If the white cells be required, as in local suppurating abscess, general septicaemia, acute pneumonia, &c., there is an active proliferation of the myelocytes to form the polymorpho-nuclear leucocytes, so that we have in this condition a leucoblastic transformation of the fatty marrow.
This is an increased exudation of fluid from the engorged blood vessels which not only dilutes the toxins, but is supposed to contain substances which in some way act on these living micro-organisms and render them a more easy prey to the polymorpho-nuclear leucocytes (fig.
The polymorpho-nuclear leucocytes are seen in great numbers in the blood vessels.
To replace this cellular destruction there has been a demand for reinforcements on the home centres of the polymorpho-nuclear leucocytes - the bone marrow.
This call is immediately answered by an active proliferation and steady maturing of the myclocytes in the marrow to form the polymorpho-nuclear leucocytes.
It has been proved that the pyo-genic bacterial toxins, if not too concentrated, will attract the polymorpho-nuclear leucocytes, but if concentrated, may have a repelling influence.
As soon as the fluids and the polymorpho-nuclear leucocytes have :succeeded in diminishing the virulence of the micro-organism, the second line of defenders - the large mononuclear leucocytes (fig.
The first defenders, the polymorpho-nuclear leucocytes, having performed their functions, are of no more use to the organism and are therefore removed by the mono-nuclear phagocytes as useless material (fig.
As early as six hours after the injury the polymorpho-nuclear leucocytes are seen passing in large numbers from the dilated and congested blood vessels of the tissues at the margin of the wound into the injured zone, where they carry on an active phagocytosis.
A small cellular area formed by emigrated polymorpho nuclear leucocytes surrounding a central mass of bacteria.
The mono-nuclear cells are ingesting and digesting many of the polymorpho-nuclear leucocytes.