More generally, over 100 molecules are in development as apoptosis agonists, although approaching 70% of these remain in preclinical development.
Nonetheless, it has been shown that, in certain cells, WT1 can induce cell-cycle arrest and apoptosis (Ref.
When a cell undergoes apoptosis, they have distinct morphological characteristics.
chromatin condensation is a major focus of our apoptosis studies.
The study of chromatin condensation is a major focus of our apoptosis studies.
Regulation of apoptosis in lymphomas and leukaemias, analysis of death effector mutations.
eosinophil apoptosis is induced.
The maintenance of tissue homeostasis is also aided by apoptosis, which acts to remove damaged, aged, autoimmune or malignant cells.
inducects mainly by inducing apoptosis of APL cells.
There appear to be two different pathways of ECM remodeling and apoptosis induction in POAG.
inhibition of apoptosis in normal cultures resulted in enhanced viral yield, comparable to that seen in infected asthmatic cultures.
Other inhibitors that have been identified include a number of inhibitors of apoptosis or " IAPs " .
We are seeking to unravel the relationship between DNA damage, apoptosis and the genomic instability of cancer.
involution of the mammary gland is a complex process of controlled apoptosis and tissue remodeling.
T cell receptor gene rearrangement problems contribute to thymic involution by making the cells less resistant to apoptosis.
Apoptosis is an important biological factor in low-grade lymphomas, and NO is able to prevent apoptosis.
Hughes et al ' Bisphosphonates promote apoptosis in murine osteoclasts in vitro and vivo ' .
MyoganeTM also increases neurite outgrowth, reverses oxidative damage and reverses neuronal apoptosis in vitro.
ribose polymerase, an abundant nuclear enzyme involved in DNA repair and apoptosis.
Overproduction also impaired a process called apoptosis, whereby damaged or unwanted cells self-destruct 14.
transduction inhibitors, and on the regulators of cell cycle checkpoints and modulators of apoptosis.
The C. elegans homolog of the p53 tumor suppressor is required for DNA damage induced apoptosis.
PARP is poly ADP ribose polymerase, an abundant nuclear enzyme involved in DNA repair and apoptosis.
His major focus has been on signal transduction inhibitors, and on the regulators of cell cycle checkpoints and modulators of apoptosis.
In the early 2000s ongoing research is focused on new treatment and prevention methods, including molecular-targeted therapies, virus therapy, immunotherapy, and drug therapy that stimulates the self-destruction of cancer cells (apoptosis).
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