He first settled in Egypt, hearing the lectures of Didymus, the Origenistic head of the catechetical school at Alexandria, and also cultivating friendly relations with Macarius the elder and other ascetics in the desert.
About the year 260 an Egyptian bishop, Nepos, in a treatise called 'XEyxos 6,XX yoptarCnv, endeavoured to overthrow the Origenistic theology and vindicate chiliasm by exegetical methods.
Not long afterwards, his attention having been called to the spread of Origenistic opinions in Syria, he issued an edict condemning fourteen propositions drawn from the writings of the great Alexandrian, and caused a synod to be held under the presidency of Mennas (whom he had named patriarch of Constantinople), which renewed the condemnation of the impugned doctrines and anathematized Origen himself.
He took a prominent part, on the orthodox side, in the Monophysite and Origenistic controversies.
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