case of paired organs, if one be removed by operation, or destroyed by disease, the other at once undertakes to carry on the functions of both.

There can be little doubt that all unnatural and artificial modes of life tend to deterioration of the powers of resistance of the organism to disease.

Whenever these conditions are infringed his powers of resistance to disease are lessened, and certain tendencies begin to show themselves, which are generally termed constitutional.

Thus the liability to tubercular infection is far commoner in the midst of a depraved population than in one fulfilling the primary laws of nature; rickets is a disease of great cities rather than of rural districts; and syphilis is more disastrous and protracted in its course in the depraved in health than in the robust.

Every living organism, animal and vegetable, tends to maintain a normal state of health; it is when the natural laws of health are violated that the liability to disease begins to assert itself.

The abuse of alcohol may also be mentioned here as a factor in the poduction of disease.

The tendencies to disease are in great part hereditary.

A distinction must be drawn between the above and diseases, like syphilis and small-pox, in which the contagion of, not the tendency to, the disease is transmitted directly to the foetus in utero.

According to our present knowledge of physiological and pathological processes, we must regard the cell as the ultimate biological unit - a unit of structure and a unit of function; this was first put forward by Schleiden in 1838, and by Schwann in 1839, but we owe to Virchow the full recognition of the fundamental importance of the living cell in all the processes of life, whether in health or disease.

They held that the cirrhotic kidney is simply a local manifestation of a general fibrous disease.

Their investigations on cancers found in the lower animals, and the successful transplantation of such growths into a new host of the same species (mice and rats), have greatly advanced our knowledge of the etiology of this disease.

Certain degenerative changes in the supra-renal glands may lead to Addison's disease, which is characterized by an excessive pigmentary condition of the skin and mucous membranes.

Amyloid develops in various organs and tissues and is commonly associated with chronic phthisis, tubercular disease of bone and joints, and syphilis (congenital and acquired).

Nowak, however, found later that he could generate it where the turpentine failed to induce suppuration; he believes that it may arise quite apart from the influence of the organisms of suppuration, that it is not a biological product of the micro-organisms of disease, and also that it has nothing to do with emaciation.

So long as the epidermis of animals remains sound, disease germs may come in contact with it almost with impunity, but immediately on its being fissured, or a larger wound made through it, the underlying parts, the blood and soft tissues, are attacked by them.

It is invariably the result of some cause acting generally, such as renal disease, valvular defect of the heart, or an impoverished state of the blood; while a mere oedema is usually dependent upon some local obstruction to the return of blood or lymph, or of both, the presence of parasites within the tissue, such as the filaria sanguinis hominis or trichina spiralis, or the poisonous bites of insects.

Bainbridge suggests that a retention of metabolic products may cause the oedema in renal disease, Bradford having previously shown that loss of a certain amount of renal tissue caused retention of metabolic products in the tissues.

When, for instance, the cause of septic infection had been revealed, the prophylaxis of the disease became a possibility.

The whole system of treatment of tubercular disease has been altered by the discovery of the tubercle microphyte.

The treatment of the disease has now gone off in the opposite direction.

The discovery of the parasite of malaria by Laveran, and of the method by which it gains entrance to the human body, through the bite of a particular variety of mosquito, by Manson and Ross, promises much in the way of eradication of the disease in the future.

By the continuous injections under the skin, in increasing doses, of the toxins of certain pathogenic micro-organisms, such as that of diphtheria, an animal-usually the horse-may be rendered completely refractory to the disease.

Skin-grafting and regeneration of bone are among not the least remarkable applications of pathological principles to the combat with disease in recent times; and in this connexion may also be mentioned the daring acts of surgery for the relief of tumours of the brain, rendered practicable by improved methods of localization.

Taking disease to be a deflexion from the line of health, the first requisite of medicine is an extensive and intimate acquaintance with the norm of the body.

Here we recognize the true Greek But this artistic completeness was closely connected with the third cardinal virtue of Hippocratic medicine - the clear recognition of disease as being equally with life a process governed by what we should now call natural laws, which could be known by observation, and which indicated the spontaneous and normal direction of recovery, by following which alone could the physician succeed.

In the fourth place, these views of the "natural history of disease" (in modern language) led to habits of minute observation and accurate interpretation of symptoms, in which the Hippocratic school was unrivalled in antiquity, and has been the model for all succeeding ages, so that even in these days, with our enormous advances in knowledge, the true method of clinical medicine may be said to be the method of Hippocrates.

