This enzyme is believed to be involved in the biosynthesis of isoleucine in methanogens and possibly other species lacking threonine dehydratase.
ALA dehydratase deficiency porphyria (step 2).
ADP is characterized by a deficiency of ALA dehydratase.
ADP is caused by mutations in the delta-aminolevulinate dehydratase gene (ALAD) at 9q34.
Given the rarity of ALA dehydratase porphyria, definitive treatment guidelines for this rare type have not been developed.
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