How to use Chromosomal in a sentence

chromosomal
  • However, no excess chromosomal aberrations in circulating human lymphocytes have been observed in patients treated for 8 months.

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  • Overall, the COM concluded that the results from the in vitro chromosomal aberration assays were likely to represent a cytotoxic response.

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  • In addition, chromosomal deletions of up to 2kb were detected at all 14 integrations sites examined.

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  • Comparative genomic hybridization findings showed chromosomal imbalances in 9 of 12 cases of choriocarcinoma.

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  • Chromosomal instability is thought to occur in 85 per cent of all colorectal cancer cases.

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  • However, the identification of all chromosomal aberrations in a complex karyotype was often not possible from such patterns.

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  • A Japanese MFS patient was found with complex chromosomal rearrangements.

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  • Where trisomy 18 is caused by an unbalanced chromosomal translocation, chromosomal analysis should be carried out on both parents.

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  • Alternatively a gene can be selected by chromosomal location or by sequence homology using a customized BLAST search.

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  • If retardation is caused by chromosomal or other genetic disorders, it is often apparent from infancy.

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  • Down syndrome-A chromosomal disorder caused by an extra copy or a rearrangement of chromosome 21.

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  • Individuals with A-T have an increased frequency of spontaneous breaks in their chromosomes as well as an increased frequency of chromosomal rearrangements.

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  • These chromosomal abnormalities often occur close to genes that control the function of white blood cells, such as immunoglobulins and T-lymphocytes.

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  • The frequency of chromosomal breaks is increased when T-lymphocytes are exposed to x rays in the laboratory, and this sensitivity to ionizing irradiation forms the basis for a specialized A-T diagnostic test.

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  • People who have idiopathic type 1 diabetes also experience beta cell destruction, but it is due to a chromosomal abnormality or an unknown cause rather than any autoimmune process.

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  • Turner syndrome is a chromosomal abnormality occurring only in females in whom one of the X chromosomes is missing or defective.

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  • Possible causes that center on the fetus rather than the mother include chromosomal abnormalities, genetic and other syndromes that impair skeletal growth, and defects of the placenta or umbilical cord.

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  • The leading cause of infant mortality is congenital malformations, deformations and chromosomal abnormalities with a rate of 20.2 percent.

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  • Since additional congenital defects preclude prenatal surgery, amniocentesis or chorionic villi sampling (CVS) are used to check for chromosomal abnormalities in the fetus.

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  • Approximately 5 to 8 percent of individuals with retinoblastoma possess a chromosomal abnormality involving the RB1 gene that can be detected by looking at their chromosomes under the microscope.

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  • If this type of chromosomal abnormality is detected in a child, then analysis of the parents' chromosomes should be performed.

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  • If one of the parents possesses a chromosomal abnormality, then they are at higher risk for having other offspring with retinoblastoma.

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  • Usually, however, a chromosomal abnormality is not detected in a child with retinoblastoma.

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  • An amniocentesis or chorionic villus sampling can be used to obtain fetal cells which can be analyzed for the RB1 gene change/deletion or chromosomal abnormality.

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  • Children with abdominal wall defects may need additional services, especially those with omphalocele and associated chromosomal abnormalities and birth defects.

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  • At birth, the newborn's numerous malformations indicate a possible chromosomal abnormality.

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  • Trisomy 13 is confirmed by examining the infant's chromosomal pattern through karyotyping or another procedure.

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  • Because of chromosomal differences between the sexes, some genes are not present in two copies.

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  • Some of these children have other defects such as cardiac anomalies, chromosomal abnormalities, kidney and genital anomalies, and neural tube defects, such as spina bifida.

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  • Klinefelter syndrome is one of the most common chromosomal abnormalities.

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  • There is no treatment available to change chromosomal makeup.

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  • Cri du chat (a French phrase that means "cry of the cat") syndrome is a group of symptoms that result when a piece of chromosomal material is missing (deleted) from a particular region on chromosome 5.

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  • Children born with this chromosomal deletion have a characteristic mewing cat-like cry as infants that is thought to be caused by abnormal development of the larynx (organ in the throat responsible for voice production).

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  • Cri du chat is the result of a chromosome abnormality-a deleted piece of chromosomal material on chromosome 5.

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  • In approximately 10 percent of children with cri du chat, there is a hereditary chromosomal rearrangement that causes the deletion.

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  • The extent of mental retardation and other symptoms depends on the site of the chromosomal deletions, with larger deletions resulting in more serious symptoms.

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  • DiGeorge syndrome is a genetic syndrome most frequently associated with a chromosomal deletion (22q11.2).

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  • Amniocentesis may reveal trisomies or other chromosomal abnormalities.

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  • Careful chromosomal study can reveal abnormalities on chromosome 15 that are consistent with those identified in Angelman's syndrome.

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  • Of all the chromosomal abnormalities that result in spontaneous abortion or miscarriage, Turner's syndrome is the most common, accounting for about 20 percent of all miscarriages.

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  • Because the symptoms caused by the chromosomal abnormality vary somewhat from child to child, the syndrome probably occurs much more often than was previously thought.

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  • While Down syndrome is a chromosomal disorder, a baby is usually identified at birth through observation of a set of common physical characteristics.

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  • Thicker measurements correlate with the possibility of Down syndrome or other chromosomal abnormalities.

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  • Prader-Willi syndrome (PWS) is a genetic condition caused by the absence of chromosomal material from chromosome 15.

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  • The piece of chromosomal material that is deleted contains genes that must be present for normal development.

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  • In fewer than 1 percent of the cases of PWS there is a chromosomal rearrangement in the family that causes the deletion.

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  • This chromosomal rearrangement is called translocation.

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  • The most common cause is chromosomal problems or genetic abnormalities.

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  • The Baby Gender Mentor Home DNA Testing Kit determines gender by tracing the amount of active genetic fetal chromosomal DNA in a sample of your blood.

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  • This procedure enables an obstetrician to determine any chromosomal disorders or open neural tube defects, such as spina bifida, that the unborn fetus may have.

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  • Some individuals have chromosomal abnormalities that make gender identification difficult.

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  • Down syndrome is a chromosomal mutation that can be identified during pregnancy through amniocentesis.

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  • Fragile X syndrome involves chromosomal problems on the X chromosome.

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  • One possible factor is that older women are more likely to conceive babies with chromosomal abnormalities.

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  • Chromosomal abnormalities are the most common cause of first trimester miscarriage.

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  • In fact, studies indicate that more than half of all miscarriages that occur before 12 weeks can be attributed to chromosomal abnormalities.

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  • Combined with the results of other tests, an amnio can give you a good idea of any chromosomal health problems your child could be born with.

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  • Some doctors recommend amnios for any pregnant woman over the age of 35 or when either parent is known to be a carrier of a chromosomal problem.

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  • From the amniotic fluid, lab technicians can determine the sex of the baby as well as other chromosomal abnormalities that indicate a genetic defect.

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  • Most amniocentesis results will turn out normal or, in other words, the test will not detect any chromosomal irregularities and you will go away from your doctor's appointment with a sense of relief.

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  • The blood test given during the first trimester screening is for chromosomal abnormalities in the baby, including Down's Syndrome (trisomy 21), Edwards Syndrome (trisomy 18), skeletal defects, or heart defects.

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  • The amount of fluid behind the baby's neck may indicate an increased risk for a chromosomal abnormality.

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  • The results of the first trimester screening tests, combined with your age, will indicate whether your baby has a high or low risk of chromosomal abnormalities.

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  • Since the results are given as high risk or low risk of chromosomal abnormalities, it does not necessarily mean that your baby has a condition, it just means you need to do further tests.

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