The most valuable intellectual possession was a large mass of recorded observations in individual cases and epidemics of disease.

The dominating theory of disease was the humoral, which has never since ceased to influence medical thought and practice.

According to this celebrated theory, the body contains four humours - blood, phlegm, yellow bile and black bile, a right proportion and mixture of which constitute health; improper proportions or irregular distribution, disease.

The duty of the physician was to foresee these changes, "to assist or not to hinder them," so that "the sick man might conquer the disease with the help of the physician."

It follows from what has been said that prognosis, or the art of foretelling the course and event of the disease, was a strong point with the Hippocratic physicians.

Diagnosis, or recognition of the disease, must have been necessarily imperfect, when no scientific nosology or system of disease existed, and the knowledge of anatomy was quite inadequate to allow of a precise determination of the seat of disease; but symptoms were no doubt observed and interpreted skilfully.

In the treatment of disease, the Hippocratic school attached great importance to diet, the variations necessary in different diseases being minutely defined.

He appears to have leaned to mechanical explanations of the symptoms of disease, as was especially the case with inflammation, of which he gave the first rational, though necessarily inadequate, theory.

The most striking peculiarity of the empirics was that they rejected anatomy, regarding it as useless to inquire into the causes of things, and thus, as they contended, being the more minute in their observation of the actual phenomena of disease.

They had from early times a very complicated system of superstitious medicine, or religion, related to disease and the cure of disease, borrowed, as is thought, from the Etruscans; and, though the saying of Pliny that the Roman people got on for six hundred years without doctors was doubtless an exaggeration, and not, literally speaking, exact, it must be accepted for the broad truth which it contains.

In the treatment of disease Asclepiades attached most importance to diet, exercise, passive movements or frictions, and the external use of cold water - in short, to a modified athletic training.

His knowledge of disease and surgical skill were, as appears from the accounts given by Celsus and Caelius Aurelianus, very considerable.

Its main principles were that it was useless to consider the causes of a disease, or even the organ affected by the disease, and that it was sufficient to know what was common to all diseases, viz.

Besides this it was important only to consider whether the disease was acute or chronic, whether it was increasing, declining or stationary.

Treatment of disease was directed not to any special organ, nor to producing the crises and critical discharges of the Hippocratic school, but to correcting the morbid common condition or "community," relaxing the body if it was constricted, causing contraction if it was too lax, and in the "mixed state" acting according to the predominant condition.

In his anatomical studies Galen had a twofold object - a philosophical, to show the wisdom of the Creator in making everything fit to serve its purpose; and a practical, to aid the diagnosis, or recognition, of disease.

From faulty proportions of the same arose the intemperies (" distempers"), which, though not diseases, were the occasions of disease.

His works have been much admired for the purity of the Greek style, and his accurate descriptions of disease; but, as he quotes no medical author, and is quoted by none before Alexander of Aphrodisias at the beginning of the 3rd century, it is clear that he belonged to no school and founded none, and thus his position in the chain of medical tradition is quite uncertain.

Then some remedy had to be introduced which should be antagonistic, not to the disease in a physical sense, but to the spiritual seed of the disease.

These remedies were arcana - a word corresponding partly to what we now call specific remedies, but implying a mysterious connexion between the remedy and the "essence" of the disease.

Among many descriptions of this disease, that by John Kaye or Caius, already referred to, was one of the best, and of great importance as showing that the works of Galen did not comprise all that could be known in medicine.

The spread of syphilis, a disease equally unknown to the ancients, and the failure of Galen's remedies to cure it, had a similar effect.

Inspections of the dead, to ascertain the nature of the disease, were made, though not without difficulty, and thus the modern period of the science of morbid anatomy was ushered in.

These discoveries not only weakened or destroyed the respect for authority in matters of science, but brought about a marked tendency to mechanical explanations of life and disease.

At the same time the discovery of new diseases, unknown to the ancients, and the keener attention which the great epidemics of plague caused to be paid to those already known, led to more minute study of the natural history of disease.

The most important disease hitherto undescribed was rickets, first made known by Arnold de Boot, a Frisian who practised in Ireland, in 1649, and afterwards more fully in the celebrated work of Francis Glisson (1597-1677) in 1651.

