How to use Defective in a sentence
The law is defective and unfair in its incidence, and it is not applicable to foreigners.
Any parts that are defective are replaced.
The size of the boiler may be increased or diminished by the addition or subtraction of one or more sections; these, being simple in design, are easily fitted together, and should a section become defective it is a simple matter to insert a new one in its place.
It is defective in every modern appliance.
They hunt entirely by sight, the sense of smell being defective.Advertisement
The glass is, however, by no means ready for delivery, since it has yet to be examined with scrupulous care, and all defective pieces must be rejected entirely or at least the defective part must be cut out and the slab remoulded or ground down to a smaller size.
The cubes fall from the cutting machine on to a riddling machine, which separates those which are defective in size from the rest.
The last twelve verses were added later still, probably early in the 2nd century, probably to take the place of the ending which had been lost, or which was regarded as defective.
Such a composite structure is, however, fundamentally defective, the distribution of loading to the two independent systems being indeterminate.
More favourable opinions of the work were expressed by others, but it is generally agreed that the author's scholarship is defective and that his views are far too conservative.Advertisement
Rendel Harris argued for the influence of Latin, and Chase for that of Syriac. While both threw valuable light on obscure points, it seems probable that they exaggerated the extent to which retranslation can be traced; that they ranked Codex Bezae somewhat too highly as the best witness to the " Western " text; and that some of their work was rendered defective by their failure to recognize quite clearly that the " Western " text is not a unity.
Average variation may be said to range from 1/40 to 1/70 in different units, doubtless greatly due to defective balances.
Some have represented Smith's work as of so loose a texture and so defective in arrangement that it may be justly described as consisting of a series of monographs.
The railway was first completed in 1894, but light and defective construction, together with lack of shipping facilities at its terminal points, rendered it useless.
She had been born with a defective version of the gene that normally makes the essential enzyme adenosine deaminase (ADA ).Advertisement
An overflow is provided, discharging into the open air to allow the water to escape should the ball valve become defective.
Their organization, however, in regard to their means of defence against both external aggression and internal violence, was extremely defective.
Glass is made in several parts of India - as Patna and Mysore - by very simple and primitive methods, and the results are correspondingly defective.
He knew that the defences of that_ place were defective, and that if the fleet were destroyed whilst that of Togo kept the sea, there would be no Russian offensive.
The statistics of communicants or members are defective, and because of the different organization in this respect of different bcdies, notably of the Protestants and Roman Catholics, comparisons are more or less misleading.Advertisement
A much less wise class than the 7r-computers of modern times are the pseudo-circle-squarers, or circle-squarers technically so called, that is to say, persons who, having obtained by illegitimate means a Euclidean construction for the quadrature or a finitely expressible value for 7r, insist on using faulty reasoning and defective mathematics to establish their assertions.
Judged by modern standards, his description of the direction of rivers and mountain-chains seems defective, but allowance must be made for difficulties in procuring information, and for want of accurate instruments.
The public schools of Rio de Janeiro are defective both in organization and administration; the non-attendance of children from the higher classes, and the antagonism of the Church to schools under purely secular administration, must be held responsible for the backwardness of these schools.
The natural causes of famine are still mainly outside our control, though science enables agriculturists to combat them more successfully, and the improvement in means of transport allows a rich harvest in one land to supplement the defective Breaking up of totemism.
Entering the church he found the preacher engaged in expounding the words, "We have also a more sure word of prophecy," from which the ordinary Protestant doctrine of the supreme authority of Scripture was being enforced in a manner which appeared to Fox so defective or erroneous as to call for his immediate and most energetic protest.Advertisement
But it was defective in quantity.
At Herrnhut there were conflicting tendencies, doctrinal and practical extravagances, and the organization of the brethren was very defective.
Few states have done so much as Pennsylvania for the humane and scientific treatment of its dependent and defective classes.
In cases where such an explanation is precluded by the nature of the details foreshadowed, the evidence is found to be defective, generally from the absence of contemporary documents.
Educated privately, he entered the artillery in Cologne, but defective eyesight compelled him to leave the army.Advertisement
The gardener aims usually at producing stout, robust, short-jointed stems, instead of long lanky growths defective in woody tissue.
It must be further remarked that both the " dunepans," or depressions, which are naturally marshy through their defective drainage, and the geest grounds - that is, the grounds along the foot of the downs - have been in various places either planted with wood or turned into arable and pasture land; while the numerous springs at the base of the dunes are of the utmost value to the great cities situated on the marshy soil inland, the example set by Amsterdam in 1853 in supplying itself with this water having been readily followed by Leiden, the Hague, Flushing, &c.
It will be of service, however, to attempt a summary of his treatment under these several heads, - the more so as almost all expositions of his philosophy are entirely defective in the account given of this essential portion.
Defective, however, as they may have been, and unfounded in fact, his kabbalistic doctrines led him to trace the dependence of the human body upon outer nature for its sustenance and cure.
Many such have been made, and they may be found in chemical text-books of high authority, but they are defective because of the lack of commercial knowledge in association with the chemical skill.Advertisement
The ancient system seems simple enough; but in order really to flood the whole Nile Valley during seasons of defective as well as favourable floods, a system of regulating sluices, culverts and syphons is necessary; and for want of such a system it was found, in the feeble flood of 1888, that there was an area of 260,000 acres over which the water never flowed.
The rest has been accomplished by dogmatic prejudice, which is quite capable of working other miracles besides turning a defective literary production into an unrivalled masterpiece in the eyes of believers.
