Mefv sentence example
- Specific mutations in the MEFV gene are more common in certain ethnic groups and may cause a somewhat different course of the disease.
- Researchers think that a few mutations in the MEFV gene likely became common in a small population in the eastern Mediterranean several thousand years ago.
- Those who carried a single "beneficial" mutation in the MEFV gene were more likely to survive and reproduce, which may explain the high carrier frequency (up to one in five) in some populations.
- Mutations in the MEFV gene (short for Mediterranean fever) on chromosome number 16 are the underlying cause of FMF.
- Autosomal recessive inheritance means that a person with FMF has mutations in both copies of the MEFV gene.Advertisement
- If neither parent of a child with FMF has the condition, it means they carry one mutated copy of the MEFV gene, but also one normal copy, which is enough to protect them from disease.
- The MEFV gene carries the instructions for production of a protein called pyrin, named for pyrexia, a medical term for fever.
- Direct analysis of the MEFV gene for FMF mutations is the only method to be certain of the diagnosis.
- While it was as of 2004 not yet possible to detect all MEFV gene mutations that might cause FMF, successful cloning of the MEFV gene has led to a rapid test that can identify the most common mutations of the gene.
- The MEFV gene involved in FMF produces an unstable form of pyrin that fails to adequately control the inflammatory response.Advertisement