How to use Bone-marrow in a sentence
We previously demonstrated the selective presence of 5T2MM cells in bone marrow and spleen of diseased mice.
The healthy bone marrow reacts with remarkable rapidity to the demand for more blood cells which may be required by the organism; its reactions and variations in disease are very striking.
To replace this cellular destruction there has been a demand for reinforcements on the home centres of the polymorpho-nuclear leucocytes - the bone marrow.
In the one case they are entirely restricted to the neighbourhood of the boil or ulcer, whereas in the other there is a general infection of the body, the organisms spreading to all parts and being met with in the spleen, liver, bone-marrow, &c., and (rarely) in the peripheral circulation.
People who have aplastic anemia have bone marrow that just stops working right.Advertisement
Bone marrow invasion was shown in two of 14 patients on MR images which were confirmed by bone marrow aspirate.
A tiny sample of the marrow is then drawn (aspirated) into a syringe (a bone-marrow aspirate ).
A negative result had been reported in an adequate oral bone marrow mouse micronucleus assay.
Outcome in recipients of HLA-compatible related or unrelated bone marrow was compared to those receiving a second autograft.
In a bone marrow biopsy, a slightly larger needle is used.Advertisement
Types of test There are two main types of bone marrow test - a bone marrow aspiration and a bone marrow trephine biopsy.
Briefly, target molecules will be used on bone marrow stem cells in tissue culture to induce specific appropriate differentiation.
He concluded, and we agree, that that can best be done by raising awareness of bone marrow donation.
We must not lose sight of the fact, however, that there are not enough bone marrow donors, full stop.
All of them are derived from the bone marrow but T cells undergo a process of maturation in the thymus gland.Advertisement
Josh Eaton's Home Page A 7 year old who has had a bone marrow transplant for Philadelphia chromosome positive acute lymphoblastic leukemia.
Blood donors can also add their name to the NBS's own Bone Marrow Register - and become a lifesaver twice over this holiday.
Happily, his brother Neil donated bone marrow for Lee, which was a perfect match.
During a transplant, healthy bone marrow will be fed into your blood stream.
With my first taste of roast bone marrow with parsley salad was born my enduring love of meat, nose to tail.Advertisement
Until recently there has been little consideration as to whether artifactual positive results can also be obtained in the in-vivo bone marrow assays.
Graft Versus Host A term used in donor bone marrow transplant.
The effect of the alkaloid was also tested in an in vivo assay using BALB/c mouse bone marrow cells.
Erythropoietin is a genetically engineered preparation of the human hormone that promotes maturation of red cells in the bone marrow.
Rarely, inactivation of vitamin B12 may occur which can then interfere with folate metabolism which can result in bone marrow changes.Advertisement
In myeloma, bortezomib affects the ability of myeloma cells to interact with the bone marrow microenvironment.
The Committee considered the new in vivo rat bone-marrow micronucleus test.
In the first instance this should be in the in-vivo bone marrow micronucleus assay.
Investigation showed the retroviral vector used to load a gene into bone marrow cells had inadvertently carried its DNA into a known oncogene.
Complement factor is released encouraging polymorphonuclear leukocyte release from bone marrow promoting phagocytosis, which produces heat.Advertisement
For patients with bone marrow failure, it has been accepted practice to transfuse platelets where levels are very low.
We have been investigating the chemoattractants involved in releasing mast cell progenitors from the bone marrow and mediating their recruitment to tissues.
Young patients with negative serology for CMV, who may be candidates for bone marrow transplantation, should receive CMV negative blood products.
In the remaining cases there is evidence of exposure to some factor which is known to cause damage to bone marrow stem cells.
They include the thymus, the bone marrow and the lymph nodes (see ' lymphatic system ' ).Advertisement
More than 100 printer toner cartridges are recycled each month by the Anthony Nolan Bone Marrow Trust.
She needed large amounts of blood before receiving a life-saving bone marrow transplant, donated by her brother.
What can go wrong There are up to 2,000 patients waiting for a bone marrow transplant at any given time.
For a bone marrow trephine, the needle is thicker.
Bone marrow could be reconstituted from cultured brain, and glial and neurons cells were obtained from bone marrow.Advertisement
New red cells are of course continually manufactured and this also takes place within the bone marrow.
Bone Marrow or stem cell transplants become necessary when the bone marrow becomes diseased or damaged, preventing it from functioning normally.
They include the thymus, the bone marrow and the lymph nodes (see ' lymphatic system ').
Heterosexuals at risk of transmissible diseases are also excluded from giving bone marrow.
