From 1738 to 1741 he was placed in the care of an oculist, as he suffered from inflammation of the eyes.
The oculist uses it for at least six purposes.
ALBRECHT VON GRAFE (1828-1870), German oculist, son of Karl Ferdinand von Grafe, was born at Berlin on the 22nd of May 1828.
He started business as a clock, lock and tool maker at Doncaster, and attained a considerable local reputation for scientific knowledge and skilled workmanship. He also practised surgery in an experimental fashion, and was frequently consulted as an oculist.
For the use of the oculist, who constantly employs this drug, it is also prepared in lamellae for insertion within the conjunctival sac. Each of these contains one-thousandth part of a grain of physostigmine sulphate, a quantity which is perfectly efficient.
After prosecuting his studies at Berlin, Vienna, Prague, Paris, London, Dublin and Edinburgh, and devoting special attention to ophthalmology he, in 1850, began practice as an oculist in Berlin, where he founded a private institution for the treatment of the eyes, which became the model of many similar ones in Germany and Switzerland.