While water containing much saline matter, and more especially water containing free carbonic acid, has a very stimulating action upon the skin, mud has a sedative effect, so that in a mud-bath one feels a pleasant soothing sensation as if bathing in cream.
They are very astringent, haemostatic and sedative; the strong solution of the subacetate is powerfully caustic and is rarely used undiluted.
Hence bromide of potassium - or bromide of sodium, which is possibly somewhat safer still though not quite so certain in its action - is used as a hypnotic, as the standard anaphrodisiac, as a sedative in mania and all forms of morbid mental excitement, and in hyperaesthesia of all kinds.
In whooping-cough, when a sedative is required but a stimulant is also indicated, ammonium bromide is often invaluable.
Sean was supposed to serve her dessert laced with a sedative, so they could drug her and take her back to the station for questioning.
Lead salts are applied as lotions in conditions where a sedative astringent effect is desired, as in weeping eczema; in many varieties of chronic ulceration; and as an injection for various inflammatory discharges from the vagina, ear and urethra, the Liquor Plumbi Subacetatis Dilutum being the one employed.
The extreme pain and rapid swelling of the vocal cords - with threatened obstruction to the respiration - that characterize acute laryngitis may often be relieved by the sedative action of this drug upon the circulation.
"An air more delicious to breathe," wrote Bayard Taylor, "cannot anywhere be found; it is neither too sedative nor too exciting, but has that pure, sweet, flexible quality which seems to support all one's happiest and healthiest moods."
Thus in the eye and ear, lotions containing an antiseptic, a sedative and an astringent are very generally used.
Fraser proved that by substitution of molecules in certain compounds a stimulant could be converted into a sedative action; thus by the addition of the methyl group CH 2 to the molecule of strychnine, thebaine or brucine, the tetanizing action of these drugs is converted into a paralysing action.