It affects the lymph nodes, bone marrow and the intestines.Advertisement
In this stage, the animal will have infections of bone marrow and other tissue and will be considered terminally infected.
Cats in the secondary stage will often suffer repeated bone marrow infections and weakened immunity that will make them more susceptible to external and internal pathogens.
Medical help-While you might not be able to provide a cure for your child or someone else's child, you can help through blood and bone marrow donations.
The company includes bones in the Four-Star Nutritionals Chicken Thighs canned food because of the nutritional value of bone marrow and cartilage for joint health.
This strain infects the bloodstream and attacks the lining of the digestive tract, bone marrow and cells.Advertisement
A bone marrow biopsy may be done to determine what type of cells is present in the bone marrow.
Healthy bone marrow tissue constantly replenishes the blood supply and is essential to life.
Sometimes drugs or radiation needed to destroy cancer cells also destroys bone marrow and only replacement with healthy cells counteracts this adverse effect.
A bone marrow transplant involves removing marrow from a donor and transplanting blood-forming cells to a recipient.
While not a therapy in itself, bone marrow transplantation may allow a cancer patient to undergo aggressive therapy.
Hematologists specialize in disorders of the blood and bone marrow and are consulted in the evaluation of leukemia, lymphoma, and bone cancer.
Leukemia is a cancer that starts in the organs that make blood, namely the bone marrow and the lymph system.
The cells that make up blood are produced in the bone marrow and the lymph system.
The bone marrow is the spongy tissue found in the large bones of the body.
The bone marrow makes stem cells, which are the precursors of the different blood cells.
This uncontrolled proliferation of the immature cells in the bone marrow affects the production of the normal red blood cells and platelets as well.
The doctor may perform a bone marrow biopsy to confirm the diagnosis of leukemia.
Once the patient shows no obvious signs of leukemia (no leukemic cells are detected in blood tests and bone marrow biopsies), the patient is said to be in remission.
Bone marrow transplantation is a process in which the patient's diseased bone marrow is replaced with healthy marrow.
There are two ways of doing a bone marrow transplant.
In an allogeneic bone marrow transplant, healthy marrow is taken from a donor whose tissue is either the same as or very closely resembles the patient's tissues.
First, the patient's bone marrow is destroyed with very high doses of chemotherapy and radiation therapy.
In the second type of bone marrow transplant, called an autologous bone marrow transplant, some of the patient's own marrow is taken out and treated with a combination of anticancer drugs to kill all the abnormal cells.
This mode of bone marrow transplant is in the early 2000s being investigated in clinical trials.
Aplastic anemia-A disorder in which the bone marrow greatly decreases or stops production of blood cells.
Platelets, which are also called thrombocytes, are small disk-shaped blood cells produced in the bone marrow and involved in the process of blood clotting.
High platelet counts or low platelet counts sometimes indicate disorders of the bone marrow.
The primary functions of a platelet count are to assist in the diagnosis of bleeding disorders and to monitor patients who are being treated for any disease involving bone marrow failure.
It occurs in polycythemia vera and other disorders in which the bone marrow produces too many platelets.
Leukemia and aplastic anemia can result in a low platelet count because of decreased production of platelets in the bone marrow.
Abnormally high platelet levels (thrombocytosis) may indicate either a benign reaction to an infection, surgery, or certain medications; or a disease like polycythemia vera, in which the bone marrow produces too many platelets too quickly.
Other studies (chest x rays, CT scan of the lungs, bone marrow biopsy) may also be done in order to see if the tumor has spread to other locations.
In rare cases, bone marrow transplantation may be used.
If the bone marrow is involved, anemia can result.
They have transplanted bone marrow cells into living embryos in the uteri of animals to approach congenital diseases, birth defects, and mental retardation.
Lymphocytic leukemia-An acute form of childhood leukemia characterized by the development of abnormal cells in the bone marrow.
T cell-A type of white blood cell that is produced in the bone marrow and matured in the thymus gland.
Up to 95 percent of children who are treated with bone marrow transplants, especially those who are treated before three months of age, survive.
Children who are treated with bone marrow transplants have a much better prognosis.
Bcell-A type of white blood cell derived from bone marrow.
A complete blood count (CBC) reveals abnormalities in the blood and may indicate whether bone marrow has been affected.
For MPS I and VI, bone marrow transplantation has been attempted as a treatment option.
For those types of MPS, bone marrow transplantation has sometimes helped slow down the progression or reverse some of symptoms of the disorder in some children.
The benefits of bone marrow transplantation are more likely to be noticed when performed on children less than two years of age.
However, bone marrow transplantation is not thought to be helpful in other MPS disorders.
