Vwf sentence example

vwf
  • The platelets stimulate the release other chemicals, called factors, which help form a strong permanent clot. vWF binds to and stabilizes factor VIII, one of the factors involved in forming the permanent clot.
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  • A deficiency or abnormality in vWF can interfere with the formation of the temporary platelet plug and affect the normal survival of factor VIII.
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  • Type 1 is the most common and mildest form and results when the body produces slightly decreased amounts of normal vWF.
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  • Type 2 can be classified into four subtypes (A, B, M, N) and results when the body produces an abnormal type of vWF.
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  • Type 3 is the rarest and most severe form and results when the body does not produce any detectable vWF.
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  • Different types of changes in the vWF gene can affect the production of vWF.
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  • Some changes cause the vWF gene to produce decreased amounts of normal vWF, while other changes cause the gene to produce abnormal vWF.
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  • Most of the vWF gene changes are significant enough that a change in only one vWF gene is sufficient to cause VWD.
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  • Type 1 VWD is called an autosomal dominant condition since it is caused by a change in only one vWF gene.
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  • Since type 1 VWD results in only a slight decrease in the amount of vWF produced, the symptoms are often mild and not apparent in some individuals.
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  • Most cases of type 2 VWD are autosomal dominant since a change in only one vWF gene results in the production of an abnormal form of vWF.
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  • Some cases of type 2 VWD and all cases of type 3 VWD are autosomal recessive, since they are caused only by changes in both vWF genes.
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  • Parents who have a child with an autosomal recessive form of VWD are called carriers, since they each possess at least one changed vWF gene.
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  • The severity of the disease is partially related to the amount and type of vWF that the body produces, but it is also influenced by other genetic and non-genetic factors.
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  • The amount of vWF produced by the body increases during pregnancy, so prolonged bleeding during delivery is uncommon in people with type 1 VWD.
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  • They also have a decreased amount of vWF and decreased vWF activity and usually have slightly decreased factor VIII levels and activity.
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  • Children with type 2 VWD have a prolonged bleeding time and decreased activity of vWF; they may also have decreased amounts of vWF and factor VIII and decreased factor VIII activity.
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  • Type 3 children have undetectable amounts of vWF, negligible vWF activity, factor VIII levels of less than 5 to 10 percent, and significantly reduced factor VIII activity.
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  • The activity of vWF is reduced for all types of VWD, making it the most sensitive means of identifying all three types.
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  • Once a person is diagnosed with VWD, further testing such as vWF multimer analysis and ristocetin-induced platelet aggregation (RIPA) should be performed to determine the subtype.
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  • Multimer analysis evaluates the structure of the vWF, and RIPA measures how much ristocetin is required to cause the clumping of platelets in a blood sample.
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  • The vWF multimer analysis is able to differentiate children with a structurally normal vWF (Type 1) from children with a structurally abnormal vWF (Type 2) and is often able to identify the subtype of patients with Type 2 VWD.
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  • Type 3 VWD should not be treated with DDAVP, since this medication does not increase the level of vWF in type 3 patients.
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  • Not all factor VIII concentrates can be used, since some do not contain enough vWF.
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  • If the factor VIII concentrates are unable to manage a severe bleeding episode, then blood products called cryoprecipitates, which contain concentrated amounts of vWF, or platelet concentrates should be considered.
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  • Estrogens, such as are found in oral contraceptives, increase the synthesis of vWF and can sometimes be used in the long-term treatment of women with mild to moderate VWD.
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  • Willebrand factor (vWF)-A protein found in the blood that is involved in the process of blood clotting.
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