The principle which mainly distinguished it was not merely the use of chemical medicines in addition to the traditional, or, as they were called in distinction, "Galenical" remedies, but a theory of pathology or causation of disease entirely different from the prevailing "humoral" pathology.

The "intestine movement of particles" in every body, or fermentation, was the explanation of many of the processes of life and disease.

He resembled his Greek master in the high value he set on the study of the "natural history of disease"; in the importance he attached to "epidemic constitution" - that is, to the influence of weather and other natural causes in modifying disease; and further in his conception of the healing power of nature in disease, a doctrine which he even expanded beyond the teaching of Hippocrates.

According to Sydenham, a disease is nothing more than an effort of nature to restore the health of the patient by the elimination of the morbific matter.

The reform of practical medicine was effected by men who aimed at, and partly succeeded in, rejecting all hypothesis and returning to the unbiassed study of natural processes, as shown in health and disease.

This phase is most clearly developed in Archibald Pitcairne (1652-1713), who, though a determined opponent of metaphysical explanations, and of the chemical doctrines, gave to his own rude mechanical explanations of life and disease almost the dogmatic completeness of a theological system.

Mead's treatise on The Power of the Sun and Moon over Human Bodies (1704), equally inspired by Newton's discoveries, was a premature attempt to assign the influence of atmospheric pressure and other cosmical causes in producing disease.

The symptoms of disease were explained as efforts of the soul to rid itself from morbid influences, the soul acting reasonably with respect to the end of self-preservation.

The latter had, in neglecting anatomy, neglected the most solid basis for studying the natural history of disease; though perhaps it was less from choice than because his practice, as he was not attached to a hospital, gave him no opportunities.

While thus rejecting all the lessons of morbid anatomy and pathology, he put forward views respecting the causes of disease which hardly bear to be seriously stated.

All chronic maladies result either from three diseasespsora (the itch), syphilis or sycosis (a skin disease), or else are maladies produced by medicines.

In order to select remedies which should fulfil the indication of producing symptoms like those of the disease, Hahnemann made many observations of the action of drugs on healthy persons.

In the treatment of disease his practical innovations came at a fortunate time, when the excesses of the depletory system had only partially been superseded by the equally injurious opposite extreme of Brown's stimulant treatment.

This, the old "Vienna School," was not distinguished for any notable discoveries, but for success in clinical teaching, and for its sound method of studying the actual facts of disease during life and after death, which largely contributed to the establishment of the "positive medicine" of the 19th century.

The importance in science of Bichat's classical works, especially of the Anatomie generale, cannot be estimated here; we can only point out their value as supplying a new basis for pathology or the science of disease.

In his Zoonomia (1794) he expounded a theory of life and disease which had some resemblance to that of Brown, though arrived at (he says) by a different chain of reasoning.

The discovery by Richard Bright (1789-1858) of the disease of the kidneys known by his name proved to be one of the most momentous of the century.

In no department is the experimental method more continually justified than in that of the natural history of disease, which at first sight would seem to have a certain independence of it and a somewhat exclusive value of its own.

If at first in the 18th century, and in the earlier 19th, the discoveries in this branch of medical knowledge had a certain isolation, due perhaps to the prepossessions of the school of Sydenham, they soon became the property of the physician, and were brought into co-ordination with the clinical phenomena of disease.

Not only so, but the physician, thus fascinated by "types," and impressed by the silent monumentsof the pathological museum, was led to localize disease too much, to isolate the acts of nature, and to forget not only the continuity of the phases which lead up to the exemplary forms, or link them together, but to forget also that even between the types themselves relations of affinity must exist - and these oftentimes none the less intimate for apparent diversities of form, for types of widely different form may be, and indeed often are, more closely allied than types which have more superficial resemblance - and to forget, moreover, how largely negative is the process of abstraction by which types are imagined.

Thus it came about not only that classifications of disease based on superficial likeness - such as jaundice, dropsy, inflammation - were broken up, and their parts redistributed, but also that even more set diseases began to lose their settlements, and were recognized as terms of series, as transitory or culminating phases of perturbations which might be traced to their origins, and in their earlier stages perhaps withstood.

These new conceptions of the multiplicity in unity of disease, and of the fluidity and continuity of morbid processes, might have led to vagueness and over-boldness in speculation and reconstruction, had not the experimental method been at hand with clues and tests for the several series.

