Similarly a CH group may be replaced by a nitrogen atom with the production of compounds of similar stability; thus benzene gives pyridine, naphthalene gives quinoline and isoquinoline; anthracene gives acridine and a and 3 anthrapyridines.
The quinonoid structure of many coloured compounds has been proved experimentally, as, for example, by Hewitt for the benzene-azo-phenols, and Hantzsch for triaminotriphenyl methane and acridine derivatives; but, at the same time, many substances cannot be so explained.
Chemie, 24, p. 468) submitted the view that fluorescence was due to the presence of certain " fluorophore " groups; such groupings are the pyrone ring and its congeners, the central rings in anthracene and acridine derivatives, and the paradiazine ring in safranines.
This oscillation may be represented in the case of acridine and fluorescein as This theory brings the property of fluorescence into relation with that of colour; the forms which cause fluorescence being the coloured modifications: ortho-quinonoid in the case of acridine, paraquinonoid in the case of fluorescein.
This tautomerism may be of a twofold nature :-(I) it may involve the mere oscillation of linkages, as in acridine; or (2) it may involve the oscillation of atoms, as in fluorescein.
ACRIDINE, C13H9N, in chemistry, a heterocyclic ring compound found in crude coal-tar anthracene.
It may be separated by shaking out with dilute sulphuric acid, and then precipitating the sulphuric acid solution with potassium bichromate, the resulting acridine bichromate being decomposed by ammonia.
Many synthetic processes are known for the production of acridine and its derivatives.
Formic acid yields acridine, and the higher homologues give derivatives substituted at the meso carbon atom, N N +[[Hcooh-C 6 H 5 /Inc6h5->C6h4 C6h4 Cho Ch N N +Ch 3 000h->C 6 H 5 /IC 6 H 5 --C 6 H 4 C6h4 Coch 3 C]](CH3) Acridine may also 1:e obtained by passing the vapour of phenylortho-toluidine through a red-hot tube (C. Graebe, Ber., 1884, 17, p. 1 37 0); by condensing diphenylamine with chloroform, in presence of aluminium chloride (0.
Acridine and its homologues are very stable compounds of feebly basic character.
Acridine crystallizes in needles which melt at 110° C. It is characterized by its irritating action on the skin, and by the blue fluorescence shown by solutions of its salts.
Numerous derivatives of acridine are known and may be prepared by methods analogous to those used for the formation of the parent base.
Anschutz (Ber., 1884, 1 7, p. 439) estimates picric acid by precipitation with acridine.
Many derivatives are known, thus ortho-amino-benzophenone, melting at 106° C., can be obtained by reduction of the corresponding nitro compound; it condenses under the influence of heated lead monoxide to an acridine derivative and with acetone in presence of caustic soda it gives a quinoline.
Acridinic acid (quinoline-a0dicarboxylic acid) is formed when acridine is oxidized by potassium permanganate (C. Gracbe and H.
The next step was to use a fluorochrome (fluorescent stain) which is a powerful nuclear stain, namely, Acridine Orange.
Acridine crystallizes in needles which melt at 110Ã‚° C. It is characterized by its irritating action on the skin, and by the blue fluorescence shown by solutions of its salts.
Many derivatives are known, thus ortho-amino-benzophenone, melting at 106Ã‚° C., can be obtained by reduction of the corresponding nitro compound; it condenses under the influence of heated lead monoxide to an acridine derivative and with acetone in presence of caustic soda it gives a quinoline.
a-pyrone condenses with the benzene ring to form coumarin and isocoumarin; benzo-'y-pyrone constitutes the nucleus of several vegetable colouring matters (chrysin, fisetin, quercetin, &c., which are derivatives of flavone or phenyl benzo-y-pyrone); dibenzo--ypyrone is known as xanthone; related to this substance are fluorane (and fluorescein), fluorone, fluorime, pyronine, &c. The pyridine ring condenses with the benzene ring to form quinoline and isoquinoline; acridine and phenanthridine are dibenzo-pyridines; naphthalene gives rise to a-and /3-naphthoquinolines and the anthrapyridines; anthracene gives anthraquinoline; while two pyridine nuclei connected by an intermediate benzene nucleus give the phenanthrolines.
The word usage examples above have been gathered from various sources to reflect current and historial usage. They do not represent the opinions of YourDictionary.com.