It can be obtained by the oxidation of uric acid by means of lead dioxide, manganese dioxide, ozone or potassium permanganate: C 5 H 4 N 4 O 3 + H 2 O + O = C 4 H 6 N 4 O 3 + C02.
A continuation of their work on bitter almond oil by Liebig and Wohler, who remained firm friends for the rest of their lives, resulted in the elucidation of the mode of formation of that substance and in the discovery of the ferment emulsin as well as the recognition of the first glucoside, amygdalin, while another and not less important and far-reaching inquiry in 'which they collaborated was that on uric acid, published in 1837.
Parasites, tuberculosis; (0) on the ground that the flesh of artificially fed animals is full of excretory substances, and that, therefore, under modern conditions, flesh-eating is injurious, and may be a cause of excretory substance and uric acid deposits or rapid tissue-destroying diseases in man; e.g.
It is used in medicine on account of the high solubility of its salt with uric acid.
'They are quickly excreted in the urine, rendering it alkaline and thus more able to hold uric acid in solution.
They also hinder the formation of uric acid calculi.
Papers published in 1776 were concerned with quartz, alum and clay and with the analysis of calculus vesicae from which for the first time he obtained uric acid.
ALLOXAN, or Mesoxalyl Urea, C 4 H 2 N 2 0 4 or CO NCO an oxidation product of uric acid, being NNH - CO/ obtained from it by the action of cold nitric acid, C 5 H 4 N 4 03 -}- H 2 O + 0= C4H2N204 -FCO(NH 2) 2.
Methyl and dimethylalloxans are also known, the former being obtained on oxidation of methyl uric acid, and the latter on oxidation of caffeine.
One of the earliest, if not the earliest, was the investigation, published in 1830, which proved the polymerism of cyanic and cyanuric acid, but the most famous were those on the oil of bitter almonds (benzaldehyde) and the radicle benzoyl (1832), and on uric acid (1837), which are of fundamental importance in the history of organic chemistry.
It is closely allied to theobromine, the alkaloid of cocoa, and also to uric acid.
Soc. Chinn., 18 93 , 9, p. 427); and by oxidation of uric acid.
Parabanic acid (oxalyl urea), C0[NH C0] 21 is formed by oxidizing uric acid; or by condensing oxalic acid and urea in the presence of phosphorus oxychloride.
The waters of Baden-Baden are specific in cases of chronic rheumatism and gout, paralysis, neuralgia, skin diseases and various internal complaints, such as stone and uric acid.
It was originally introduced into medicine as a solvent for uric acid.
Outside the body piperazin has a remarkable power of dissolving uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful.
Acetoacetic ester is a most important synthetic reagent, having been used in the production of pyridines, quinolines, pyrazolones, furfurane, pyrrols, uric acid, and many complex acids and ketones.
In health most of the nitrogenous waste in the body is eliminated as urea, but in gout uric acid is either formed in too great quantity or too little is eliminated, so that it tends to be deposited as urate of soda in the joints and other tissues.
One is to put the patient on an almost complete vegetarian diet, so as to limit both the amount of uric acid introduced into the body as well as its formation in the body.
To celebrate his seventieth birthday his scientific papers were collected and published in two volumes (Gesammelte Werke, Brunswick, 1905), and the names of the headings under which they are grouped give some idea of the range and extent of his chemical work: (1) organic arsenic compounds, (2) uric acid group, (3) indigo, (4) papers arising from indigo researches, (5) pyrrol and pyridine bases, (6) experiments on the elimination of water and on condensation, (7) the phthaleins, (8) the hydro-aromatic compounds, (9) the terpenes, (io) nitroso compounds, (11) furfurol, (12) acetylene compounds and "strain" (Spannungs) theory, (13) peroxides, (14) basic properties of oxygen, (15) dibenzalacetone and triphenylamine, (16) various researches on the aromatic and (17) the aliphatic series.
The uric acid excreted in the urine (mostly in the form of urates) is markedly diminished.
This product is largely derived from the nuclei of the leucocytes, which contain large quantities of the nucleo-proteids, of which uric acid is a decomposition product.
Lithium salts render the urine alkaline and are in virtue of their action diuretic. They are much prescribed for acute or chronic gout, and as a solvent to uric acid calculi or gravel, but their action as a solvent of uric acid has been certainly overrated, as it has been shown that the addition of medicinal doses of lithium to the blood serum does not increase the solubility of uric acid in it.
It is slightly diuretic. Experimentally it has been shown to have a solvent action on uric acid, but its action in this direction in the body requires confirmation.
The formation of murexide is used as a test for the presence of uric acid, which on evaporation with dilute nitric acid gives alloxantin, and by the addition of ammonia to the residue the purple red colour of murexide becomes apparent.
These tubes are shown to excrete nitrogenous waste products similar to uric acid.