He spent much of his time in practising magic, and it was believed that he had so saturated his body with poisons that none could injure him.
An electuary of opium, known as Mithradatum, was invented by Mithradates VI., king of Pontus, who lived in constant fear of being poisoned, and tested the effects of poisons on criminals, and is said to have taken poisons and their antidotes every day in the year.
The subjects included are systematic botany, vegetable morphology and physiology, chemistry, physics, materia medica, pharmacy, dispensing, posology, the reading of prescriptions, and a knowledge of poisons and their antidotes.
The Poisons and Pharmacy Act of 1908 (section 4) has given the society power to regulate the preliminary training, arrange a curriculum, and divide the qualifying examination into two parts, so that an approximation to the standard of pharmaceutical education on the Continent is likely to take place within a short period.
A subsequent pharmacy act, passed in 1868, added a register of chemists and druggists, and rendered it unlawful for any unregistered person to sell or keep open shop for selling the poisons mentioned in the schedule of this act.
The Poisons and Pharmacy Act of 1908 extended the schedule of poisons instituted by the act of 1868, and it now includes arsenic, aconite, aconitine and their preparations; all poisonous vegetable alkaloids, and their salts and poisonous derivatives; atropine and its salts and their preparations; belladonna and all preparations or admixtures (except belladonna plasters) containing 0.1% or more of belladonna alkaloid; cantharides and its poisonous derivatives; any preparation or admixture of coca-leaves containing 0.1% or more of coca alkaloids; corrosive sublimate; cyanide of potassium and all poisonous cyanides and their preparations; tartar emetic, nux vomica, and all preparations or admixtures containing 0.2% or more of strychnine; opium and all preparations and admixtures containing 1% or more of morphine; picro-toxine; prussic acid and all preparations and admixtures containing o i% or more of prussic acid; savin and its oil, and all preparations or admixtures containing savin or its oil.
The following poisons may not be sold, either retail or wholesale, unless distinctly labelled with the name of the article, and the word poison, with the name and address of the seller: Almonds, essential oil of (unless deprived of prussic acid).
Any poisonous substance that is not included in the schedules can be sold by anyone, as, for instance, red lead, sulphate of copper, &c. The duty of the Pharmaceutical Society is a purely legal one, and relates only to the schedules of poisons framed by the government to protect the public by rendering it a difficult matter to obtain the poisons most frequently used for criminal purposes.
In response to an agitation originated by certain manufacturers (one of whom was a member of parliament), who were prosecuted for omitting to label arsenical and nicotine preparations as poisons, as required by the Pharmacy Act of 1868, a new act was passed in 1908, by which persons, without any training in toxicology, and being neither pharmaceutical chemists, nor chemists and druggists, may be granted licences by local authorities to sell poisonous substances used exclusively in agriculture or horticulture, for the destruction of insects, fungi or bacteria, or as sheep dips or weedkillers, but which are poisonous by reason of containing the scheduled poisons, arsenic or nicotine, &c. One condition concerning the granting of such licences has been, it is said, deliberately ignored in many towns, viz.
In Russia a prescription containing any of the poisons indicated in the schedules A and B in the Russian pharmacopoeia may not be repeated, except by order of the doctor.
The now well-known fact that small doses of poisonous substances may act as stimuli to living protoplasm, and that respiratory activity and growth may be accelerated by chloroform, ether and even powerful mineral poisons, such as mercuric chloride, in minimal doses, offers some explanation of these phenomena of hypertrophy, wound fever, and other responses to the presence of irritating agents.
Still further insight is afforded by our increasing knowledge of the enzymes, and it is to be remarked that both poisons and enzymes are very common in just such parasitic Fungi as induce discolorations, hypertrophies and the death of cellse.g.
If the attack of a parasite is met by the formation of some substance in the protoplasm which is chemo- tactically repulsive to the invader, it may be totally incapable of penetrating the cell, even though equipped with a whole armoury of cytases, diastatic and other enzymes, and poisons which would easily overcome the more passive resistances offered by mere cell-walls and cell-contents of other plants, the protoplasm of which forms bodies chemotactically attractive to the Fungus.
