In 1829 he went to Halle as professor to teach church history, dogmatics and symbolics, but in 1836 he accepted a chair at Heidelberg.
Here in 1 754 he became professor extraordinarius of theology, and three years later received an ordinary professorship. He lectured on dogmatics, church history, ethics, polemics, natural theology, symbolics, the epistles of Paul, Christian antiquities, historical theological literature, ecclesiastical law and the fathers, and took an active interest in the work of the Gottinger Societdt In 1766 he was appointed professor primarius.
Marheineke is named as the first writer (1810) on Symbolics, the comparative study of creeds and confessions of faith.
Symbolics is to be a branch of statistics.