In Mahomet's case this is the less wonderful because he was indebted to the instruction of Jews and Christians, whose Arabic - as the Koran pretty clearly intimates with regard to one of them - was very defective.
The earlier merciless practice had been in theory abolished by a decree based on the German system, published in 1880; but owing to defective organization, and internal disturbances induced by Khedive Ismails follies, the law had not been applied, and the 6000 recruits collected at Cairo in January 1883 represented the biggest and strongest peasants who could not purchase exemption by bribing the officials concerned.
The Sudanese, moreover, shoot better than the fellahin, whose eyesight is often defective.Advertisement
The maps of Ecuador, which are very defective, usually describe its territory as extending eastward to the Brazilian frontier, but as Peru is in actual occupation of the region east of Huiririma-chico, on the Napo river, 31 degrees west of that frontier, those maps cannot be considered correct.
When these devices failed, attempts were made unsuccessfully to exclude Lord Stewart from the conferences on the ground of defective powers.
But this form disappears with the decease of Greek national life, and on its collapse follows the romantic, the third form of art; where the harmony of form and content again grows defective, because the object of Christian art - the infinite spirit - is a theme too high for art.
Man's primary religious feeling seeks to bring him into association with the events and persons of his race, and that which in the Old Testament appears most perishable, most defective, and which suffers most under critical inquiry, was necessary in order to adapt new teaching to the commonly accepted beliefs of a bygone and primitive people.'
The projecting rods of bronze were then cut away, and the whole finished by rubbing down and polishing over any roughness or defective places.Advertisement
Both the Dorpat and the Pulkovo refractors are defective in rigidity, especially in right ascension.
The slow motion in right ascension is defective, being accomplished in the Dorpat refractor by changing the.
In 1792 Jay consented to stand for the governorship of New York State, but a partisan returningboard found the returns of three counties technically defective, and though Jay had received an actual majority of votes, his opponent, George Clinton, was declared elected.
The immediate cause of collapse seems to have been cold, due to the deficiency of oil fuel in the Mount Hooper depot, the reason for which was stated to be evaporation through defective stoppers.
Much has been made of his defective accounts of the tyrants and the Macedonian empire, and his opinion that Greek history ceased to be interesting or instructive after Chaeronea.Advertisement
The supposed triple order - conception, judgment, reasoning - is defective and false.
They found that the germ of tetanus had been introduced into the fluid before the bottle was opened at Malkowal, and they thought it probable that this might have occurred owing either to insufficient sterilization or to the process of filling the bottle from a larger flask having been performed with defective precautions.
Valladolid and Madrid; but in many parts of the province the means of communication are defective.
But from the dynamical standpoint it is obvious that equations which represent the facts correctly on one system of time-measurement might become seriously defective on another.
But that classification is founded on the absolute instead of the comparative motions of the pieces, and is, for that reason, defective, as Willis pointed out in his admirable treatise On the Principles of Mechanism.
It would seem, therefore, that after the manuscript was finished the " marginal scholia " were discovered to be extremely defective, and a new series of extracts was added in a form which interfered as little as possible with the appearance of the book.'
Yet even the most defective poems commonly have, at least, a single verse, expressing some profound thought or tender shade of feeling, for which the sympathetic reader willingly pardons artistic imperfections in the rest.
His education was only elementary and very defective, except in mathematics, in which he was largely self-taught; and although at his death he left a considerable library, he was never an assiduous reader.
The plate was now carefully heated over charcoal fire, fresh amalgam being added, as the powder fused, upon any defective places.
In 441 a synod of sixteen bishops was held at Orange under the presidency of St Hilary of Arles, which adopted thirty canons touching the reconciliation of penitents and heretics; the ecclesiastical right of asylum, diocesan prerogatives of bishops, spiritual privileges of the defective or demoniac, the deportment of catechumens at worship, and clerical celibacy (forbidding married men to be ordained as deacons, and digamists to be advanced beyond the sub-diaconate).
The grouping into classes and the privilege of exchanging property, granted to the contributor against any one whom he believed entitled to take his place, are marks of the defective economic and financial organization of the age.
Hence the cause of the shock and spark when the jar is discharged, or when the superabundant or plus electricity of the inside is transferred by a conducting body to the defective or minus electricity of the outside.
There will still be room for the scientific use of the imagination and for the creative flashes of genius.3 If, then, Bacon himself made no contributions to science, if no discovery can be shown to be due to the use of his rules, if his method be logically defective, and the problem to which it was applied one from its nature incapable of adequate solution, it may not unreasonably be asked, How has he come to be looked upon as the great leader in the reformation of modern science?
Irregular and defective deposits are therefore obtained.
The regular "man-eater" is generally an old tiger whose vigour is past, and whose teeth are worn and defective; it takes up its abode in the neighbourhood of a village, the population of which it finds an easier prey than wild animals.
This tenacity of the Saga stands in the sharpest contrast with the fact that the historical memory of the Persian is extremely defective.
This event brings us to one of the most interesting periods of Persian history, any account of which must be defective without a prefatory sketch of Ismail Sufi.
Imperfect digestion is very often caused by defective teeth or by undue haste in eating, so that the food is bolted instead of being sufficiently masticated and insalivated.
Deficient nervous action also leads to defective secretion and movement in the intestine, sometimes with flatulent accumula tion and sometimes with constipation.
Communication with the interior is only by roads, which are extremely defective, and nearly all the traffic is by pack animals.
Butler's moral theory, like those of his English contemporaries and successors, is defective from not perceiving that the notion of duty can have real significance only when connected with the will or practical reason, and that only in reason which wills itself have we a principle capable of development into an ethical system.
