Phagocytes act as scavengers in ridding the body of noxious particles, and more especially of harmful bacteria.
The vanguard of this advancing army is composed of a more or less compact layer of the mono-nuclear phagocytes (polyblasts) accompanied by numerous new vessels.
Given a noxious agent in a tissue, such, let us say, as a localized deposit of certain bacteria, the phagocytes swarm towards the locality where the bacteria have taken up their residence.
This is accomplished by a twofold agency, for while numbers of them are seized upon by the granulation phagocytes, others are broken up and dissolved by the liquid filling the granulation interspaces (Afanassieff).
He also showed that the development of artificial immunity is attended by the appearance of phagocytosis; also, when an anti-serum is injected into an animal, the phagocytes which formerly were indifferent might move towards and destroy the bacteria.
It has, however, been demonstrated that the senile whitening of human hair is due to the presence of phagocytes, which devour the pigment-bodies; and from microscopic observations recently made by the French naturalist Dr E.
The phagocytes are attracted from the blood vessels and elsewhere towards the noxious focus by the chemiotaxis exerted upon them by the toxins secreted by the bacteria contained within it.
The chemiotaxis in this instance is positive, but the toxins from certain other bacteria may act negatively; and such bacteria are fraught with particular danger from the fact that they can spread through the body unopposed by the phagocytes, which may be looked upon as their natural enemies.
224, also a number of other papers bearing upon lymph-production, in same; Thorne, " Endothelia as Phagocytes," Arch.
We have no distinct proof that there occurs in active immunity any education of the phagocytes, in Metchnikoff's sense, that is, any increase of the inherent ingestive or digestive activity of these cells.
Then as regards natural powers of destroying bacteria, phagocytosis aided by chemiotaxis plays a part, and it can be understood that an animal whose phagocytes are attracted by a particular bacterium will have an advantage over one in which this action is absent.
Under the influence of exposure to intense cold a small mammal has been observed to turn white in a single night, just as the human hair has been known to blanch suddenly under the influence of intense emotion, and in both cases extreme activity of the phagocytes is apparently the inducing cause.
Ingestion and dissolution of the Trypanosomes by phagocytes has frequently been observed; and it is probable also that the haematopoietic organs secrete some substance which exerts a harmful action on the parasites, and causes them to undergo involution and assume weird-looking " amoeboid " and " plasmodial " forms.
This reaction is carried out by the mobile phagocytes sometimes alone, sometimes with the aid of the vascular phagocytes, or of the nervous system."