The drug must be at once withheld if haemorrhages (subcutaneous, retinal, &c.) are observed.
These crystals are extremely resistant to absorption, are found in old blood clots, and have been known to persist in old cerebral haemorrhages after many years.
A widespread toxic action is indicated by the lesions found - cloudy swelling, which may be followed by fatty degeneration, in internal organs, capillary haemorrhages, &c. In septicaemia.
(Many such changes are usually grouped together under the heading of " inflammation " of varying degree--acute, subacute and chronic.) Degeneration and death of cells, haemorrhages, serous and fibrinous exudations, leucocyte emigration, proliferation of connective tissue and other cells, may be mentioned as some of the fundamental changes.
The changes produced at a distance by distribution of toxins may be very manifold - cloudy swelling and fatty degeneration, serous effusions, capillary haemorrhages, various degenerations of muscle, hyaline degeneration of small blood-vessels, and, in certain chronic diseases, waxy degeneration, all of which may be widespread, are examples of the effects of toxins, rapid or slow in action.