Ausonius was rather a man of letters than a poet; his wide reading supplied him with material for a great variety of subjects, but his works exhibit no traces of a true poetic spirit; even his versification, though ingenious, is frequently defective.
As regards profane history his materials were exceedingly defective.
The great drawback to this region is defective drainage; the streams have too sluggish a current to carry off the water in the rainy season.
They fill slight depressions and are caused by defective drainage.
In particular he maintained that the constant pressure K, which occurs in Laplace's theory, and which on that theory is very large, must be in point of fact very small, but the equation of equilibrium from which he concluded this is itself defective.
The actual strengths of the two Turkish armies, owing to inexact and defective returns, cannot be stated.
As the result, we get from Livy very defective accounts even of the Italic peoples most closely connected with Rome.
The History is defective in its lack of objectivity; Graetz's judgments are sometimes biassed, and in particular he lacks sympathy with mysticism.
On the morning of the 29th of September 1902 Zola was found dead in the bedroom of his Paris house, having been accidentally asphyxiated by the fumes from a defective flue.
The steam engine weighed about 7 lb per horse-power, but the equilibrium of the apparatus 'was defective.
If the nuisance arises from the absence or defective construction of any structural convenience, or if there is no occupier of the premises, the notice must be served upon the owner.
Bellarmine, whose life was a model of Christian virtue, is the greatest of modern Roman Catholic controversialists, but the value of his theological works is seriously impaired by a very defective exegesis and a too frequent use of "forced" conclusions.
But when they pass beyond this narrow sphere, as particularly in the Gathas, the Pahlavi translator becomes a defective and unreliable interpreter.
The merit of achieving this belongs to the enthusiastic orientalist Anquetil Duperron, the fruit of whose prolonged stay in India (1755-1761) and his acquaintance with the Parsee priests was a translation (certainly very defective) of the Zend-Avesta.
As a general argument his account of the determination of the will is defective, notably in his abstract conception of the will and in his inadequate, but suggestive, treatment of causation, in regard to which he anticipates in important respects the doctrine of Hume.
On the 22nd of May the battle of Kalpi was won, though the European troops were hampered by defective ammunition and Sir Hugh himself here received his fifth sunstroke.
The estimate aggregate for three and a half centuries is certainly large, but the exact amount will probably never be known, because the returns in colonial times were as defective as those of disorderly independence have been.
But before this was accomplished the filtration of the effluent became defective, and brackish water was received, which rapidly increased nearly to the saltness of the inflow.
In addition to defects arising out of the condition or figure of the rock or of artificial work upon which the puddle clay rests, the puddle wall itself is often defective.
We have hitherto considered only the horizontal overturning pressure of the water; but if from originally defective construction, or from the absence of vertical pressure due to weight of masonry towards the water edge of any horizontal bed, as at ab in fig.
No person not of full age, imperfectly educated, stupid, blind, deaf, deformed or otherwise defective in mind or body, or for any reason whatsoever unfit to discharge the duties or unworthy to represent the manhood of the nation, could be king, even though he were the eldest son of the preceding king.
First, if the three intersections by the line infinity are all distinct, we have the hyperbolas; if the points are real, the redundant hyperbolas, with three hyperbolic branches; but if only one of them is real, the defective hyperbolas, with one hyperbolic branch.
This work is in parts defective; Martin's descriptions of the Gauls are based rather on romance than on history, and in this respect he was too much under the influence of Jean Reynaud and his cosmogonic philosophy.
No examples of this bird seem to have been brought to Europe before the beginning of the present century, and accordingly the descriptions previously given of it by systematic writers were taken at second hand and were mostly defective if not misleading.
The Greek commentaries ascribed to Ulpian are especially defective on the historical side, and give little essential aid.
Not that it is wholly free from error or exaggeration, but its mistakes are due merely to defective knowledge of the outside world, and its overstatements, virtually confined to the matter of numbers, proceed from a patriotic desire to magnify Jewish victories.
Lord Rayleigh has pointed out that all theories are defective in that they disregard the fact that one at least of the media is dispersive, and that it is probable that finite reflection would result at the interface of media of different dispersive powers, even in the case of waves for which the refractive indices are absolutely the same.
He soon retired from the public service; he conceived a great distaste for it, and had shown himself defective in discipline and regularity.
The defective formation of the pony, the perpendicular shoulder and the drooping hind quarters, are modified; but neither the latter, nor bent hocks, which place the hind legs under the body as in the zebra, are objected to, as the conformation is favourable to rapid turning.
It was only late in life that he learnt to read and write, and his Latin was always very defective.
There are electric tramways and a good water-supply, but most of the older houses are fragile wooden structures coated with lime or mud, and the sanitation is defective.
The latter's son, Prince Rupert, became heir to the throne but he was mentally defective.
The strain of Aspergillus flavus used to reduced aflatoxin in cotton has been found to be defective in aflatoxin synthesis  .
The change in color was accompanied by a buildup of defective protein aggregates inside the cells.
On 8 March Dudley wrote off the maintenance arrears which had accrued under the defective IMA.
The mice also showed symptoms of defective muscular coordination called ataxia, which has been linked to oxidative stress.
Product Liability Product Liability is your legal liability to pay damages consequent upon a defective product being used in the contract.
Antifreeze stains here indicates that the internal seal which keeps coolant away from the bearing is defective.
The works involved excavations in Leicester Road to lay a large 1000 mm x 650 mm elliptical culvert to replace the existing defective culvert.