Availability of donors is limited, and as a result, very few bone marrow transplantations are done for MPS.
These include anemia, or breakdown of red blood cells; reduced platelets; reduced white cells; and bone marrow failure.
Heme is produced in several tissues in the body, but its primary biosynthesis sites are the liver and the bone marrow.
Heme synthesis for immature red blood cells, namely the erythroblasts and the reticulocytes, occurs in the bone marrow.
Hepatoerythopoietic porphyria (HEP) affects heme biosynthesis in both the liver and the bone marrow.
The specific symptoms of each porphyria vary based on which enzyme is affected and whether that enzyme occurs in the liver or in the bone marrow.
Severely affected patients may be offered bone marrow transplantation which appears to confer long-term benefit.
Erythropoiesis-The process through which new red blood cells are created; it begins in the bone marrow.
If the cancer appears to have spread beyond the eye, then other assessments such as a blood test, spinal tap (lumbar puncture), and/or bone marrow biopsy may be recommended.
In a bone marrow biopsy, a small amount of tissue (bone marrow) is taken from inside the hip or breast bone for examination.
The iron released from the RBCs is returned to the bone marrow to help create new cells.
Anemia due to vitamin C deficiency is a rare disorder that causes the bone marrow to manufacture abnormally small red blood cells.
It is the result of either infection or the presence of antibodies that destroy RBCs more rapidly than bone marrow can replace them.
Sometimes curable by bone marrow transplant, but potentially fatal, aplastic anemia is characterized by decreased production of red and white blood cells and platelets (disc-shaped cells that are a key component of blood coagulation).
In some anemias, a bone marrow sample will be removed (bone marrow biopsy) for microscopic examination, especially to confirm iron deficiency anemia or the megaloblastic anemias.
Children or young adults with thalassemia major may require periodic hospitalization to receive blood transfusions or, in some cases, bone marrow transplants.
Treatment for aplastic anemia may involve blood transfusions and bone marrow transplantation to replace malfunctioning cells with healthy ones.
Other cells that grow fast are cells of the bone marrow that produce blood cells, cells in the stomach and intestines, and cells of the hair follicles.
Low blood cell counts caused by the effect of chemotherapy on the bone marrow can lead to anemia, infections, and easy bleeding and bruising.
Most of these infants received experimental treatment including transfusions before birth, early delivery, and bone marrow transplantation before birth, although the latter procedure had, as of 2004, not yet been successful.
Bone marrow transplantation-A medical procedure in which a quantity of bone marrow is extracted through a needle from a donor, and then passed into a patient to replace the patient's diseased or absent bone marrow.
Common underlying disorders include leukemia, drug toxicity, or aplastic anemia, all of which lead to decreased or defective production of platelets in the bone marrow.
If these tests indicate that platelet destruction is causing the disorder, the physician may order a bone marrow biopsy.
As the infant's bone marrow begins to produce new red cells, fetal hemoglobin begins to decrease rapidly.
It may also reappear in adults when the bone marrow is overactive, as in disorders such as pernicious anemia, multiple myeloma, and invasive (metastatic) cancer affecting bone marrow.
Chronic leukemia is a disease in which abnormal, cancerous white blood cells are made in the bone marrow.
Chronic leukemia is a cancer that starts in the blood cells made in the bone marrow.
The bone marrow makes precursor cells called blasts or stem cells, which mature into different types of blood cells.
During the bone marrow biopsy, a cylindrical piece of bone and marrow is removed.
In addition to diagnosis, bone marrow biopsy is also done during the treatment phase of the disease to see if the leukemia is responding to therapy.
In BMT, the patient's diseased bone marrow is replaced with healthy marrow.
In an allogeneic bone marrow transplant, healthy marrow is taken from another person (donor) whose tissue is either the same or very closely resembles the patient's tissues.
This mode of bone marrow transplant is as of the early 2000s being investigated in clinical trials.
In chronic myeloid leukemia (CML), the treatment of choice is bone marrow transplantation.
In CML, if bone marrow transplantation is performed within one to three years of diagnosis, 50 to 60 percent of the patients survive three years or more.
A subsequent treatment for XHIM is bone marrow transplantation (BMT), which is also referred to as hematopoietic stem cell transplantation (HSCT).
The best source of bone marrow for transplantation is the affected child's siblings.
They will be tissue-typed to determine whether their bone marrow has the same human leukocyte antigens (HLA) as the affected child.
The closer the HLA match between a bone marrow donor and recipient, the lower the chances that the recipient's body will reject the transplanted tissue.
In addition to siblings, another choice is bone marrow from one of the parents, who shares half the affected child's HLA antigens.
