When a second mutation occurs, the cell that contains the mutation no longer has any normal copy of the tumor suppressor gene.
An RB1 gene is non-functional when it is changed or missing (deleted) and no longer produces normal tumor suppressor protein.
RB1 produces a tumor suppressor protein that normally helps to regulate the cell cycle of cells such as those of the retina.
Normally, the tumor suppressor protein produced by RB1 prevents a retinal cell from becoming cancerous.
PYGM is one of a group of genes known as tumor suppressor genes that help to control cell division.
Genes such as tumor suppressor genes tightly regulate this growth cycle.
Each RB1 gene produces tumor suppressor protein.
The earlier legend knows Minos as a beneficent ruler, legislator, and suppressor of piracy (Thucydides i.