Hoffmann (52) from essential syphilitic lesions, and now known as Treponeina (Spirochaete) pallida, Schaud.
In man, actually gross sensory defects follow even limited lesions of the cortex.
A widespread toxic action is indicated by the lesions found - cloudy swelling, which may be followed by fatty degeneration, in internal organs, capillary haemorrhages, &c. In septicaemia.
In another class of diseases, the organisms. first produce some well-marked local lesion, from which secondary extension takes place by the lymph or blood stream to other parts of the body, where corresponding lesions are formed.
In all such cases there is seen a selective character in the distribution of the lesions, some organs being in any disease much more liable to infection than others.
The lesions mentioned are in many instances necessarily accompanied by functional disturbances or clinical symptoms, symptoms. varying according to site, and to the nature and degree of the affection.
An illness with no serious effects on humans, cowpox caused lesions on cows' udders which then could spread to dairymaids' hands.