Phosphates, necessary for the formation of skeletons and also for the nucleo-proteid of cells, are about as scarce as nitrogen.
Phosphorus containing albumins (nucleo-albumins), caseins, vitellines, nucleo-albumins of the cellprotoplasm, mucoid nucleo-albumins.
The nucleo-albumins or phospho-globulins are insoluble in water and acids, but soluble in alkalies, and have an acid reaction.
Kossel) they give rise to important cell constituents - haemoglobin, nucleo-proteids, &c. " Thymus histone " occurs in the thymus gland; globin occurs in combination as haemoglobin; other histones have been extracted from the red blood corpuscles of the goose and the testes of fishes and other animals.
" Nucleo-proteids," constituents of the cell-nucleus, are combinations of albumins and nucleic acid; they always contain iron.
An important nucleo-proteid is haemoglobulin or haemoglobin, the colouring matter of the red blood corpuscles of vertebrates; a related substance, haemocyanin, in which the iron of haemoglobin is replaced by copper, occurs in the blood of cephalopods and crayfish.
" Glyco-proteids " differ from nucleo-proteids in containing a carbohydrate radical, which is liberated only by boiling with mineral acids or alkalies.
Brodie, in ascertaining the physiological properties of nucleo-proteids, found that when they were intravascularly injected into pigmented rabbits, coagulation of the blood resulted, but of the eight albinoes which they used, none clotted.
Moreover, it was found that all the failures of coagulation occurred when the nucleo-proteid used was obtained from pigmented animals.
All pigmented animals clotted when the nucleo-proteid was derived from either source.
The Himalayan rabbits reacted like complete albinoes, and 12% of them failed to clot when injected with nucleo-proteid extracted from pigmented animals.
It was found that the resistance of albinoes towards the coagulative effects of injected nucleo-proteids was to that of pigmented individuals as.
This product is largely derived from the nuclei of the leucocytes, which contain large quantities of the nucleo-proteids, of which uric acid is a decomposition product.