Stage I involves favorable Wilms' tumor cells and is usually treated successfully with combination chemotherapy involving dactinomycin and vincristine and without abdominal radiation therapy.
Stage III tumors with favorable histology are usually treated with a combination chemotherapy with doxorubicin, dactinomycin, and vincristine along with radiation therapy to the abdomen.
Stage IV disease with a favorable histology is generally treated with combination chemotherapy with dactinomycin, doxorubicin, and vincristine.
If this type of cell is present, then patients receive combination therapy with vincristine, doxorubicin, and dactinomycin.
These effective drugs include dactinomycin, doxorubicin, vincristine, and cyclophosphamide.