The walls and vault of this chapel are covered with some of the best-preserved and finest frescoes in Italy - among the noblest works of Fra Angelico and Luca Signorelli, mainly painted between 1450 and 1501 - the latter being of especial importance in the history of art owing to their great influence on Michelangelo in his early days.
The cathedral, originally a Tuscan Romanesque building of the 11th-12th centuries, is now a fine Renaissance basilica restored in the 18th century, containing some paintings by Luca Signorelli, a native of the place.
Spirito are two paintings by Luca Signorelli, the "Crucifixion" and the "Day of Pentecost," originally intended for a processional banner.
The monastery of Monte Oliveto Maggiore is an extensive building of considerable artistic interest, enhanced by frescoes of Signorelli and Sodoma; it is now a national monument occupied by two or three monks as custodians, though it could accommodate three hundred.
Six miles to the south is the large Benedictine monastery of Monte Oliveto Maggiore, founded in 1320, famous for the frescoes by Luca Signorelli (1497-1498) and Antonio Bazzi, called Sodoma (1505), in the cloister, illustrating scenes from the legend of St Benedict; the latter master's work is perhaps nowhere better represented than here.