In 1912 part of the school was used for " mentally defective " children The Infant School staff, 1895.
Equally disturbing was the fact that people are willing to take to the roads without a valid driving license or seriously defective vehicles.
Ceilings Upgrading or renewal of old lath and plaster ceilings or otherwise defective ceilings to provide adequate fire resistance.
I think this is outrageous, as the product is clearly defective if it stops working after 14 months careful use.
As our stockpile weapons age we expect more parts to become defective - just as with our automobiles.
The unit is returned promptly on being found defective.
No refunds can be processed if returning goods for this reason until the item has been evaluated and deemed defective by the manufacturer.
In both cases he found they had defective eyesight which assured them repatriation.
But the Y has no sexual ' partner ' with which to swap out defective genes.
This oil was escaping through a defective oil interceptor to the river nearby.
The problem was traced to a defective gene which should have made a substance called monoamine oxidase.
This means that a person injured by a defective product can sue for damages without having to prove a producer negligent.
Defective viral DNA ameliorates symptoms of geminivirus infection in transgenic plants.
Any damaged or defective items would be replaced without charge and the cost of return postage refunded.
In addition to reducing the incidence of flooding, there will also be fewer disruptions arising from emergency repairs to defective sewers.
Our warranty covers against defective workmanship only, misuse or wilful damage will render the warranty void.
That there are defects in the logical process as here outlined to account for the curious rite constitutes no valid objection to the theory advanced, for, in the first place, primitive logic in matters of belief is inherently defective and even contradictory, and, secondly, the strong desire to pierce the mysterious future, forming an impelling factor in all religions - even in the most advanced of our own day - would tend to obscure the weakness of any theory developed to explain a rite which represents merely one endeavour among many to divine the intention and plans of the gods, upon the knowledge of which so much of man's happiness and welfare depended.
Weisse; but, whereas Weisse thought that the Hegelian structure was sound in the main, and that its imperfections might be mended, Fichte held it to be incurably defective, and spoke of it as a "masterpiece of erroneous consistency or consistent error."
On the other hand carelessness and neglect were severely punished, as in the case of the unskilful physician, if it led to loss of life or limb his hands were cut off, a slave had to be replaced, the loss of his eye paid for to half his value; a veterinary surgeon who caused the death of an ox or ass paid quarter value; a builder, whose careless workmanship caused death, lost his life or paid for it by the death of his child, replaced slave or goods, and in any case had to rebuild the house or make good any damages due to defective building and repair the defect as well.
The one disadvantage of paper cables is the fact that any injury to the lead covering which allows moisture to penetrate causes telegraphic interruption to the whole of the enclosed wires, whereas if the wires are each individually coated with gutta-percha, the presence of moisture can only affect those wires whose covering is defective There is no reason for doubting, however, that, provided the lead covering remains intact, the paper insulation is imperishable; this is not the case with gutta-percha-covered wires.
Its sanitary condition, though still defective, was improved by the drainage of the adjacent Almajar Marsh; and after 1870, when the population had dwindled to about 26,000, Cartagena advanced rapidly in size and wealth.
Nevertheless, many schools are still defective, both from a hygienic and a teaching point of view; while the economic position of the elementary teachers, who in Italy depend upon the communal administrations and not upon the state, is still in many parts of the country extremely low.
But at the same time many of the shortcomings of oology in this respect must be set down to the defective information and observation of its votaries, among whom some have been very lax, not to say incautious, in not ascertaining on due evidence the parentage of their specimens, and the author next to be named is open to this charge.
The improper use of engraving is to hide defective material.
It was, however, far easier to acknowledge that the Capitulations rgime was defective and had outlived its time than to devise a remedy and get all the nations interested to accept it.
Most bad habits and stable tricks are the result of defective management and avoidable accidents.
Many of the detached incidents and facts of our daily life pass around and over her unobserved; but she has enough detailed acquaintance with the world to keep her view of it from being essentially defective.
It's very important that you do this before buying, for you don't want to get home only to discover that you have a defective product.
Contact the customer service center at your online rental store, report the problem and send back the defective DVD for a replacement.
The GPS Store has a 30-day return policy for new, unopened items as well as defective equipment you would like to exchange.
This distributor also has a liberal return policy for defective bowling balls.
If you find that you need to replace a defective part, call the customer service number provided on the registration card or appliance manual.
Most manufacturers will provide you with excellent customer service and promptly send you the necessary replacement parts or advise you on how to return a defective appliance.
These stores also might have defective rugs and curtains that are significantly discounted.
Sometimes a manufacturer creates a product that is slightly defective.
Since the heating coils will be installed beneath your floor, make sure to invest in quality materials; ripping up a floor to replace a defective pipe or mat will be more costly than top quality materials will be.
Defective safety equipment can't provide effective eye protection.
Some of these shops purchase defective merchandise to sell at a discount.
The warranty covers defective materials or workmanship but not normal wear and tear.
That said, Sunglass Giant is an authorized seller of Mauis so the odds are very good that the process of fixing your defective pair will be quite similar to the one you'd find on the Maui site.
Once you buy merchandise that is counterfeit, you'll have no way of getting your money back should that merchandise be defective in any way.
To be clear, the chances are good that it/they will be defective.
Be sure to ask questions about what that includes-scratches, breakage, defective frames only, and so forth.
If you do love them, but they break as a result of defective craftsmanship or materials, you have a two-year warranty to fall back on.
The company finally issued a recall for Bubble Bobble four months later, replacing defective cartridges if shipped in their pre-paid envelopes with an original receipt.