The inability to enter the cells may be due to the lack of chemotactic bodies, to incapacity to form cellulose-dissolving enzymes, to the existence in the hostcells of antagonistic bodies which neutralize or destroy the acids, enzymes or poisons formed by the hyphae, or even to the formation and excretion of bodies which poison the Fungus.
In other cases the presence of insects, Fungi or poisons at the roots may be looked for.
The breathing becomes shallow, the drug killing, like nearly all neurotic poisons (alcohol, morphia, prussic acid, &c.), by paralysis of the respiratory centre, and the patient dying in a state of coma.
At the same time a class of men arose interested in these forms for their own sake, professional lawyers Bence, but also "poisons, nay destroys, the divinest feeling in man, the sense of truth," and the belief in sacraments such as the Lord's Supper, a piece of religious materialism of which "the necessary consequences are superstition and immorality."
Progress in forensic chemistry was only possible after the reactions of poisons had been systematized; a subject which has been worked out by many investigators, of whom we notice K.
Since all soluble lead compounds are strong cumulative poisons, danger is involved in using lead cisterns or pipes in the distribution of pure waters.
Over and above the bacterial intoxications we have a very extreme degree of fatty degeneration, widely distributed throughout the tissues, which is produced by certain organic and inorganic poisons; it is seen especially in phosphorus and chloroform poisoning.
Certain metallic poisons give rise to pigmentation of the tissues, e.g.
Trans., London, 1894); Heidenhain, " Action of Poisons on Nerves of Submaxillary Gland," Arch.
His Mechanical Account of Poisons, in the first edition (1702), gave an explanation of the effects of poisons, as acting only on the blood.
In the effects of simpler poisons the recognition of unity in diversity, as in the affiliation of a peripheral neuritis to arsenic, illustrated more definitely this serial or etiological method of classifying diseases.
Even in normal circumstances their play and counterplay, attractive and repellent, must be manifold almost beyond conception; for the body may be regarded as a collective organization consisting of a huge colony of micro-organisms become capable of a common life by common and mutual arrangement and differentiation of function, and by toleration and utilization of each other's peculiar products; some organs, such as the liver, for example, being credited with a special power of neutralizing poisons, whether generated under normal conditions or under abnormal, .which gain entrance from the intestinal tract.
Here we enter upon one of the most interesting chapters of disorders and modes of disorder of this and of other systems. It has come out more and more clearly of late years that poisons do not betray even an approximately indifferent affinity for all tissues, which indeed a little reflection would tell us to be a priori improbable, but that each tends to fix itself to this cell group or to that, picking out parts for which they severally have affinities.
With changes of the pressures of the blood in arteries, veins or capillaries, and in the heart itself and its respective chambers, static changes are apt to follow in these parts; such as degeneration of the coats of the arteries, due either to the silent tooth of time, to persistent high blood pressures, or to the action of poisons such as lead or syphilis.
Griesinger (1817-1868), Bevan Lewis - and in the separation from insanity due to primary disease or defect of nerve elements of such diseases as general paralysis of the insane, which probably arise, as we have said, by the action of poisons on contiguous structures - such as blood-vessels and connective elements - and invade the nervous matter secondarily.
In our conceptions of the later stages of assimilation and of excretion, with the generation of poisons (auto-intoxication) in the intestinal tract, there is still much obscurity and much guess-work; yet in some directions positive knowledge has been gained, partly by the physiologist, partly by the physician himself.
Of such are the better understanding of the functions of the liver in normal catabolism, in the neutralization of poisons absorbed from the intestines or elsewhere, in the causation of jaundice, and in diabetes [Bernhardt Naunyn (b.
Sage holds the place of honour; then comes rue, the antidote of poisons; and so on through melons, fennel, lilies, poppies, and many other plants, to wind up with the rose, "which in virtue and scent surpasses all other herbs, and may rightly be called the flower of flowers."
Nicander of Colophon has also left us two epics, one on remedies for poisons, the other on the bites of venomous beasts.
