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Cftr sentence examples

  • chloride conductance in airway cell line, primary human cell cultures and most importantly from cells with CFTR mutations.

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  • The disease gene is named CFTR, which stands for cystic fibrosis transmembrane conductance regulator.

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  • Molecules are able to activate chloride conductance in airway cell line, primary human cell cultures and most importantly from cells with CFTR mutations.

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  • The results were the same: Cells containing mutant CFTR proteins also formed aggregates and became brightly fluorescent.

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  • Whereas high-level expression of the gene encoding CFTR has been demonstrated in the human pancreas (Ref.

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  • Nevertheless, mouse models of CF clearly demonstrate a range of abnormal pulmonary phenotypes as a result of the Cftr mutation.

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  • Underlying molecular defect CF is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

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  • The gene that, when defective, causes CF is called the CFTR gene, which stands for cystic fibrosis transmembrane conductance regulator.

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  • There are over 500 known defects in the CFTR gene that can cause CF.

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  • However, 70 percent of all people with a defective CFTR gene have the same defect, known as delta-F508.

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  • In other words, the delta-F508 mutation is a loss of one "letter" out of thousands within the CFTR gene.

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  • As a result, the CFTR protein made from its blueprint is made incorrectly and cannot perform its function properly.

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  • The CFTR protein helps to produce mucus.

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  • The role of the CFTR protein is to allow chloride ions to exit the mucus-producing cells.

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  • In this way, the CFTR protein helps to keep mucus from becoming thick and sluggish, thus allowing the mucus to be moved steadily along the passageways to aid in cleansing.

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  • In CF, the CFTR protein cannot allow chloride ions out of the mucus-producing cells.

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  • Each person actually has two copies of each gene, including the CFTR gene, in each of their body cells.

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  • For the CFTR gene, for instance, a person may have two normal copies, or one normal and one mutated copy, or two mutated copies.

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  • A carrier will not have symptoms of CF but can pass on the mutated CFTR gene to his/her children.

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  • They have a two-in-four chance of having a child who is a carrier, and a one-in-four chance of having a child with two normal CFTR genes.

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  • Most of these people do not have the delta-F508 mutation but a different one, which presumably allows at least some of their CFTR proteins to function normally in the pancreas.

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  • The CFTR protein helps to regulate the amount of salt in sweat.

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  • The discovery of the CFTR gene in 1989 allowed the development of an accurate genetic test for CF.

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  • In this set of techniques, non-defective copies of the CFTR gene are delivered to affected cells, where they are taken up and used to create the CFTR protein.

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  • Cystic fibrosis transmembrane conductance regulator (CFTR)-The protein responsible for regulating chloride movement across cells in some tissues.

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  • Cystic fibrosis results when a person has two defective copies of the CFTR gene.

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