It must not be imagined that so great a change as that implied by the Renaissance was accomplished without premonitory symptoms and previous endeavours.
Political jealousies and interests intensified the disputes, and at last, after many premonitory symptoms, the final break came in 1054, when Pope Leo IX.
Clinically, dysentery manifests itself with varying degrees of intensity, and it is often impossible without microscopical examination to determine between the amoebic and bacillary forms. In well-marked cases the following are the chief symptoms. The attack is commonly preceded by certain premonitory indications in the form of general illness, loss of appetite, and some amount of diarrhoea, which gradually increases in severity, and is accompanied with griping pains in the abdomen (tormina).