Capture begins among the lower tribes with the hand, without devices, developing knack and skill in seizing, pursuing, climbing, swimming, and maiming without weapons; and proceeds to gathering with devices that take the place of the hand in dipping, digging, hooking and grasping; weapons for striking, whether clubs, missiles or projectiles; edged weapons of capture, which were rare in America; piercing devices for capture, in lances, barbed spears, harpoons and arrows; traps for enclosing, arresting and killing, such as pens, cages, pits, pen-falls, nets, hooks, nooses, clutches, adhesives, deadfalls, impalers, knife traps and poisons; animals consciously and unconsciously aiding in capture; fire in the form of torches, beacons, burning out and smoking out; poisons and asphyxiators; the accessories to hunting, including such changes in food, dress, shelter, travelling, packing, mechanical tools and intellectual apparatus as demanded by these arts.
The other, Alexipharmaca, consists of 630 hexameters treating of poisons and their antidotes.
His psychology poisons his logic.
Orfila's chief publications are Traite des poisons, or Toxicologie ge'nerale (1813); Elements de chimie medicale (1817); Lecons de medecine legale (1823); Traite des exhumations juridiques (1830); and Recherches sur l'empoisonnement par l'acide arsenieux (1841).
It is a vast mine of experimental observation on the symptoms of poisoning of all kinds, on the appearances which poisons leave in the dead body, on their physiological action, and on the means of detecting them.
Such are sugars (glucose, mannite, &c.), acids (acetic, citric and a whole series of lichen-acids), ethereal oils and resinous bodies, often combined with the intense colours of fungi and lichens, and a number of powerful alkaloid poisons, such as muscarin (Amanita), ergotin (Claviceps), &c.
The neuron is described as having a cell body or perikaryon from which the cell branches - dendrites and axon - extend, and it is this perikaryon which, as its name implies, muscle produces lactic acids during activity, it has been suggested that acids are among the "fatigue substances" with which muscle poisons itself when deprived of circulating blood.
The hydrochloric acid from the calcining-furnaces or "roasters" cannot be employed immediately for the Deacon process, as the sulphuric acid always contained in the roaster gases soon " poisons " the contact-substance and renders it inoperative.
These enter the body through various channels, and once they have effected a lodgment they grow, multiply and give rise to various poisons which attack and injure or destroy different tissues or organs in the body.
Poisons formed by microbes are partly eliminated by the kidneys, partly by the mucous membrane of the stomach and intestines, and possibly also by the skin.
But the delirium which is common in fever, although it may be partly due to rise of temperature, is very often due to poisons in the blood, for in some cases it occurs with quite a low temperature, 101° or 102°, whereas in others the temperature rises to zoo° and 105° with no delirium whatever.
The food thus reaches the stomach in large lumps which cannot be readily digested, and either remain there till they decompose and give rise to irritation in the stomach itself, or pass on to the intestine, where digestion is likewise incomplete, and the food is ejected without the proper amount of nourishment having been extracted from it; while at the same time the products of its decomposition may have been absorbed and acted as poisons, giving rise to lassitude, discomfort, headache, or perhaps even to irritability and sleeplessness.
==Toxicology== Antimony is one of the "protoplasmic" poisons, directly lethal to all living matter.
It was also shown that exposure to light, dilution or exhaustion of the food-media, the presence of traces of poisons or metabolic products check growth or even bring it to a standstill; and the death or injury of any single cell in the filamentous series shows its effect on the curve by lengthening the doubling period, because its potential progeny have been put out of play.
The addition of minute traces of acids, poisons, &c., leads to this change in some forms; high temperature has also been used successfully.
These facts, and the further knowledge that many bacteria never observed as parasites, or as pathogenic forms, produce toxins or poisons as the result of their decompositions and fermentations of organic substances, have led to important results in the applications of bacteriology to medicine.
Little is known of the mode of action of bacteria on these plants, but it may be assumed with great confidence that they excrete enzymes and poisons (toxins), which diffuse into the cells and kill them, and that the effects are in principle the same as those of parasitic fungi.
Though the causal relationship of a bacterium to a disease may be completely established by the methods given, another very important part of bacteriology is concerned with the poisons or toxins formed by bacteria.