If there is a problem with the tracks, just replace the one section that's defective, it will save you on costs.
It is important to make sure that you are not getting defective merchandise when you purchase it, but how do you know when you are getting a great deal or inferior equipment?
Refunds are given on defective merchandise.
Depending on the nature of the problem, the recall may require you to send in the defective cell phone directly to Samsung or to your chosen wireless carrier.
These include defective heart valves, hypertrophic cardiomyopathy (enlarged heart muscle), holes or abnormal openings in the walls of the heart (septal defects), aortic aneurysm, or other congenital heart disease.
Both forms of neurofibromatosis are caused by a defective gene.
Both of these disorders are inherited in a dominant fashion, which means that anyone who receives just one defective gene will have the disease.
In some genetic diseases, a person needs to have two copies of a defective gene in order to show symptoms of the disease; if only one of the two genes is defective, the person is considered a carrier.
In autosomal recessive inheritance, the affected individual has inherited a defective gene from each parent.
If a defective gene encoding for a disease is found on the X chromosome, then a male child cannot have a healthy copy of the gene (since he only has one X chromosome); therefore, he will develop the disorder.
Female children are at less risk because they have to have two copies of the defective gene (one on each X chromosome) in order to develop the disease.
As opposed to autosomal recessive inheritance, only one defective copy of a gene needs to be inherited in order for an individual to develop the disease.
The defective gene tells the body to make the abnormal hemoglobin HbS instead of the normal HbA, and this results in deformed red blood cells.
In Marfan's syndrome, the gene responsible for fibrillin has mutated, causing the body to produce a defective protein.
The gene that, when defective, causes CF is called the CFTR gene, which stands for cystic fibrosis transmembrane conductance regulator.
However, 70 percent of all people with a defective CFTR gene have the same defect, known as delta-F508.
There is no known way to prevent development of CF in a person with two defective gene copies.
Cystic fibrosis results when a person has two defective copies of the CFTR gene.
Albinism is a autosomal recessive disease, which means that a person must have two copies of the defective gene to exhibit symptoms of the disease.
The child therefore inherits one defective gene responsible for making melanin from each parents.
About one in 70 people are albinism carriers, with one defective gene but no symptoms; they have a 50 percent chance of passing the albinism gene to their child.
However, if both parents are carriers with one defective gene each, they have a one in four chance of passing on both copies of the defective gene to the child, who will have albinism.
There is also a type of ocular albinism that is carried on the X chromosome and occurs almost exclusively in males because they have only one X chromosome and, therefore, no other gene for the trait to override the defective one.
Genetic testing can be used, in some cases, to identify the defective gene.
This condition has an X-linked, recessive pattern of inheritance, meaning that the defective gene is carried on the X chromosome.
A female who carries a defective recessive gene on one of her two X chromosomes will not have the disease because she also has one good X chromosome.
However, she has a 50 percent chance of passing the defective gene to her sons.
The sons inheriting one defective gene will develop the disorder because a male has only one X chromosome, which he receives from his mother and one Y chromosome from his father.
The mother also has a 50 percent chance of passing the defective recessive gene to her daughters who will be carriers of the disorder (like their mother), but will not show symptoms of the disease.
Women who are carriers of the defective gene can also be identified by a blood test.
Gaucher disease has a recessive pattern of inheritance, meaning that a person must inherit a copy of the defective gene from both parents in order to have symptoms of the disease.
The defective gene that causes this disorder is found in roughly one in 250 people in the general population.
An individual displaying a recessive trait must have inherited one copy of the defective gene from each parent.
A person with only one defective gene copy will not show signs of FA, but may pass along the gene to offspring.
There is no way to prevent development of FA in a person carrying two defective gene copies.
A-T is a recessive disorder, meaning that it affects children who carry two copies of a defective (mutated) A-T gene, one copy from each parent.
An estimated 1 percent (2.5 million) of the general population carries one of the defective A-T genes.
Variations that cause disease are called mutations and A-T results from a defective gene, the ATM gene (for ataxia telangiectasia, mutated), first identified in 1995.
Turner syndrome is a chromosomal abnormality occurring only in females in whom one of the X chromosomes is missing or defective.
In children with SCID, the immune system does not function properly because T, B, and NK cells are either absent or defective.
Muscles that receive defective messages from the brain may be constantly contracted and tight (spastic), exhibit involuntary writhing movements (athetosis), or have difficulty with voluntary movement (dyskinesia).
If the parent has one good copy of the gene and one defective copy, the parent will not have MPS and may be unaware that he or she has a defective gene.
He will have the disorder if the X chromosome inherited from his mother carries the defective gene, since he has only one (nonfunctioning) copy of the gene.
Additionally, there is ongoing research involving gene replacement therapy (the insertion of normal copies of a gene into the cells of patients whose gene copies are defective), although this was as of 2004 still highly experimental.
For some of the MPS diseases, biochemical tests may be able to identify healthy individuals who are carriers of the defective gene, allowing them to make informed reproductive decisions.
Tuberous sclerosis occurs when at least one of two genes (either TSC-1 on chromosome 9 or TSC-2 on chromosome 16) is defective.
When the TS genes are defective or absent, the proteins are either absent or deficient, which allows tumor growth.
This means that the disease does not occur due to the inheritance of an abnormal gene, but rather because the baby's gene is defective for some reason other than inheritance.
Tay-Sachs is caused by a defective gene.
Because Tay-Sachs is a recessive disorder, only people who receive two defective genes (one from the mother and one from the father) will actually have the disease.
