Thiourea and many of its unsymmetrical derivatives have marked physiological action; thiourea causes a slowing of the pulse and respiration, cardiac failure, and death in convulsions; phenyl-, ethyland acetyl-thiourea are actively toxic. The most important derivative pharmacologically is allyl-thiourea, also known as thiosinamine or rhodallin, NH2 CS NH CH2 CH:CH2.
By using urea, guanidine, thiourea and related compounds instead of amidines, one obtains the uracils.
Nencki has shown that alloxan combines with thiourea in alcoholic solution, in the presence of sulphur dioxide to form pseudothiouric acid, C 5 H 6 N 4 S0 3.
Thiourea, or sulphocarbamide, CS(NH 2) 2, is formed by prolonged fusion of ammonium thiocyanate (E.