In the disease of the scalp called favus, Schonlein had discovered a minute mycelial fungus; a remarkable discovery, for it was the first conspicuous step in the attribution of diseases to the action of minute parasites.

Of the older ontological notions of disease the strongest were those of the essence of fever and of the essence of inflammation.

As to such reforms in our conceptions of disease the advances of bacteriology profoundly contributed, so under the stress of consequent discoveries, almost prodigious in their extent and revolutionary effect, the conceptions of the etiology of disease underwent no less a transformation than the conceptions of disease itself.

It is proper to point out here how intimately a pathology thus regenerated modified current conceptions of disease, in the linking of disease to oscillations of health, and the regarding many diseases as modifications of the normal set up by the impingement of external causes; not a few of which indeed may be generated within the body itself - "autogenetic poisoning."

By the modification of physical conditions on a national scale a prodigious advance was made in the art of preventing disease.

The 10th century, by means of this illumination of one of the darkest regions of disease, may diminish human suffering enormously, and may make habitable rich and beautiful regions of the earth's surface now, so far as man's work is concerned, condemned to sterility.

Moreover, freedom of trade and of travel has been promoted by a reform of the antiquated, cumbrous, and too often futile methods of quarantine - a reform as yet very far from complete, but founded upon a better understanding of the nature and propagation of disease.

Thus the field of disease arising not from essential defect in the body, but from external contingencies, is vastly enlarging; while on the other hand the great variability of individuals in susceptibility explains the very variable results of such extrinsic causes.

This law has important ethical and political bearings; but in the province of disease this advance of what may be compared to the interlocking of points and signals has had wide influence not only in altering our conceptions of disease, but also in enlarging our views of all perturbations of function.

By similar methods nature, unassisted, betrays herself but too often; in many instances - probably originating primarily in the nervous tissues themselves - the course of disease is observed to follow certain paths with remarkable consistency, as for instance in diseases of particular tracts of the spinal cord.

It is needless to point out how such paths of disease, in their association with characteristic symptoms, have illuminated the clinical features of disease as well as the processes of normal function.

In infantile palsy, for example, and in tabes dorsalis, there is good reason to believe of that, definitely as the traces of the disease are found in certain physiologically distinct nervous elements, they are due nevertheless to toxic agents arriving by way of the blood.

Some of the most successful of the advances of medicine as a healing art have followed the detection of syphilitic disease of the vessels, or of the supporting tissues of nervous centres and of the peripheral nerves; so that, by specific medication, the treatment of paralytic, convulsive, and other terrible manifestations of nervous disease thus secondarily induced is now undertaken in early stages with definite prospect of cure.

Griesinger (1817-1868), Bevan Lewis - and in the separation from insanity due to primary disease or defect of nerve elements of such diseases as general paralysis of the insane, which probably arise, as we have said, by the action of poisons on contiguous structures - such as blood-vessels and connective elements - and invade the nervous matter secondarily.

Sufferers from mental disease are still regarded too much as troublesome persons to be hidden away in humane keeping, rather than as cases of manifold and obscure disease, to be studied and treated by the undivided attention of physicians of the highest skill.

In heart disease the chief work of the latter half of the 19th century was, in the first quarter, such clinical work as that of William Stokes and Peter Mere Latham (1789-1875); and in the second quarter the fuller comprehension of the vascular system, central and peripheral, with its cycles and variations of blood pressure, venous and arterial.

To the discovery of the parts played in disease by thrombosis and embolism we have referred above.

It was in the management of pleurisies that the aid of surgical means first became eminent in inward disease.

In the department of abdominal disease progress has been made, not only in this enormous extension of means of cure by operative methods, but also in the verification of diagnosis.

The first recognition of a disease may be at a necropsy, but then usually by irresponsible pathologists; it is another matter when the physician himself comes under rebuke for failing to seize a way to cure, while the chance remained to him, by section of the abdomen during life.

The abdomen is still "full of surprises"; and he who has most experience of this deceptive region will have least confidence in expressing positive opinions in particular cases of disease without operative investigation.

Nor must we forget the unfolding of a new chapter of disease, in the nosology of the pancreas.

In diabetes this organ seems to play a part which is not yet precisely determined; and one fell disease at least has been traced to a violent access of inflammation of this organ, caused perhaps by entry of foreign matters into its duct.