With the expansion of bone marrow registries since the early 2000s, it is also possible to use bone marrow from an unrelated donor whose tissues closely match those of the affected child.
The most successful bone marrow transplants in hyper-IgM children, however, have used marrow donated by HLA-identical siblings.
However, researchers expect the outlook to improve for children in treatment in 2004, particularly those patients who are good candidates for bone marrow transplantation.
Such procedures as bone marrow or cord blood transplantation are also costly.
B cell-A type of white blood cell derived from bone marrow.
Stem cells from cord blood can be used in place of bone marrow for treating primary immunodeficiency disorders.
Human leuckocyte antigen (HLA)-A group of protein molecules located on bone marrow cells that can provoke an immune response.
The condition may also be associated with protein-losing enteropathy, low levels of iron in the blood serum or in the bone marrow (iron-deficiency anemia), or impaired absorption of nutrients by the intestines (malabsorption).
This type of anemia is caused by deficient erythropoiesis, the ongoing process of the bone marrow to produce healthy red blood cells (RBCs).
Iron is an essential component of the production of healthy RBCs, and iron stores must be maintained for the ongoing production of RBCs by the bone marrow.
Confirmation may also be obtained by taking a bone marrow sample (bone marrow biopsy) for microscopic examination.
If the deficiency is not treated (usually by bone marrow transplant), a person with SCID usually dies from infection before the age of two years.
In some severe cases, a bone marrow transplant or thymus transplant can be performed to correct the problem.
For most patients with SCID, bone marrow transplantation is necessary.
In this procedure, healthy bone marrow from a donor who has a similar type of tissue (usually a relative, such as a brother or sister) is removed.
The bone marrow of the person receiving the transplant is destroyed and is then replaced with marrow from the donor.
If a bone marrow transplant is not successfully performed, the child usually may not live beyond two years of age.
Chloramphenicol is not a first-choice drug because of its side effects, including interference with bone marrow production of blood cells.
Supportive care also includes monitoring of blood cell counts for patients using chloramphenicol, ampicillin, or other drugs that may affect production of blood cells by the bone marrow.
B cells are produced in the bone marrow and carried to the spleen, lymph nodes, and other organs as they mature.
Macrocytic cells occur when division of RBC precursor cells in the bone marrow is impaired.
Normocytic anemia may be caused by decreased production (e.g. malignancy and other causes of bone marrow failure), increased destruction (hemolytic anemia), or blood loss.
When fibrous or bony tissue invades bone marrow where red blood cells are made, the individual may develop anemia.
Because of the high risk of death, this procedure is done only with the most severely affected children where a good bone marrow match can be found.
About two-thirds of children who have severe malignant infantile osteopetrosis die before age ten unless they have a successful bone marrow transplant.
The more severe form of congenital osteopetrosis is usually fatal within the first ten years of life unless successfully treated with a bone marrow transplant.
Severe cases have been treated by transplantation of fetal thymus tissue or bone marrow.
Reacting to the anemia, the fetal bone marrow may release immature RBCs, or erythroblasts, into the fetal peripheral circulation, causing erythroblastosis fetalis.
The baby's body tries to compensate for the anemia by releasing immature red blood cells, called erythroblasts, from the bone marrow.
Deep bites or bites near joints can damage joints and bones, causing inflammation of the bone and bone marrow or septic arthritis.
Cord blood can help people who need bone marrow transplants, such as patients with leukemia, lymphoma, or genetic or immune disorders.
Since a bone marrow transplant requires a very close genetic match, it can be hard to match donors and recipients.
Cord blood does not have to match as closely, so it can sometimes be used when no bone marrow donor can be found.
It's also available more quickly; cord blood banks can supply a unit in about two weeks, instead of two months for bone marrow.
That's because your hair's cell system is the second most active cell system in the body, second only to bone marrow.
Yul Kwon has been busy promoting a charity to raise awareness of the need for minority bone marrow donors.
It is largely to researches on the bone marrow that we owe our present knowledge of the origin and the classification of the different cellular elements of the blood, both erythrocytes or red corpuscles, and the series of granular leucocytes or white corpuscles.
Whatever be the ancestral cell from which these cells spring, it is in the bone marrow that we find a differentiation into the various marrow cells from which are developed the mature corpuscles that pass from the marrow into the blood circulation.
The parasites are frequently more numerous in the spleen, bone-marrow, kidneys, &c., than elsewhere, and it has been found that multiplication goes on rather more actively in the capillaries of these organs.
B-cell (B lymphocyte)-A small white blood cell from bone marrow responsible for producing antibody and serving as a precursor for plasma cells.