People who have only one defective gene and one normal gene are called carriers.
They carry the defective gene and thus the possibility of passing the gene and/or the disease onto their offspring.
When two carriers have children, their children have a 25 percent chance of having normal genes, a 50 percent chance of being carriers of the defective gene, and a 25 percent chance of having two defective genes.
Only the individual with two defective genes actually has the disease.
When the levels of hexosaminidase A are half the normal level, a person is a carrier of the defective gene.
However, a glitch in the biosynthesis pathway-represented by a defective enzyme-means that heme biosynthesis does not reach completion.
In autosomal recessively inherited disorders, a child must inherit two defective genes, one from each parent.
The underlying cause of all porphyrias is a defective enzyme important to the heme biosynthesis pathway.
Making this determination yields a strong indicator of which enzyme in the heme biosynthesis pathway is defective; which, in turn, allows a diagnosis of the particular type of porphyria.
Certain enzymes, such as porphobilinogen deaminase (the defective enzyme in AIP), can be easily extracted from red blood cells; other enzymes, however, are less readily collected or tested.
The parent with the defective gene has the disease, and each of this parent's children has a 50 percent chance of inheriting the disease.
However, for a child to have one type of myotonia congenita and some forms of nemaline myopathy, two defective genes must be inherited-one from each parents.
Neither parent may have symptoms of the disease, but each carries a recessive defective gene for it.
Each child of such parents has a 25 percent chance of inheriting both genes and showing signs of the disease, and a 50 percent chance of inheriting one defective gene from only one parent.
If the child has inherited just one defective gene, he or she will be a carrier of the disease and can pass the gene on to his or her offspring, while showing no signs of the disease himself.
Females who inherit the defective gene are usually carriers without symptoms, like their mothers, but they can pass on the disease to their sons.
This means that both parents need to be carriers of the defective gene in order for a child to develop the disease.
Sickle cell anemia is an inherited, chronic, incurable blood disorder that causes the body to produce defective hemoglobin, the abnormal HgbS, which occurs primarily in African Americans.
Individuals with hemoglobin H disease have inherited one completely defective gene and one gene that has one rather than two functional loci.
Individuals with alpha thalassemia major have inherited two completely defective genes, one from each parent.
Beta thalassemia minor describes a disease where only one gene of the pair that control beta hemoglobin production is defective.
If parents are thinking of having a child and believe they might be carriers of defective hemoglobin genes, they can be screened and receive genetic counseling so that they can assess their options.
It represents a defective or decreased production of platelets.
Common underlying disorders include leukemia, drug toxicity, or aplastic anemia, all of which lead to decreased or defective production of platelets in the bone marrow.
This means that possession of only one copy of the defective gene is enough to cause disease.
Females who carry the defective gene have a 50 percent chance of passing it on to their sons but are not affected themselves by the disorder.
The daughters of carriers have a 50 percent risk of carrying the defective gene to the next generation.
The diagnosis of hyper-IgM syndrome can be confirmed by molecular genetics testing for the defective CD40 gene.
Genetic counselors recommend having the affected child's siblings tested to see whether they are carriers of the defective gene.
The goal of the treatment is to promote the growth of the injected cells, replacing the defective host cells with healthy new ones.
Immunodeficiency disorders are a group of disorders in which part of the immune system is missing or defective.
Females can have the defective gene, but since they have two X chromosomes, there will be a normal gene on the other X chromosome to counter it.
Women may pass the defective gene on to their sons.
For example, severe combined immunodeficiency disease (SCID) is caused by the defective development or function of these two types of lymphocytes.
Sometimes a person may have normal cell counts, but the cells are structurally defective.
If Btk is missing or defective, the B cells cannot mature and cannot produce immunoglobulins.
This means that for boys to have XLA they must only inherit one copy of the defective gene, but for girls to have the disease they have to inherit two copies, one from each parent.
Similar analysis can be used for prenatal diagnosis or to detect carriers of the defective gene.
This form of spinal muscular atrophy only affects men; it is an X-linked recessive disorder, meaning that the defective gene is passed from mother to son.
It results from a child inheriting defective genes from both parents (autosomal recessive pattern of inheritance).
The chance that two parents each of whom has the defective gene will produce a child with a recessive disorder is one in four or 25 percent with each pregnancy.
For all types of MEN, the children of an affected individual have a 50 percent chance of inheriting the defective gene that causes the disorder.
When both copies are defective, tumor suppression fails and tumors develop.
Before the development of genetic testing, there was no way to definitively identify which children had inherited the defective gene.
Molecular techniques as of the early 2000s allow a positive distinction to be made between children who are and are not carrying the defective genes that cause MEN.
Carrier females also have a 50 percent risk of passing the defective copy of the gene to their daughters who also become carriers.
Information about the exact mutation and the quantity of WAS protein the defective gene can produce may help predict the severity of the individual's condition.
Although there are no available treatments to prevent the development of WAS in an individual who receives the defective gene, prenatal genetic counseling can help couples determine their risk of having a baby with WAS.
The primary problem for children who survive with DiGeorge syndrome is repeated infections due to a defective immune system.
DiGeorge syndrome is caused either by inheritance of a defective chromosome 22 or by a new defect in chromosome 22 in the fetus.
The child is born with a defective immune system and an abnormally low level of calcium in the blood.
Because the immune system of a child with DiGeorge syndrome is defective, a doctor should be consulted at any signs of illness or disease.
The child is also born with a defective immune system and an abnormally low level of calcium in the blood.
