Crohn's disease: Also known as ileitis, regional enteritis, or granulomatous colitis, this disease is a form of inflammatory bowel disease characterized by severe, chronic inflammation of the wall of the GI tract.
In toxic doses podophyllin causes intense enteritis, with all its characteristic symptoms, and severe depression, which may end in death.
The symptoms of acute poisoning are pain and diarrhoea, owing to the setting up of an active gastro-enteritis, the foeces being black (due to the formation of a sulphide of lead), thirst, cramps in the legs and muscular twitchings, with torpor, collapse, convulsions and coma.
From this has developed the intramuscular injection of diluted sea-water in the treatment of gastro-enteritis, anaemia and various skin affections.
In concentrated or large doses lithium salts cause vomiting and diarrhoea, due to a gastro-enteritis set up by their action.