The salicylate of colchicine is stable in water and may be given in doses of about one-thirtieth of a grain.
It is obtained by the oxidation of xanthene (methylene diphenylene oxide) with chromic acid; by the action of phosphorus oxychloride on disodium salicylate; by heating 2 2'-dioxybenzophenone with concentrated sulphuric acid; by distilling fluoran with lime; by the oxidation of xanthydrol (R.
Sodium phenolate is heated in a stream of carbon dioxide in an iron retort at a temperature of 180-220° C., when half the phenol distils over and a basic sodium salicylate is left.
When boiled with calcium chloride and ammonia, salicylic acid gives a precipitate of insoluble basic calcium salicylate, C 6 H 4 ‹ 0 2 i Ca, a reaction which serves to distinguish it from the isomeric metaand para-hydroxybenzoic acids.
Methyl Salicylate, C,H 4 (OH) CO 2 CH 31 found in oil of wintergreen, in the oil of Viola tricolor and in the root of varieties of Polygala, is a pleasant-smelling liquid which boils at 222° C. On passing dry ammonia into the boiling ester, it gives salicylamide and dimethylamine.
Ethyl salicylate, C 6 H 4 (OH) CO 2 C 2 H 5j is obtained by boiling salicylic acid with alcohol and a little sulphuric acid, or by dropping an alcoholic solution of salicylic acid into 13-naphthalene sulphonic acid at a temperature of 140-150° C. (German Patent 76,574).
Phenyl salicylate, C6H4(OH) C 02C6H5, or salol, is obtained by heating salicylic acid, phenol and phosphorus oxychloride to 120-125° C.; by heating salicylic acid to 2 =0° C.; or by heating salicyl metaphosphoric acid and phenol to 140-150° C. (German Patent 85,565).
Sodium salicylate circulates in the blood unchanged, decomposition occurring in the kidney, and probably in tissues suffering from the Diplococcus rheumaticus of Poynton and Paine.
It has now been established that, provided the kidneys be healthy, natural salicylic acid, sodium salicylate prepared from the natural acid, and salicin, are not cardiac depressants.
At first 20 grains of sodium salicylate should be given every hour: the interval being doubled as soon as the pain disappears, and extended to three hours when the temperature becomes normal.
Salicylate of soda may occasionally be of use in cases of gallstone, owing to its action on the bile.
We should expect to find supersolubility curves lying below the solubility curves, and this result has been realized experimentally for the supersolubility curves of mixtures of salol (phenyl salicylate) and betol (/3-naphthol salicylate) represented by the dotted lines of fig.
Fibrolysin is a modified form of thiosinamine made by mixing it with sodium salicylate Fibrolysin is freely soluble and may be given in hypodermic or intra-muscular injection.
A number of salts of thorium have been prepared for therapeutic use, including the hydroxide, nitrate, salicylate, oleate and lactate.
Others which may be mentioned are salicylate of bismuth, salol, 0-naphthol and naphthalene.
The proprietary drug " stypticin " is cotarnine hydrochloride, and " styptol " cotarnine phthalate; " antispasmin " is a sodium narceine combined with sodium salicylate, and " narcyl " narceine ethyl hydrochloride.
In acute attacks of rheumatism the remedy par excellence is salicylate of soda, which reduces the temperature, relieves the pain, and removes the swellings from the joints.
In chronic rheumatism the chief remedies are salicylate of soda, and its allies iodide of potassium, guaiacum and sulphur, while massage, liniments and baths are beneficial as local applications.
Sodium salicylate escapes from the blood mainly by the kidneys, in the secretion of which sodium salicylate and salicyluric acid can be detected within fifteen minutes of its administration.