When this defective cell is involved in the conception of a baby, that baby will have a total of 47 chromosomes.
Pregnancy tests undergo strict quality control procedures, so a defective test is rare.
The restaurant was repaired, but in 1894 it was partially destroyed again due to a defective fluke.
Both parent must carry and pass on the defective gene for a baby to have PKU.
The warranty includes in-house service and repair, as well as product replacement if the product is proved defective.
The warranty excludes gaskets, knobs, valves and pumps, unless the consumer proves these pieces were defective at purchase.
This warranty covers products that are defective out of the box and products that break down within the first year due to a manufacturer defect.
The warranty covers the repair or replacement of the defective product.
Shopping during extreme discount days can mean that merchandise is harder to return if it is defective, so check return policies at all stores before leaving.
One possible method of weeding out defective individuals is to prolong your email and phone correspondences and delay a face-to-face meeting.
Even so, this reviewer is convinced that he or she just happened to receive a bag with a defective zipper.
If you think they're falling apart long before they should be, or they have a defective part, they will definitely check them out for you.
The Mermelstein family stands behind the Diamond Ingot Gold Croton Watch, offering a lifetime warranty covering malfunctions as a result of defective materials or workmanship.
Try a recycled cartridge, but make sure you can return it if it is defective.
Mr. Vigil also explained that if you have a defective new vehicle, the dealer works with the manufacturer to repair it or replace it.
If you feel you have a defective vehicle, the dealership's responsibility is to work with the manufacturer and the customer to repair the vehicle.
Keep a record of all repairs performed on your vehicle if you feel it is defective to help you apply for any new car return laws your state enforces.
Some 1995 models had defective battery issues with a potential for explosion, and 1997 models had airbag systems that were so touchy that any slight shock to the system could set off an accidental airbag deployment.
In 1998 and 1999, a few Corollas required replacement lug nuts because some were defective and there was a danger that some cars could potentially lose a wheel.
From 2005 through 2008, Toyota Corollas suffered from defective engine control modules on the cars with certain engines.
These companies may replace or repair the electronic device that was damaged by defective batteries.
Common problems include chains and bolts that come loose and defective computer read-outs.
Others have lemon laws that protect consumers from defective purchases.
A Panasonic camcorders warranty is meant to provide coverage in the event of defective equipment, and is not necessarily meant as an insurance policy to protect against future damage.
Every retailer has their own return policy, so customers who find themselves with broken camcorders may be able to return the defective equipment to the place where they bought it and receive a new camcorder.
In fact, if a person finds a broken or defective Craftsman tool, Sears will repair or replace the tool if they bring it into any store where Craftsman tools are sold.
The federal government has several studies underway to evaluate the size and impact of the seemingly defective drywall.
The damage caused by the defective drywall has caused homeowners to start filing claims on their homeowners insurance.
Some homeowners face the decision of whether to file the claim and hope for a settlement to pay for replacement of the defective drywall.
Unfortunately there are no quick fixes and there does not seem to be any immediate financial relief for the homeowners who want to quickly replace their defective drywall.
Check your warranty insurance - Determine if your policy coverage includes replacement of walls, air conditioners and other appliances due to defective drywall.
In a type built with vertical sections each division is complete in itself, and is not directly connected with the next section, but communicates with flow and return drums. A defective section may thus be left in position and stopped off by means of plugs from the drums until it is convenient to fit a new one in its place.
In 1904 official estimates, based on immigration and emigration returns and upon registered births and deaths, both of which are admittedly defective, showed a population increased to 5,410,028, and a small diminution in the rate of annual increase from 1895 to 1904 as compared with 18.69-1895.
Owing to the great distances which must be covered, and also to the defective means of communication in sparsely settled districts, the costs of the postal service in Argentina are unavoidably high in relation to the receipts.
Our knowledge of the salinity of waters below the surface is as yet very defective, large areas being still unrepresented by a single observation.
Others again, like Michaelis and Rosenmiiller, have supposed that the name Cush was applied to tracts of country both in Arabia and in Africa, but the defective condition of the ancient knowledge of countries and peoples, as also the probability of early migrations of "Cushite" tribes (carrying with them their name), will account for the main facts.
He taught mathematics at Columbia, and in 1845 was admitted to the bar, but, owing to defective eyesight, never practised.
Depretis and his colleague Genala, minister of public works, experienced great difficulty in securing parliamentary sanction for the conventions, not so much on account of their defective character, as from the opposition of local interests anxious tc extort new lines from the government.
With all its defective psychology, its barren logic, its immature technique, it emphasized two great and necessary truths, firstly, the absolute responsibility of the individual as the moral unit, and, secondly, the autocracy of the will.
Milbourn (1867) the defendant had broken his contract to let a lecture-room to the plaintiff, on discovering that the intended lectures were to maintain that "the character of Christ is defective, and his teaching misleading, and that the Bible is no more inspired than any other book," and the court of exchequer held that the publication of such doctrine was blasphemy, and the contract therefore illegal.
Here, however, the buds are lateral, though produced from a budding may be defective upon one or other of the noto a b FIG.
Oldham's verse is rugged, and his rhymes often defective, but he met with a generous appreciation from Dryden, whose own satiric bent was perhaps influenced by his efforts.
With all their elaboration, these tables are, however, defective, as omitting some of the highest and most influential springs of action.
It set out also at length the very defective and disorderly condition of the state accounts.
