Except in osteoporosis, copper deficiency is rare, although dramatic changes in copper metabolism occur in two serious genetic diseases, Wilson disease and Menkes' disease.
Severe alterations in copper metabolism are seen in two rare genetic diseases: Wilson disease and Menkes' disease, which occur in about one in 100,000 births.
Children older than five years who have any form of liver disease are often evaluated for serum and cellular copper levels to determine if Wilson disease is present.
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