Digeorge-syndrome Sentence Examples
Children with DiGeorge syndrome either do not have a thymus or have an underdeveloped thymus.
In some cases, no treatment is required for DiGeorge syndrome because T lymphocyte production improves.
In some cases, no treatment is required for DiGeorge syndrome because T lymphocyte production improves on its own.
The primary problem for children who survive with DiGeorge syndrome is repeated infections due to a defective immune system.
Specific facial features associated with DiGeorge syndrome include low-set ears, wide-set eyes, a small jaw, and a short groove in the upper lip.Advertisement
In the United States, autopsy studies for DiGeorge syndrome accounted for 0.7 percent of 3469 postmortem examinations in the Seattle, Washington, area over a period of 25 years.
No major difference is noted in the incidence of DiGeorge syndrome between males and females.
The deletion means that several genes from chromosome 22 are missing in children with DiGeorge syndrome.
According to a 1999 study, 6 percent of children with DiGeorge syndrome inherited the deletion from a parent, while 94 percent had a new deletion.
In addition, 74 percent of fetuses with DiGeorge syndrome have severe heart defects.Advertisement
Because the immune system of a child with DiGeorge syndrome is defective, a doctor should be consulted at any signs of illness or disease.
Diagnosis of DiGeorge syndrome can be made by ultrasound examination around the eighteenth week of pregnancy, when abnormalities in the development of the heart or the palate can be detected.
It confirms about 95 percent of cases of DiGeorge syndrome.
If the mother has not had prenatal testing, the diagnosis of DiGeorge syndrome is sometimes suggested by the child's facial features at birth.
The doctor may make the diagnosis of DiGeorge syndrome during heart surgery when he or she notices the absence or abnormal location of the thymus gland.Advertisement
Hypocalcemia in a child with DiGeorge syndrome is unusually difficult to treat.
Children with DiGeorge syndrome should be kept away from crowds or other sources of infection.
Children with DiGeorge syndrome should be kept on low-phosphorus diets.
The prognosis is variable; many infants with DiGeorge syndrome die from overwhelming infection, seizures, or heart failure within the first year.
Genetic counseling and testing is recommended for a person with DiGeorge syndrome who becomes pregnant, because the disorder can be detected prior to birth.Advertisement
Although most children with DiGeorge syndrome do not inherit the chromosome deletion from their parents, they have a 50 percent chance of passing the deletion on to their own children.
Parents should be screened, however, to see if they are carriers, even though inheritance of DiGeorge syndrome is rare.
Because of an association between DiGeorge syndrome and fetal alcohol syndrome, pregnant women should avoid drinking alcoholic beverages.
Recurrent infections are a major problem in children with DiGeorge syndrome and an important cause of later mortality.