The Christian population, who in common with their Mussul- Macedo ' 'Questio man fellow subjects suffered from the defective methods of government of their rulers, had at least before them the example of their brethren - Greeks, Bulgarians or Servians - dwelling in independent kingdoms under Christian governments on the other side of the frontier.
In modern times Tribonian has been, as the master workman of Justinian's codification and legislation, charged with three offences - bad Latinity, a defective arrangement of the legal matter in the Code and Digest, and a too free handling of the extracts from the older jurists included in the latter compilation.
Like that of other Byzantine writers, Chalcondyles' chronology is defective, and his adherence to the old Greek geographical nomenclature is a source of confusion.
The census of the 31st of December 1900 was strikingly defective; it was wholly discarded for the city of Rio de Janeiro, and had to be completed by office computations in the returns from several states.
The Museu Nacional at Rio de Janeiro, which has occupied the imperial palace of Sao Christovao since the overthrow of the monarchy, contains large collections of much scientific value, but defective organization and apathetic direction have rendered them of comparatively slight service.
It is curious that Laplace, while bestowing more attention than they deserved on the crude conjectures of Buffon, seems to have been unaware that he had been, to some extent, anticipated by Kant, who had put forward in 1755, in his Allgemeine Naturgeschichte, a true though defective nebular cosmogony.
A good deal of confusion has arisen in the discussions of this latter topic, owing to defective nomenclature.
It is definitely ascertained that many animals are thus born with distorted or defective eyes whose parents have not had their eyes submitted to any peculiar conditions.
A defective stock, if allowed to breed, will perpetuate its defects, in spite of the concealment of those defects in an individual by training or other treatment.
From the first his supply arrangements had been defective, and the requisitions made by his leading troops left nothing for the rest to eat.
Any of the abnormal conditions that bring about general or local defective nutrition is an important factor in producing fatty degeneration.
The pieces of glass are then examined for the detection of the grosser defects, and obviously defective pieces are rejected.
From the annealing kiln the slabs of glass are transported to the cutting room, where they are cut square, defective slabs being rejected or cut down to smaller sizes.
The method employed by Maclaurin has been thought not sufficiently rigorous; and that of John Bernoulli is, in the opinion of Lagrange, defective in clearness and precision.
Unfortunately, however, the confusion engendered by a defective organization has long been a byword among the people; there is no printed catalogue, quantities of books are buried in packingcases and unavailable, the collection of foreign books is very poor, hardly any new works being purchased, and the building itself is quite inadequate and far from safe; but the site of a new one has now been purchased and the plans are agreed upon, so that eventually the whole collection will be transferred to more suitable quarters.
For the chronology before the year ho of the Flight Wagidi did his best, but here, the material being defective, many of his conclusions are precarious.
The whole plan was based upon defective information and preconceived ideas; it has gone down to history as a classical example of bad generalship, and its author Weyrother, who was perhaps nothing worse than a pedant, as a charlatan.
In the centre, the defective arrangements of the allied staff had delayed the 4th column (Kolowrat), the line of march of which was crossed by Liechtenstein's cavalry moving in the opposite direction.
And when in 1890 he began to gather together the miscellaneous essays and papers written during a period of sixty years, he expressed the hope that, though " they could lay no claim to logical consistency," they might yet show " beneath the varying complexion of their thought some intelligible moral continuity," " leading in the end to a view of life more coherent and less defective than was presented at the beginning."
If the calculation be carried farther backas has been done by the seismic disaster investigation committee of Japan, a body of scientists constantly engaged in studying these phenomena under government auspices,it is found that, since the countrys history began to be written in the 8th century AD,, there have been 2006 major disturbances; but inasmuch as 1489 of these occurred before the beginning of the Tokugawa administration (early in the 17th century, and therefore in an era when methods of recording were comparatively defective), exact details are naturally lacking.
There is undoubtedly in the lower ranks of Japanese tradesmen a comparatively large fringe of persons whose standard of commercial morality is defective.
The poetry of the nation remained immovable in the ancient groove until very modern times, when, either by direct access to the originals or through the medium of very defective translations, the nation became acquainted with the masters of Occidental song.
To the specialists in sciences which were advancing rapidly and in divergent directions to results which often reacted on and transformed their initial assumptions, Spencer has often appeared too much of a philosopher and defective in specialist knowledge.
Accordingly" heresy is to be distinguished from defective stages of Christian knowledge.
Such movements of antagonism to the errors or abuses of ecclesiastical authority may be so permeated by defective conceptions and injurious influences as by their own character to deserve condemnation.
The foreign-born are more numerously represented among the criminal, defective and dependent classes than their numerical strength would justify.
The city is the seat of St James College (Roman Catholic; 1856) and of the state school for defective youth (1886).
Belize is connected by telegraph and telephone with the other chief towns of British Honduras, but there is no railway, and communication even by road is defective.
To meet the expenses entailed by his liberality and extravagance, Gregory resorted to confiscation, on the pretext of defective titles or long-standing arrearages.
Charitable and Penal Institutions.-Texas has done more than any other Southern state for the humane and scientific treatment of its dependent and defective classes.
Examined from this point of view the majority of domestic filters were found to be gravely defective, and even to be worse than useless, since unless they were frequently and thoroughly cleansed, they were liable to become favourable breeding-places for microbes.
His first edition, in 1791, was confessedly very defective; the second, in 1806, still left much to be desired.
The pioneer work of the census of 1840 in the fields of educational statistics, statistics of occupations, of defective classes and of causes of death, suffered from numerous errors and defects.
His writings are defective in virility and breadth of thought, and his tragedies display neither the insight into character nor the constructive power of a great dramatist.